CC107_MOUSE
ID CC107_MOUSE Reviewed; 242 AA.
AC Q9DCC3; A2AIN4; Q9CTB6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Coiled-coil domain-containing protein 107;
DE Flags: Precursor;
GN Name=Ccdc107;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DCC3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DCC3-2; Sequence=VSP_024134;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB23140.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK002915; BAB22454.1; -; mRNA.
DR EMBL; AK004044; BAB23140.1; ALT_FRAME; mRNA.
DR EMBL; AL732506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027414; AAH27414.1; -; mRNA.
DR CCDS; CCDS18097.1; -. [Q9DCC3-1]
DR RefSeq; NP_001033002.1; NM_001037913.2. [Q9DCC3-1]
DR RefSeq; XP_006538201.1; XM_006538138.2. [Q9DCC3-2]
DR AlphaFoldDB; Q9DCC3; -.
DR SMR; Q9DCC3; -.
DR STRING; 10090.ENSMUSP00000030181; -.
DR iPTMnet; Q9DCC3; -.
DR PhosphoSitePlus; Q9DCC3; -.
DR PaxDb; Q9DCC3; -.
DR PRIDE; Q9DCC3; -.
DR ProteomicsDB; 281482; -. [Q9DCC3-1]
DR ProteomicsDB; 281483; -. [Q9DCC3-2]
DR Antibodypedia; 51334; 59 antibodies from 14 providers.
DR Ensembl; ENSMUST00000030181; ENSMUSP00000030181; ENSMUSG00000028461. [Q9DCC3-1]
DR Ensembl; ENSMUST00000107922; ENSMUSP00000103555; ENSMUSG00000028461. [Q9DCC3-2]
DR GeneID; 622404; -.
DR KEGG; mmu:622404; -.
DR UCSC; uc008spy.2; mouse. [Q9DCC3-1]
DR CTD; 203260; -.
DR MGI; MGI:1913423; Ccdc107.
DR VEuPathDB; HostDB:ENSMUSG00000028461; -.
DR eggNOG; ENOG502QQ24; Eukaryota.
DR GeneTree; ENSGT00390000018608; -.
DR HOGENOM; CLU_097023_0_0_1; -.
DR InParanoid; Q9DCC3; -.
DR OMA; ATSWQVE; -.
DR OrthoDB; 1332244at2759; -.
DR PhylomeDB; Q9DCC3; -.
DR TreeFam; TF333319; -.
DR BioGRID-ORCS; 622404; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc107; mouse.
DR PRO; PR:Q9DCC3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9DCC3; protein.
DR Bgee; ENSMUSG00000028461; Expressed in right kidney and 249 other tissues.
DR Genevisible; Q9DCC3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR038779; CCDC107.
DR PANTHER; PTHR37345; PTHR37345; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..242
FT /note="Coiled-coil domain-containing protein 107"
FT /id="PRO_0000282408"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 27..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..132
FT /evidence="ECO:0000255"
FT COMPBIAS 195..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 174
FT /note="P -> PGKRLGGFYGWRAMAVKLEQVGLSFT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_024134"
SQ SEQUENCE 242 AA; 26579 MW; C5C003A9EF9004D3 CRC64;
MEGAGPVLSI LGLLLVSAPF GVLGERPSAD LGAHPERGSQ VSPGTTEPRR QPPPKDQRER
ARAGSLSLGA LYTAAVVAFV LFKCLQGPDE AAVLREEKNK KKSSQSEQQL VQLTQQLAQT
EQHLNHLMTQ LDPLFEQVTT LVGTQRELLD TKLKTIHHLL QDCQPGTGVE VPEPEASIPF
TEDLGKEDQE AGNSQAWEEP ITWSPETRNL APSWEVEQGL RRRWHKTVTK GPAVNGEQPL
KV
