CC106_MOUSE
ID CC106_MOUSE Reviewed; 279 AA.
AC Q3ULM0; Q8K5E2; Q8VEI0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Coiled-coil domain-containing protein 106;
GN Name=Ccdc106; ORFNames=MNCb-2071;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 79-86, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its
CC transactivity. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with p53/TP53. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with
CC p53/TP53. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3ULM0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3ULM0-2; Sequence=VSP_022717, VSP_022718;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB041804; BAB93550.1; -; mRNA.
DR EMBL; AK145417; BAE26428.1; -; mRNA.
DR EMBL; BC018462; AAH18462.1; -; mRNA.
DR CCDS; CCDS20757.1; -. [Q3ULM0-1]
DR RefSeq; NP_001277358.1; NM_001290429.1.
DR RefSeq; NP_001277361.1; NM_001290432.1. [Q3ULM0-1]
DR RefSeq; NP_666290.2; NM_146178.2. [Q3ULM0-1]
DR RefSeq; XP_006539847.1; XM_006539784.3. [Q3ULM0-1]
DR RefSeq; XP_006539848.1; XM_006539785.3. [Q3ULM0-1]
DR RefSeq; XP_006539849.1; XM_006539786.3. [Q3ULM0-1]
DR RefSeq; XP_006539851.1; XM_006539788.3. [Q3ULM0-1]
DR AlphaFoldDB; Q3ULM0; -.
DR STRING; 10090.ENSMUSP00000041033; -.
DR iPTMnet; Q3ULM0; -.
DR PhosphoSitePlus; Q3ULM0; -.
DR PaxDb; Q3ULM0; -.
DR PRIDE; Q3ULM0; -.
DR ProteomicsDB; 281480; -. [Q3ULM0-1]
DR ProteomicsDB; 281481; -. [Q3ULM0-2]
DR Antibodypedia; 33135; 203 antibodies from 27 providers.
DR DNASU; 232821; -.
DR Ensembl; ENSMUST00000045543; ENSMUSP00000041033; ENSMUSG00000035228. [Q3ULM0-1]
DR Ensembl; ENSMUST00000207974; ENSMUSP00000146775; ENSMUSG00000035228. [Q3ULM0-2]
DR GeneID; 232821; -.
DR KEGG; mmu:232821; -.
DR UCSC; uc009ezr.3; mouse. [Q3ULM0-2]
DR UCSC; uc009ezs.2; mouse. [Q3ULM0-1]
DR CTD; 29903; -.
DR MGI; MGI:2385900; Ccdc106.
DR VEuPathDB; HostDB:ENSMUSG00000035228; -.
DR eggNOG; ENOG502RTFM; Eukaryota.
DR GeneTree; ENSGT00390000013183; -.
DR HOGENOM; CLU_069155_0_0_1; -.
DR InParanoid; Q3ULM0; -.
DR OrthoDB; 827808at2759; -.
DR PhylomeDB; Q3ULM0; -.
DR TreeFam; TF331729; -.
DR BioGRID-ORCS; 232821; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ccdc106; mouse.
DR PRO; PR:Q3ULM0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3ULM0; protein.
DR Bgee; ENSMUSG00000035228; Expressed in embryonic brain and 145 other tissues.
DR ExpressionAtlas; Q3ULM0; baseline and differential.
DR Genevisible; Q3ULM0; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR031591; CCDC106.
DR PANTHER; PTHR16477; PTHR16477; 1.
DR Pfam; PF15794; CCDC106; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Direct protein sequencing; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..279
FT /note="Coiled-coil domain-containing protein 106"
FT /id="PRO_0000274344"
FT REGION 109..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..101
FT /evidence="ECO:0000255"
FT MOTIF 151..164
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 109..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..169
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BWC9"
FT VAR_SEQ 175..202
FT /note="VKDADGVLCRYKKILGTFQKLKSMSRAF -> GEWGVGTCDGCVEGLCTQNR
FT SVSSTVMP (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_022717"
FT VAR_SEQ 203..279
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_022718"
FT CONFLICT 6
FT /note="N -> S (in Ref. 1; BAB93550)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="S -> G (in Ref. 3; AAH18462)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 279 AA; 32098 MW; 1ABDEB45DAA61A0E CRC64;
MNDRNNRWRT MKDEETFEIS IPFEEAPHLD SQILYRLSPS RRNVEEPPEG ASPTLALMSS
VKAQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA RMDAEDYCRM KPGPRRVDGD
SRAGVGEASD PESAASSFSG VSEDGSASER KRQKQKGSTS RKRFGKTKAR ERQRVKDADG
VLCRYKKILG TFQKLKSMSR AFEHHRVDRN TVALTTPIAE LLIVAPEKLA EVGEFDPSKE
RLLEYSRRCF LALDDETLKK VQALKKSKLL LPITYRFKR
