CC105_HUMAN
ID CC105_HUMAN Reviewed; 499 AA.
AC Q8IYK2; Q8N7T5; Q8NDL5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Coiled-coil domain-containing protein 105;
GN Name=CCDC105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-434 AND THR-444.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-499, AND VARIANT THR-444.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- INTERACTION:
CC Q8IYK2; P43364: MAGEA11; NbExp=3; IntAct=EBI-10818513, EBI-739552;
CC Q8IYK2; Q14696: MESD; NbExp=3; IntAct=EBI-10818513, EBI-6165891;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK097684; BAC05142.1; -; mRNA.
DR EMBL; AC004659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035678; AAH35678.1; -; mRNA.
DR EMBL; AL833847; CAD38706.1; -; mRNA.
DR CCDS; CCDS12322.1; -.
DR RefSeq; NP_775753.2; NM_173482.2.
DR AlphaFoldDB; Q8IYK2; -.
DR SMR; Q8IYK2; -.
DR BioGRID; 125989; 4.
DR IntAct; Q8IYK2; 3.
DR STRING; 9606.ENSP00000292574; -.
DR iPTMnet; Q8IYK2; -.
DR PhosphoSitePlus; Q8IYK2; -.
DR BioMuta; CCDC105; -.
DR DMDM; 296439422; -.
DR MassIVE; Q8IYK2; -.
DR PaxDb; Q8IYK2; -.
DR PeptideAtlas; Q8IYK2; -.
DR PRIDE; Q8IYK2; -.
DR ProteomicsDB; 71191; -.
DR Antibodypedia; 59288; 26 antibodies from 14 providers.
DR DNASU; 126402; -.
DR Ensembl; ENST00000292574.4; ENSP00000292574.2; ENSG00000160994.4.
DR GeneID; 126402; -.
DR KEGG; hsa:126402; -.
DR MANE-Select; ENST00000292574.4; ENSP00000292574.2; NM_173482.3; NP_775753.2.
DR UCSC; uc002nae.3; human.
DR CTD; 126402; -.
DR GeneCards; CCDC105; -.
DR HGNC; HGNC:26866; CCDC105.
DR HPA; ENSG00000160994; Tissue enriched (testis).
DR neXtProt; NX_Q8IYK2; -.
DR OpenTargets; ENSG00000160994; -.
DR PharmGKB; PA145008634; -.
DR VEuPathDB; HostDB:ENSG00000160994; -.
DR eggNOG; ENOG502RUEW; Eukaryota.
DR GeneTree; ENSGT00390000003207; -.
DR HOGENOM; CLU_052125_0_0_1; -.
DR InParanoid; Q8IYK2; -.
DR OMA; ECATALY; -.
DR OrthoDB; 1258302at2759; -.
DR PhylomeDB; Q8IYK2; -.
DR TreeFam; TF329813; -.
DR PathwayCommons; Q8IYK2; -.
DR SignaLink; Q8IYK2; -.
DR BioGRID-ORCS; 126402; 8 hits in 1064 CRISPR screens.
DR ChiTaRS; CCDC105; human.
DR GenomeRNAi; 126402; -.
DR Pharos; Q8IYK2; Tdark.
DR PRO; PR:Q8IYK2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IYK2; protein.
DR Bgee; ENSG00000160994; Expressed in left testis and 12 other tissues.
DR Genevisible; Q8IYK2; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR InterPro; IPR038949; CCDC105.
DR PANTHER; PTHR35081; PTHR35081; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..499
FT /note="Coiled-coil domain-containing protein 105"
FT /id="PRO_0000279391"
FT COILED 197..227
FT /evidence="ECO:0000255"
FT COILED 297..317
FT /evidence="ECO:0000255"
FT MOD_RES 372
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9D4K7"
FT VARIANT 245
FT /note="V -> M (in dbSNP:rs35352238)"
FT /id="VAR_056774"
FT VARIANT 248
FT /note="M -> T (in dbSNP:rs34375549)"
FT /id="VAR_056775"
FT VARIANT 434
FT /note="D -> E (in dbSNP:rs17855585)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030875"
FT VARIANT 444
FT /note="S -> T (in dbSNP:rs8111625)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_030876"
FT VARIANT 499
FT /note="P -> T (in dbSNP:rs8112667)"
FT /id="VAR_030877"
SQ SEQUENCE 499 AA; 56909 MW; 4B8CE8E0FBCE65B0 CRC64;
MRVLVPPAER SQDTRVGAPA WREAAQAMAR TAHILTDRCG QEAVTMWQPK DSVLDPNVAH
HLGRAAYIQP WRFRVEMIKG GGTLEKPPPG EGVTLWKGKM KPPAWYARLP LPLHRKARAL
QTTEVVHAHA RGARLTAARL GRAQHQINGR VRQLLRQREV TDHRLSEVRK GLLINQQSVK
LRGYRPKSEK VPDKADSMLT WEKEELKSMK RKMERDMEKS EVLLKTLASC RDTLNFCFKE
RLQAVDLMNQ PLDKVLEQAR RHSWVNLSRA PTPRTQGQKT PPPDPVGTYN PACALALNEA
KRLLVESKDT LVEMAKNEVD VREQQLQISD RVCASLAQKA SETLELKERL NMTLGLMRGT
ILRCTKYNQE LYTTHGLIKG PLSKVHLETA EKLDRPLVRM YQRHVGTQLP EAARLAQGTD
KLQCHITYLE KNLDELLATH KNLSWGLNCK NIGHEVDGNV VRLRLRQRQP HVCYEQAQRL
VKDWDPRTPP PRSKSSADP
