YWY3_CAEEL
ID YWY3_CAEEL Reviewed; 407 AA.
AC Q11090; Q8MQF5; Q8MQF6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative serine/threonine-protein kinase C01C4.3;
DE EC=2.7.11.1;
GN ORFNames=C01C4.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=Q11090-2; Sequence=Displayed;
CC Name=a;
CC IsoId=Q11090-1; Sequence=VSP_009624, VSP_009625;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; FO080252; CCD62364.1; -; Genomic_DNA.
DR EMBL; FO080252; CCD62365.1; -; Genomic_DNA.
DR PIR; T34074; T34074.
DR RefSeq; NP_741754.2; NM_171655.4.
DR RefSeq; NP_741755.1; NM_171656.1.
DR AlphaFoldDB; Q11090; -.
DR SMR; Q11090; -.
DR STRING; 6239.C01C4.3b; -.
DR iPTMnet; Q11090; -.
DR EPD; Q11090; -.
DR PaxDb; Q11090; -.
DR PeptideAtlas; Q11090; -.
DR EnsemblMetazoa; C01C4.3a.1; C01C4.3a.1; WBGene00015293. [Q11090-1]
DR EnsemblMetazoa; C01C4.3a.2; C01C4.3a.2; WBGene00015293. [Q11090-1]
DR EnsemblMetazoa; C01C4.3a.3; C01C4.3a.3; WBGene00015293. [Q11090-1]
DR EnsemblMetazoa; C01C4.3a.4; C01C4.3a.4; WBGene00015293. [Q11090-1]
DR EnsemblMetazoa; C01C4.3b.1; C01C4.3b.1; WBGene00015293. [Q11090-2]
DR EnsemblMetazoa; C01C4.3b.2; C01C4.3b.2; WBGene00015293. [Q11090-2]
DR UCSC; C01C4.3b; c. elegans. [Q11090-1]
DR WormBase; C01C4.3a; CE03889; WBGene00015293; -. [Q11090-1]
DR WormBase; C01C4.3b; CE30846; WBGene00015293; -. [Q11090-2]
DR eggNOG; KOG1345; Eukaryota.
DR HOGENOM; CLU_000288_10_3_1; -.
DR InParanoid; Q11090; -.
DR OMA; YYVMIDT; -.
DR OrthoDB; 1221624at2759; -.
DR PhylomeDB; Q11090; -.
DR PRO; PR:Q11090; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00015293; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q11090; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Kinase; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..407
FT /note="Putative serine/threonine-protein kinase C01C4.3"
FT /id="PRO_0000086844"
FT DOMAIN 126..397
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 33..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 251
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 132..140
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 155
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT VAR_SEQ 1..113
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_009624"
FT VAR_SEQ 402..407
FT /note="VAVPYY -> RPEEDYYVMIDTASKSRQTATSSSGEPQDPSAPAAEQRKQKS
FT TLQQWISTTLTAMAEISEQVVSARDD (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_009625"
SQ SEQUENCE 407 AA; 47364 MW; FD929C7F938433FA CRC64;
MTPEKTKEVF QMFKGAPTRR KSENAHSHRV VLNQLQNHPP RNATQSPQRQ PRTSESSMDF
PRSALRRNST DTHVFANRTH NHRDINVPAC SSEEDRVSTA RRNSLFVKRG SVTMEPIKKV
DLEEVYTVNK QLGTGRFGFI KLAEHKQSKQ RIAIKFFPRP QTKQADFVRE YNYSFFLSPH
QNIIDTYEGM FQSSDDTAYF FVQEFCPRAS LREAVEATNQ AGIGEANTKK VFAAVLSAIE
FMHDENLVHR NLKAENILIF DANDYSKVKV TDFGLTRKVD TTVKYLEYVN NYHAAELCDT
VVNEKLVVNK STDIWALGII FFYCMKGKFP WQKASIMCKP YWEWEQWLKR KNPALPKKFN
PFSEKALKLF KKSLTPRFKD RWTAKDMRKC LAKEKLLKSV KVAVPYY
