CC106_BOVIN
ID CC106_BOVIN Reviewed; 278 AA.
AC Q1LZ89;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Coiled-coil domain-containing protein 106;
GN Name=CCDC106;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its
CC transactivity. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with p53/TP53. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with
CC p53/TP53. {ECO:0000250}.
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DR EMBL; BC116140; AAI16141.1; -; mRNA.
DR RefSeq; NP_001073803.1; NM_001080334.1.
DR RefSeq; XP_010813795.1; XM_010815493.2.
DR RefSeq; XP_015313871.1; XM_015458385.1.
DR AlphaFoldDB; Q1LZ89; -.
DR SMR; Q1LZ89; -.
DR STRING; 9913.ENSBTAP00000015303; -.
DR PaxDb; Q1LZ89; -.
DR PRIDE; Q1LZ89; -.
DR Ensembl; ENSBTAT00000015303; ENSBTAP00000015303; ENSBTAG00000011517.
DR GeneID; 618485; -.
DR KEGG; bta:618485; -.
DR CTD; 29903; -.
DR VEuPathDB; HostDB:ENSBTAG00000011517; -.
DR VGNC; VGNC:26831; CCDC106.
DR eggNOG; ENOG502RTFM; Eukaryota.
DR GeneTree; ENSGT00390000013183; -.
DR HOGENOM; CLU_069155_0_0_1; -.
DR InParanoid; Q1LZ89; -.
DR OMA; VMSDTIN; -.
DR OrthoDB; 827808at2759; -.
DR TreeFam; TF331729; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000011517; Expressed in floor plate of diencephalon and 106 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR InterPro; IPR031591; CCDC106.
DR PANTHER; PTHR16477; PTHR16477; 1.
DR Pfam; PF15794; CCDC106; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..278
FT /note="Coiled-coil domain-containing protein 106"
FT /id="PRO_0000274342"
FT REGION 102..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..99
FT /evidence="ECO:0000255"
FT MOTIF 151..164
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 102..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BWC9"
SQ SEQUENCE 278 AA; 31387 MW; 6C441F0F51F7B100 CRC64;
MNSRRRPVKK DSEALEISIP FDETPHLDPQ IFYSLSPSRG NFEEPSEAAS PTAALMNGVR
AQLHLALERN SWLQKRIEDL EEERDFLRCQ LDKFISSARL DADDHCRGKP GPRRAEGDGR
GGTGGEASDP ESAASSLSGA SEEGSTVERK RQKQKGGPGR RRFGKPKARE RQRVKDADGV
LCRYKKILGT FQKLKSMSRA FEHHRVDRNT VALTTPIAEL LIVAPEKLAE VGEFDPSKER
LLEYSRRCFL ALDEETLKKV QALKKSKLLL PITYRFKR