ID   YWQC_BACSU              Reviewed;         248 AA.
AC   P96715;
DT   01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Probable capsular polysaccharide biosynthesis protein YwqC;
GN   Name=ywqC; OrderedLocusNames=BSU36260;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA   Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA   Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA   Kunst F., Danchin A., Glaser P.;
RT   "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT   degrees).";
RL   Microbiology 143:3313-3328(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RX   PubMed=12970183; DOI=10.1093/emboj/cdg458;
RA   Mijakovic I., Poncet S., Boel G., Maze A., Gillet S., Jamet E.,
RA   Decottignies P., Grangeasse C., Doublet P., Le Marechal P., Deutscher J.;
RT   "Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-
RT   glucose dehydrogenases.";
RL   EMBO J. 22:4709-4718(2003).
CC   -!- FUNCTION: Required for YwqD kinase activity. May bring YwqD and its
CC       substrates into contact. Probably involved in the regulation of
CC       capsular polysaccharide biosynthesis. {ECO:0000269|PubMed:12970183}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- INTERACTION:
CC       P96715; P16971: recA; NbExp=3; IntAct=EBI-9302918, EBI-1535844;
CC       P96715; P71051: yveL; NbExp=4; IntAct=EBI-9302918, EBI-9303142;
CC       P96715; P96716: ywqD; NbExp=6; IntAct=EBI-9302918, EBI-9302929;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Not phosphorylated in vitro by YwqD.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; Z92952; CAB07455.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15643.1; -; Genomic_DNA.
DR   PIR; F70066; F70066.
DR   RefSeq; NP_391507.1; NC_000964.3.
DR   RefSeq; WP_003227811.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P96715; -.
DR   IntAct; P96715; 15.
DR   STRING; 224308.BSU36260; -.
DR   PaxDb; P96715; -.
DR   PRIDE; P96715; -.
DR   EnsemblBacteria; CAB15643; CAB15643; BSU_36260.
DR   GeneID; 936897; -.
DR   KEGG; bsu:BSU36260; -.
DR   PATRIC; fig|224308.179.peg.3924; -.
DR   eggNOG; COG3944; Bacteria.
DR   InParanoid; P96715; -.
DR   OMA; KICEVFV; -.
DR   PhylomeDB; P96715; -.
DR   BioCyc; BSUB:BSU36260-MON; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR032807; GNVR.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF13807; GNVR; 1.
DR   Pfam; PF02706; Wzz; 1.
PE   1: Evidence at protein level;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..248
FT                   /note="Probable capsular polysaccharide biosynthesis
FT                   protein YwqC"
FT                   /id="PRO_0000217233"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  26640 MW;  95DF89C01682FBED CRC64;
     MGESTSLKEI LSTLTKRILL IMIVTAAATA AGGLISFFAL TPIYENSTQI LVNQSKNERK
     EVQFNDVQTN LQLINTYNVI IKSPAILDEV IKEMGLSMTS QELNDKITVS SEQDSQVVNI
     SVRDENAETA AHIANTIASV FQDKITSIMN VDNVSILSKA EVSEHPSPVS PKPLLNIAIA
     FAAGLAGSIG LAFLLEHLDN TIKSEEQLES LLDIPVLGTV STIANEQKTA KTLQGFQSEK
     TGSGHFGA