ID   YVRH_BACSU              Reviewed;         237 AA.
AC   P94504; Q7B2K4;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 4.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Transcriptional regulatory protein YvrH;
GN   Name=yvrH; Synonyms=yvrHb; OrderedLocusNames=BSU33220;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 208.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA   Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA   Fujita Y.;
RT   "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT   regulatory systems.";
RL   J. Bacteriol. 183:7365-7370(2001).
RN   [5]
RP   FUNCTION.
RX   PubMed=16306698; DOI=10.1271/bbb.69.2155;
RA   Serizawa M., Kodama K., Yamamoto H., Kobayashi K., Ogasawara N.,
RA   Sekiguchi J.;
RT   "Functional analysis of the YvrGHb two-component system of Bacillus
RT   subtilis: identification of the regulated genes by DNA microarray and
RT   northern blot analyses.";
RL   Biosci. Biotechnol. Biochem. 69:2155-2169(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system YvrG/YvrH that
CC       positively regulates 7 transcriptional units (wprA, wapA-yxxG,
CC       dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX-rsiX), and
CC       negatively regulates the lytABC operon. {ECO:0000269|PubMed:11717295,
CC       ECO:0000269|PubMed:16306698}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by YvrG. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA11730.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ223978; CAA11730.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB15312.2; -; Genomic_DNA.
DR   PIR; C70047; C70047.
DR   RefSeq; NP_391202.2; NC_000964.3.
DR   RefSeq; WP_003243545.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; P94504; -.
DR   SMR; P94504; -.
DR   STRING; 224308.BSU33221; -.
DR   PaxDb; P94504; -.
DR   PRIDE; P94504; -.
DR   EnsemblBacteria; CAB15312; CAB15312; BSU_33221.
DR   GeneID; 935974; -.
DR   KEGG; bsu:BSU33221; -.
DR   PATRIC; fig|224308.43.peg.3481; -.
DR   eggNOG; COG0745; Bacteria.
DR   InParanoid; P94504; -.
DR   OMA; GHVVECS; -.
DR   PhylomeDB; P94504; -.
DR   BioCyc; BSUB:BSU33221-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Repressor; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..237
FT                   /note="Transcriptional regulatory protein YvrH"
FT                   /id="PRO_0000360779"
FT   DOMAIN          5..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        131..230
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         55
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   CONFLICT        208
FT                   /note="I -> T (in Ref. 1; CAA11730)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   237 AA;  26679 MW;  3740B925A05F0C4B CRC64;
     MENASILIVD DEKAIVDMIK RVLEKEGYRN ILDAASAEEA IPVVKANKVD LIVLDVMMGG
     MSGFEACTLI REYSDAPIFF LTARSSDADK LSGFAVGADD YITKPFNPLE LAARIRAHLK
     RTYQSKETSS NQTYTYDYFT FSPQNAELIV GGEAVACSAQ LLQLLQYFCE HPNVVLSKDQ
     IYEKVWGYPS YGDNNTVMVH IRKLREKIER DPSNPEYIVT VRGLGYRFIP NPEGKRS