YX05_CAEEL
ID YX05_CAEEL Reviewed; 328 AA.
AC Q11112;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Putative tyrosine-protein kinase C03B1.5;
DE EC=2.7.10.2;
GN ORFNames=C03B1.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; FO080304; CCD62741.1; -; Genomic_DNA.
DR PIR; T15383; T15383.
DR RefSeq; NP_509065.2; NM_076664.4.
DR AlphaFoldDB; Q11112; -.
DR SMR; Q11112; -.
DR STRING; 6239.C03B1.5; -.
DR PaxDb; Q11112; -.
DR EnsemblMetazoa; C03B1.5.1; C03B1.5.1; WBGene00015376.
DR GeneID; 182148; -.
DR KEGG; cel:CELE_C03B1.5; -.
DR UCSC; C03B1.5; c. elegans.
DR CTD; 182148; -.
DR WormBase; C03B1.5; CE37605; WBGene00015376; -.
DR eggNOG; KOG0201; Eukaryota.
DR GeneTree; ENSGT00980000202013; -.
DR HOGENOM; CLU_897814_0_0_1; -.
DR InParanoid; Q11112; -.
DR OMA; VQMCLEY; -.
DR OrthoDB; 1721831at2759; -.
DR PhylomeDB; Q11112; -.
DR PRO; PR:Q11112; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00015376; Expressed in embryo and 2 other tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase;
KW Tyrosine-protein kinase.
FT CHAIN 1..328
FT /note="Putative tyrosine-protein kinase C03B1.5"
FT /id="PRO_0000088187"
FT DOMAIN 25..288
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 155
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 31..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 62
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 328 AA; 37213 MW; B709F2DA658F309F CRC64;
MQSAQKSKTN GDTSLFLMKD IPQYWSPALK IGSGAFGEVM LVHSDRLDAR GEQILHNEFA
LKVIRFPECD YHKIIREVNT HTLCRHHDNV LFIGSIYCQT FQQGLRVQMC LEYAALSDLS
LLASSETFES HVAYICKNLI SALIHIHNLG IVHGDLSVKN ILMTHEGVVK LSDFGMANTF
EQTRKSKNQS ILGTPGFIAP EIINLQGYDG KADLWGLGIL SLFLLKGENP FKKCTQFDLE
SYKVSISESF YPDYSNYSTP LQEFMSSLKD YNPEFRSSAL HASSQTYLKT SCSQSEILNY
YKRLRRTRGM DLPWPEEIHT FSVPVSLE
