CC105_MOUSE
ID CC105_MOUSE Reviewed; 499 AA.
AC Q9D4K7; G3X9S0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Coiled-coil domain-containing protein 105;
GN Name=Ccdc105;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-429.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-372, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB30245.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC159747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466553; EDL31718.1; -; Genomic_DNA.
DR EMBL; AK016452; BAB30245.1; ALT_FRAME; mRNA.
DR CCDS; CCDS48614.1; -.
DR RefSeq; NP_081906.1; NM_027630.1.
DR AlphaFoldDB; Q9D4K7; -.
DR SMR; Q9D4K7; -.
DR STRING; 10090.ENSMUSP00000101022; -.
DR iPTMnet; Q9D4K7; -.
DR PhosphoSitePlus; Q9D4K7; -.
DR PaxDb; Q9D4K7; -.
DR PRIDE; Q9D4K7; -.
DR ProteomicsDB; 281479; -.
DR Antibodypedia; 59288; 26 antibodies from 14 providers.
DR Ensembl; ENSMUST00000105383; ENSMUSP00000101022; ENSMUSG00000078442.
DR GeneID; 70976; -.
DR KEGG; mmu:70976; -.
DR UCSC; uc007fyf.2; mouse.
DR CTD; 126402; -.
DR MGI; MGI:1918226; Ccdc105.
DR VEuPathDB; HostDB:ENSMUSG00000078442; -.
DR eggNOG; ENOG502RUEW; Eukaryota.
DR GeneTree; ENSGT00390000003207; -.
DR HOGENOM; CLU_052125_0_0_1; -.
DR InParanoid; Q9D4K7; -.
DR OMA; ECATALY; -.
DR OrthoDB; 1258302at2759; -.
DR PhylomeDB; Q9D4K7; -.
DR TreeFam; TF329813; -.
DR BioGRID-ORCS; 70976; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc105; mouse.
DR PRO; PR:Q9D4K7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9D4K7; protein.
DR Bgee; ENSMUSG00000078442; Expressed in seminiferous tubule of testis and 17 other tissues.
DR Genevisible; Q9D4K7; MM.
DR InterPro; IPR038949; CCDC105.
DR PANTHER; PTHR35081; PTHR35081; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..499
FT /note="Coiled-coil domain-containing protein 105"
FT /id="PRO_0000279392"
FT REGION 265..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..225
FT /evidence="ECO:0000255"
FT COILED 308..328
FT /evidence="ECO:0000255"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V7B5"
FT MOD_RES 372
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 118
FT /note="R -> C (in Ref. 3; BAB30245)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="V -> A (in Ref. 3; BAB30245)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="D -> H (in Ref. 3; BAB30245)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 499 AA; 57304 MW; 7C07F09750A4CBBE CRC64;
MPVLLPSTDP GQDSRVGAPE WRQAAKATSR KAHLLTDRCG QEAVTMWQPK DSVLDPNVAH
HLGRAAYMEP WRFRVEMLKG GGTLEKPPPG EGVTLWKGKM KPPAWYARLP LPMHRDARAQ
QTAEVVHAHA RGARLTAARL GRAQHQINGQ LRLLLRQREA TDRRLSEVRK GLLINQQSVK
LRGYRPKCEK IPDKADSLLV WEKKELKSMK RKMEKDMEIS EDLLKALASC RDTLDFYCQE
RLQAVELMNQ PLDKVLEQAG RHSWVDITRP PTPRTQGLKT PPPDPIGTYT PACAKALFEA
KRLLMESKDI LTEMAKNEVD IQNQQQEISN RVCSSLAQKM RETLELKERM TMTLGLMRGT
IHRCMKFNQE MYVTRGIIKG PLLKRNLEAR EKLNRPLVRM YQRHVGTQLP EATRLAQGTD
LLTRHNLHME KNLKELRTTH DNLAWGLNCK KIGHDVDYDV VRLRLRQRHP HVCYEQAQRL
VNDWDPPTPA RSQTNTASK
