YWCE_BACSU
ID YWCE_BACSU Reviewed; 87 AA.
AC P39603;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Spore morphogenesis and germination protein YwcE;
GN Name=ywcE; OrderedLocusNames=BSU38130; ORFNames=ipa-41r;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7934828; DOI=10.1111/j.1365-2958.1993.tb01963.x;
RA Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F.,
RA Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E.,
RA Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A.;
RT "Bacillus subtilis genome project: cloning and sequencing of the 97 kb
RT region from 325 degrees to 333 degrees.";
RL Mol. Microbiol. 10:371-384(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16159778; DOI=10.1128/jb.187.18.6443-6453.2005;
RA Real G., Pinto S.M., Schyns G., Costa T., Henriques A.O., Moran C.P. Jr.;
RT "A gene encoding a holin-like protein involved in spore morphogenesis and
RT spore germination in Bacillus subtilis.";
RL J. Bacteriol. 187:6443-6453(2005).
CC -!- FUNCTION: Required for proper spore morphogenesis. Important for spore
CC germination. {ECO:0000269|PubMed:16159778}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16159778}.
CC Spore membrane {ECO:0000269|PubMed:16159778}; Multi-pass membrane
CC protein {ECO:0000269|PubMed:16159778}. Spore outer membrane
CC {ECO:0000269|PubMed:16159778}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16159778}. Note=Inner and outer prespore membrane.
CC Mother cell membrane.
CC -!- DEVELOPMENTAL STAGE: Expressed at the onset of sporulation.
CC -!- INDUCTION: Repressed by AbrB during growth and activated at the onset
CC of sporulation in a Spo0A-dependent manner.
CC -!- SIMILARITY: Belongs to the YwcE family. {ECO:0000305}.
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DR EMBL; X73124; CAA51597.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15839.1; -; Genomic_DNA.
DR PIR; S39696; S39696.
DR RefSeq; NP_391692.1; NC_000964.3.
DR RefSeq; WP_003227411.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P39603; -.
DR STRING; 224308.BSU38130; -.
DR TCDB; 1.E.23.1.1; the bacillus spore morphogenesis and germination holin (bsh) family.
DR PaxDb; P39603; -.
DR EnsemblBacteria; CAB15839; CAB15839; BSU_38130.
DR GeneID; 64305587; -.
DR GeneID; 937296; -.
DR KEGG; bsu:BSU38130; -.
DR PATRIC; fig|224308.43.peg.3997; -.
DR eggNOG; ENOG5033HBX; Bacteria.
DR OMA; LWLEHRK; -.
DR BioCyc; BSUB:BSU38130-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043594; C:outer endospore membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009847; P:spore germination; IMP:CACAO.
DR InterPro; IPR020185; Spore_morphogenesis_YwcE.
DR Pfam; PF17368; YwcE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Germination; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..87
FT /note="Spore morphogenesis and germination protein YwcE"
FT /id="PRO_0000049960"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 87 AA; 9959 MW; CC74135F423940CB CRC64;
MMDMFFAYLL VASATPLFIW LDNKKVALSA IPPIILMWVF FFFYATESLS PLGHTLMIIL
FAVNVIVAHI AAFIIYGLPY LRRKRSS
