CC103_XENTR
ID CC103_XENTR Reviewed; 225 AA.
AC Q5RJU3; Q28IJ1;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Coiled-coil domain-containing protein 103;
GN Name=ccdc103; ORFNames=TNeu101c05.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Dynein-attachment factor required for cilia motility.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, cilium,
CC flagellum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCDC103/PR46b family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH86501.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR760363; CAJ82355.1; -; mRNA.
DR EMBL; AAMC01047356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC086501; AAH86501.1; ALT_INIT; mRNA.
DR EMBL; BC135828; AAI35829.1; -; mRNA.
DR RefSeq; NP_001034822.1; NM_001039733.1.
DR RefSeq; XP_012827165.1; XM_012971711.2.
DR AlphaFoldDB; Q5RJU3; -.
DR SMR; Q5RJU3; -.
DR PaxDb; Q5RJU3; -.
DR GeneID; 496703; -.
DR KEGG; xtr:496703; -.
DR CTD; 388389; -.
DR Xenbase; XB-GENE-922050; ccdc103.
DR eggNOG; ENOG502RY3P; Eukaryota.
DR HOGENOM; CLU_085512_0_0_1; -.
DR InParanoid; Q5RJU3; -.
DR OrthoDB; 1451158at2759; -.
DR TreeFam; TF324467; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0036157; C:outer dynein arm; IEA:InterPro.
DR GO; GO:0007368; P:determination of left/right symmetry; IBA:GO_Central.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IBA:GO_Central.
DR GO; GO:0036159; P:inner dynein arm assembly; IBA:GO_Central.
DR InterPro; IPR042422; CC103.
DR InterPro; IPR031733; Dynein_attach_N.
DR InterPro; IPR025986; RPAP3-like_C.
DR PANTHER; PTHR28572; PTHR28572; 1.
DR Pfam; PF15867; Dynein_attach_N; 1.
DR Pfam; PF13877; RPAP3_C; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW Cytoplasm; Flagellum; Reference proteome.
FT CHAIN 1..225
FT /note="Coiled-coil domain-containing protein 103"
FT /id="PRO_0000419463"
FT COILED 8..32
FT /evidence="ECO:0000255"
SQ SEQUENCE 225 AA; 25780 MW; 3EB79ADEEFBC91F2 CRC64;
MDDLETLDFR ELERELANAL AADQKYSREN DAKFRAIHQK VASYEEFRDI VLASNLKPLE
RKDKVGGESK QPWNPSFNTT NCTQKSEDVM LKKSLSDPTN AFEFARDWRR LGNVEKYDFL
LQLGAEKLSQ LFHAEVCSGL LGEFLLVLSE SFQAIHVEKV LKILQTLAET KRFDLNLIFI
SRSEVESSQK LFGKLQTCVG AMKDEKRGLG DENLRKLMAC YKISC