CC110_MOUSE
ID CC110_MOUSE Reviewed; 848 AA.
AC Q3V125; Q3TTQ8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Coiled-coil domain-containing protein 110;
GN Name=Ccdc110; Synonyms=Gm172;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-620, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK132742; BAE21328.1; -; mRNA.
DR EMBL; AK161248; BAE36267.1; -; mRNA.
DR CCDS; CCDS22282.1; -.
DR RefSeq; NP_001028418.1; NM_001033246.2.
DR AlphaFoldDB; Q3V125; -.
DR SMR; Q3V125; -.
DR BioGRID; 229317; 1.
DR IntAct; Q3V125; 1.
DR STRING; 10090.ENSMUSP00000092964; -.
DR iPTMnet; Q3V125; -.
DR PhosphoSitePlus; Q3V125; -.
DR PaxDb; Q3V125; -.
DR PRIDE; Q3V125; -.
DR ProteomicsDB; 281238; -.
DR Ensembl; ENSMUST00000095326; ENSMUSP00000092964; ENSMUSG00000071104.
DR GeneID; 212392; -.
DR KEGG; mmu:212392; -.
DR UCSC; uc009lpm.1; mouse.
DR CTD; 256309; -.
DR MGI; MGI:2685018; Ccdc110.
DR VEuPathDB; HostDB:ENSMUSG00000071104; -.
DR eggNOG; ENOG502QR3F; Eukaryota.
DR GeneTree; ENSGT01050000245328; -.
DR HOGENOM; CLU_018125_0_0_1; -.
DR InParanoid; Q3V125; -.
DR OMA; CQIHFKD; -.
DR OrthoDB; 972885at2759; -.
DR PhylomeDB; Q3V125; -.
DR TreeFam; TF335739; -.
DR BioGRID-ORCS; 212392; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q3V125; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3V125; protein.
DR Bgee; ENSMUSG00000071104; Expressed in seminiferous tubule of testis and 19 other tissues.
DR ExpressionAtlas; Q3V125; baseline and differential.
DR Genevisible; Q3V125; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..848
FT /note="Coiled-coil domain-containing protein 110"
FT /id="PRO_0000249078"
FT REGION 41..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 442..794
FT /evidence="ECO:0000255"
FT MOD_RES 620
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 115
FT /note="N -> D (in Ref. 1; BAE36267)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 848 AA; 96356 MW; 38AA522471C17A14 CRC64;
MSPGYLPAPK AVLGSVPEKH LAEEDEVDSI LLSASKILNS SEGVKESGGN EPEYGCASEP
ENQIQPQSAL KVLQHQLESF QALRMQTLQN VSMVQSEISE ILNKSIVEVE TPQFNSEKSL
VFSMHPEKDL PNETQEEIPS TKTLHSMGET FSSNSDTGLP QGTDIPPQIQ VKDMLALQGL
RTTADNSPPK KAMNTSEQPS ATKSFSLYQF LPQGPQTAVP QAAPVILDKS TITTPFPKHG
FCANLDDICH SIKHMKEELQ KSHDKELALT SELHTFQADA STQGHHKHEP FPMHSSKLNF
IQQENMEGNL SEDMKSKRIS ELEALVSKLL PLRDTVSKLH VNFCRKCKKL SKSEVYRGKK
NEKNKDIPIT SKNIMDLKFH SRAPRYTLSV LDLGKHKIKD KEGQAFIVSQ GPATLENEKL
PKGKFIPEQC VPKQSVAKIH YLQNYLKESL QNQKKMTELE NENLALKTKM KPLVFTAQSL
IQKVEAHEKQ LKSLAEEKSA LQSKLSKAEE ENKDCLRELK KIVSTYNVLG GQHKMLEEKN
SQLSLEKQQM LETIDHLKSK EHKSQSDMAV LQNENSRMNI EIEAMKTSML LVQDEREMLE
KETYQLLKDK STLESDLKES KLEILQLKEK ERLIKAEQES LLHSLDTAKA EKLSLEATLQ
ESTSTRQKLE RKLVDIQAYQ SAAEEKFLKE IKSAKSETSI YKNNLAEISK ECEILSKMVM
EIKADNQILK EELKKHSQEN TKFENSISRL TEDKILLENY VRSIENEKDT LEFEMRNLQR
DYLSLSDKVS SQNNSASKST YISRREKLYF DNYDAYEDAS SLRNRPVASD LKGIPHKLYQ
RLPSKICK
