CC103_MOUSE
ID CC103_MOUSE Reviewed; 237 AA.
AC Q9D9P2; A2AH86;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Coiled-coil domain-containing protein 103;
GN Name=Ccdc103;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Dynein-attachment factor required for cilia motility.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, cilium,
CC flagellum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCDC103/PR46b family. {ECO:0000305}.
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DR EMBL; AK006639; BAB24684.1; -; mRNA.
DR EMBL; AK032002; BAC27644.1; -; mRNA.
DR EMBL; AL731670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119102; AAI19103.1; -; mRNA.
DR EMBL; BC119104; AAI19105.1; -; mRNA.
DR CCDS; CCDS25506.1; -.
DR RefSeq; NP_082768.1; NM_028492.2.
DR AlphaFoldDB; Q9D9P2; -.
DR SMR; Q9D9P2; -.
DR BioGRID; 215899; 1.
DR STRING; 10090.ENSMUSP00000021307; -.
DR PhosphoSitePlus; Q9D9P2; -.
DR PaxDb; Q9D9P2; -.
DR PRIDE; Q9D9P2; -.
DR ProteomicsDB; 281237; -.
DR Antibodypedia; 52477; 46 antibodies from 11 providers.
DR DNASU; 73293; -.
DR Ensembl; ENSMUST00000021307; ENSMUSP00000021307; ENSMUSG00000020930.
DR GeneID; 73293; -.
DR KEGG; mmu:73293; -.
DR UCSC; uc007lst.1; mouse.
DR CTD; 388389; -.
DR MGI; MGI:1920543; Ccdc103.
DR VEuPathDB; HostDB:ENSMUSG00000020930; -.
DR eggNOG; ENOG502RY3P; Eukaryota.
DR GeneTree; ENSGT00390000004038; -.
DR HOGENOM; CLU_085512_0_0_1; -.
DR InParanoid; Q9D9P2; -.
DR OMA; YRNWRRH; -.
DR OrthoDB; 1451158at2759; -.
DR PhylomeDB; Q9D9P2; -.
DR TreeFam; TF324467; -.
DR BioGRID-ORCS; 73293; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D9P2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D9P2; protein.
DR Bgee; ENSMUSG00000020930; Expressed in seminiferous tubule of testis and 74 other tissues.
DR ExpressionAtlas; Q9D9P2; baseline and differential.
DR Genevisible; Q9D9P2; MM.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0036157; C:outer dynein arm; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISO:MGI.
DR GO; GO:0003341; P:cilium movement; ISO:MGI.
DR GO; GO:0071907; P:determination of digestive tract left/right asymmetry; ISO:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IBA:GO_Central.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IBA:GO_Central.
DR GO; GO:0001947; P:heart looping; ISO:MGI.
DR GO; GO:0036159; P:inner dynein arm assembly; ISO:MGI.
DR GO; GO:0036158; P:outer dynein arm assembly; ISO:MGI.
DR InterPro; IPR042422; CC103.
DR InterPro; IPR031733; Dynein_attach_N.
DR InterPro; IPR025986; RPAP3-like_C.
DR PANTHER; PTHR28572; PTHR28572; 1.
DR Pfam; PF15867; Dynein_attach_N; 1.
DR Pfam; PF13877; RPAP3_C; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW Cytoplasm; Flagellum; Reference proteome.
FT CHAIN 1..237
FT /note="Coiled-coil domain-containing protein 103"
FT /id="PRO_0000263637"
FT COILED 8..33
FT /evidence="ECO:0000255"
SQ SEQUENCE 237 AA; 26861 MW; 47F6875205715931 CRC64;
MEKNDVINFK ALEKELQAAL AADEKYKREN AAKLRAVEQR VPSYEEFRGI VLASHLKPLE
QKDKMGGKRF VPWNCHTTRE RTSQDVVTEI PQEKSPFQPT TSAEFYRDWR RHLRSGPERY
QALLQLGGPK LGHLFQMDVG FGLLGELLVA LAEHARLSDR TAVLGILHSL ANTGRFNLNL
SLLSHAERES CQRLFQKLQA MSTTRPMQEG LTVEEPSAGL QGEEGLLQEL LELYGVH
