CC106_HUMAN
ID CC106_HUMAN Reviewed; 280 AA.
AC Q9BWC9; B3KUF9; D3K183; Q99786;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Coiled-coil domain-containing protein 106;
GN Name=CCDC106;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
RP WITH TP53.
RX PubMed=20159018; DOI=10.1016/j.febslet.2010.02.031;
RA Zhou J., Qiao X., Xiao L., Sun W., Wang L., Li H., Wu Y., Ding X., Hu X.,
RA Zhou C., Zhang J.;
RT "Identification and characterization of the novel protein CCDC106 that
RT interacts with p53 and promotes its degradation.";
RL FEBS Lett. 584:1085-1090(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9110174; DOI=10.1101/gr.7.4.353;
RA Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT "Large-scale concatenation cDNA sequencing.";
RL Genome Res. 7:353-358(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-153.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its
CC transactivity. {ECO:0000269|PubMed:20159018}.
CC -!- SUBUNIT: Interacts with p53/TP53. {ECO:0000269|PubMed:20159018}.
CC -!- INTERACTION:
CC Q9BWC9; P18848: ATF4; NbExp=14; IntAct=EBI-711501, EBI-492498;
CC Q9BWC9; Q13698: CACNA1S; NbExp=3; IntAct=EBI-711501, EBI-5329490;
CC Q9BWC9; Q96LK0: CEP19; NbExp=3; IntAct=EBI-711501, EBI-741885;
CC Q9BWC9; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-711501, EBI-750700;
CC Q9BWC9; Q8IZU0: FAM9B; NbExp=8; IntAct=EBI-711501, EBI-10175124;
CC Q9BWC9; Q8WVZ9: KBTBD7; NbExp=3; IntAct=EBI-711501, EBI-473695;
CC Q9BWC9; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-711501, EBI-739909;
CC Q9BWC9; P43364: MAGEA11; NbExp=3; IntAct=EBI-711501, EBI-739552;
CC Q9BWC9; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-711501, EBI-746778;
CC Q9BWC9; P41227: NAA10; NbExp=3; IntAct=EBI-711501, EBI-747693;
CC Q9BWC9; Q6ZUT1: NKAPD1; NbExp=5; IntAct=EBI-711501, EBI-3920396;
CC Q9BWC9; P61970: NUTF2; NbExp=3; IntAct=EBI-711501, EBI-591778;
CC Q9BWC9; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-711501, EBI-1567797;
CC Q9BWC9; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-711501, EBI-1504830;
CC Q9BWC9; O00560: SDCBP; NbExp=3; IntAct=EBI-711501, EBI-727004;
CC Q9BWC9; P04637: TP53; NbExp=3; IntAct=EBI-711501, EBI-366083;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20159018}.
CC Note=Colocalizes with p53/TP53.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB50227.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU354321; ADC34060.1; -; mRNA.
DR EMBL; GU354322; ADC34061.1; -; mRNA.
DR EMBL; GU354323; ADC34062.1; -; mRNA.
DR EMBL; U79303; AAB50227.1; ALT_SEQ; mRNA.
DR EMBL; AK097095; BAG53421.1; -; mRNA.
DR EMBL; BC000412; AAH00412.1; -; mRNA.
DR EMBL; BC008956; AAH08956.1; -; mRNA.
DR EMBL; CR450308; CAG29304.1; -; mRNA.
DR CCDS; CCDS33118.1; -.
DR RefSeq; NP_037433.2; NM_013301.2.
DR RefSeq; XP_005258884.1; XM_005258827.2.
DR RefSeq; XP_005258885.1; XM_005258828.2.
DR AlphaFoldDB; Q9BWC9; -.
DR SMR; Q9BWC9; -.
DR BioGRID; 118952; 55.
DR IntAct; Q9BWC9; 36.
DR MINT; Q9BWC9; -.
DR STRING; 9606.ENSP00000465757; -.
DR iPTMnet; Q9BWC9; -.
DR PhosphoSitePlus; Q9BWC9; -.
DR BioMuta; CCDC106; -.
DR DMDM; 74733424; -.
DR jPOST; Q9BWC9; -.
DR MassIVE; Q9BWC9; -.
DR MaxQB; Q9BWC9; -.
DR PaxDb; Q9BWC9; -.
DR PeptideAtlas; Q9BWC9; -.
DR PRIDE; Q9BWC9; -.
DR ProteomicsDB; 79267; -.
DR Antibodypedia; 33135; 203 antibodies from 27 providers.
DR DNASU; 29903; -.
DR Ensembl; ENST00000308964.7; ENSP00000309681.2; ENSG00000173581.8.
DR Ensembl; ENST00000586790.6; ENSP00000465757.1; ENSG00000173581.8.
DR Ensembl; ENST00000588740.5; ENSP00000468539.1; ENSG00000173581.8.
DR Ensembl; ENST00000591578.5; ENSP00000466870.1; ENSG00000173581.8.
DR GeneID; 29903; -.
DR KEGG; hsa:29903; -.
DR MANE-Select; ENST00000586790.6; ENSP00000465757.1; NM_001370470.1; NP_001357399.1.
DR UCSC; uc002qlr.4; human.
DR CTD; 29903; -.
DR DisGeNET; 29903; -.
DR GeneCards; CCDC106; -.
DR HGNC; HGNC:30181; CCDC106.
DR HPA; ENSG00000173581; Low tissue specificity.
DR MIM; 613478; gene.
DR neXtProt; NX_Q9BWC9; -.
DR OpenTargets; ENSG00000173581; -.
DR PharmGKB; PA145008652; -.
DR VEuPathDB; HostDB:ENSG00000173581; -.
DR eggNOG; ENOG502RTFM; Eukaryota.
DR GeneTree; ENSGT00390000013183; -.
DR InParanoid; Q9BWC9; -.
DR OMA; VMSDTIN; -.
DR OrthoDB; 827808at2759; -.
DR PhylomeDB; Q9BWC9; -.
DR TreeFam; TF331729; -.
DR PathwayCommons; Q9BWC9; -.
DR SignaLink; Q9BWC9; -.
DR BioGRID-ORCS; 29903; 52 hits in 1083 CRISPR screens.
DR ChiTaRS; CCDC106; human.
DR GenomeRNAi; 29903; -.
DR Pharos; Q9BWC9; Tdark.
DR PRO; PR:Q9BWC9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BWC9; protein.
DR Bgee; ENSG00000173581; Expressed in nucleus accumbens and 123 other tissues.
DR ExpressionAtlas; Q9BWC9; baseline and differential.
DR Genevisible; Q9BWC9; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR031591; CCDC106.
DR PANTHER; PTHR16477; PTHR16477; 1.
DR Pfam; PF15794; CCDC106; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..280
FT /note="Coiled-coil domain-containing protein 106"
FT /id="PRO_0000274343"
FT REGION 103..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 63..101
FT /evidence="ECO:0000255"
FT MOTIF 151..164
FT /note="Bipartite nuclear localization signal"
FT COMPBIAS 103..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..170
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 280 AA; 32032 MW; 8A380144441AEA33 CRC64;
MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA ASSALALMNS
VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA RMEAEDHCRM KPGPRRMEGD
SRGGAGGEAS DPESAASSLS GASEEGSASE RRRQKQKGGA SRRRFGKPKA RERQRVKDAD
GVLCRYKKIL GTFQKLKSMS RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK
ERLLEYSRRC FLALDDETLK KVQALKKSKL LLPITYRFKR
