ID   YVRG_BACSU              Reviewed;         580 AA.
AC   O34989; Q7B2K3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Sensor histidine kinase YvrG;
DE            EC=2.7.13.3;
GN   Name=yvrG; OrderedLocusNames=BSU33210;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 394-395.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA   Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA   Fujita Y.;
RT   "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT   regulatory systems.";
RL   J. Bacteriol. 183:7365-7370(2001).
RN   [5]
RP   FUNCTION.
RX   PubMed=16306698; DOI=10.1271/bbb.69.2155;
RA   Serizawa M., Kodama K., Yamamoto H., Kobayashi K., Ogasawara N.,
RA   Sekiguchi J.;
RT   "Functional analysis of the YvrGHb two-component system of Bacillus
RT   subtilis: identification of the regulated genes by DNA microarray and
RT   northern blot analyses.";
RL   Biosci. Biotechnol. Biochem. 69:2155-2169(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system YvrG/YvrH that
CC       positively regulates 7 transcriptional units (wprA, wapA-yxxG,
CC       dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX-rsiX), and
CC       negatively regulates the lytABC operon. Probably activates YvrH by
CC       phosphorylation. {ECO:0000269|PubMed:11717295,
CC       ECO:0000269|PubMed:16306698}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA11731.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ223978; CAA11731.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB15311.2; -; Genomic_DNA.
DR   PIR; B70047; B70047.
DR   RefSeq; NP_391201.2; NC_000964.3.
DR   RefSeq; WP_003243980.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O34989; -.
DR   SMR; O34989; -.
DR   STRING; 224308.BSU33210; -.
DR   PaxDb; O34989; -.
DR   PRIDE; O34989; -.
DR   EnsemblBacteria; CAB15311; CAB15311; BSU_33210.
DR   GeneID; 935985; -.
DR   KEGG; bsu:BSU33210; -.
DR   PATRIC; fig|224308.179.peg.3602; -.
DR   eggNOG; COG2205; Bacteria.
DR   InParanoid; O34989; -.
DR   OMA; IIQFIMQ; -.
DR   PhylomeDB; O34989; -.
DR   BioCyc; BSUB:BSU33210-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009927; F:histidine phosphotransfer kinase activity; IBA:GO_Central.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IBA:GO_Central.
DR   GO; GO:0046777; P:protein autophosphorylation; IBA:GO_Central.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..580
FT                   /note="Sensor histidine kinase YvrG"
FT                   /id="PRO_0000360787"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..261
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..580
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          363..580
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         366
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   CONFLICT        394..395
FT                   /note="VK -> GE (in Ref. 1; CAA11731)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   580 AA;  67799 MW;  5FC6D889083EADC0 CRC64;
     MRLRWKFLFH FFGQMLIVIL LLTVMLVASF FYLDARFSDA ESNSGLTKAT TDTLEAYLDV
     NEDGTWEVDN FLKKSVDKQH GWMQIIDSEG NTDYSYGVPK DVPGTYTKKE LLSIYKTKKL
     HNYKLNYWAI NIEDKSYLLL SGWKSKSEQL LTSVEKREQK IDSLAHYKSS TIDYIKRKKG
     AIYLLDSNGK ILDSINSTKS ERKTMNQLEL LKYSSKPWNY KREISVKILN KDRWMVATVP
     NPVYVTDQEF NKSFLKVVLK AMFLVMAVLF MYIIWMTVWY MFRFGLPIFH TIRWLVNLSK
     GKLEEPRNRE GRPVSKNKKG KIKQPYRFFG EIFESMDQLT ETLRRDKRNR EKIQATREEW
     IAGLSHDLKT PLSSIYGYSM MLESKQYDWS PEEVKEMGQV VREKSEYMSK LIEDLNLTYR
     LKNDALPIER KLTSLIPFFK NVIEDFKKNP FSEGYDISFV SKEEHIEFAL DEAWFRRILE
     NLLGNAVKHN GKGTEIQVIL EQTKNHISLK VKDNGKGMDE ETITHLFNRY YRGTNTKDST
     AGTGLGLAIA KELVHLHNGT IHVNSRTNIG TVITILFKKQ