ID   YXAL_BACSU              Reviewed;         410 AA.
AC   P42111; O32290; P42110;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2003, sequence version 3.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Uncharacterized protein YxaL;
DE   Flags: Precursor;
GN   Name=yxaL; Synonyms=yxaK; OrderedLocusNames=BSU39940; ORFNames=S14K/S14L;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=7584049; DOI=10.1093/dnares/2.2.61;
RA   Yoshida K., Seki S., Fujimura M., Miwa Y., Fujita Y.;
RT   "Cloning and sequencing of a 36-kb region of the Bacillus subtilis genome
RT   between the gnt and iol operons.";
RL   DNA Res. 2:61-69(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=10568751; DOI=10.1101/gr.9.11.1116;
RA   Medigue C., Rose M., Viari A., Danchin A.;
RT   "Detecting and analyzing DNA sequencing errors: toward a higher quality of
RT   the Bacillus subtilis genome sequence.";
RL   Genome Res. 9:1116-1127(1999).
RN   [4]
RP   PROTEIN SEQUENCE OF 42-52, AND SUBCELLULAR LOCATION.
RC   STRAIN=168;
RX   PubMed=10658653; DOI=10.1099/00221287-146-1-65;
RA   Hirose I., Sano K., Shioda I., Kumano M., Nakamura K., Yamane K.;
RT   "Proteome analysis of Bacillus subtilis extracellular proteins: a two-
RT   dimensional protein electrophoretic study.";
RL   Microbiology 146:65-75(2000).
RN   [5]
RP   FUNCTION, INTERACTION WITH PCRA; PDP; YCLM; YKVL; YHCQ AND YOML, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=12073041; DOI=10.1007/s00438-002-0670-9;
RA   Noirot-Gros M.-F., Soultanas P., Wigley D.B., Ehrlich S.D., Noirot P.,
RA   Petit M.-A.;
RT   "The beta-propeller protein YxaL increases the processivity of the PcrA
RT   helicase.";
RL   Mol. Genet. Genomics 267:391-400(2002).
CC   -!- FUNCTION: Increases the processivity of the PcrA helicase, but does not
CC       bind to DNA. {ECO:0000269|PubMed:12073041}.
CC   -!- SUBUNIT: Interacts with PcrA, Pdp, YclM, YkvL, YhcQ and YomL. The
CC       interaction with PcrA is not essential for cell viability or repair of
CC       UV-induced lesions. {ECO:0000269|PubMed:12073041}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10658653}.
CC   -!- DISRUPTION PHENOTYPE: No PcrA-related phenotype.
CC       {ECO:0000269|PubMed:12073041}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA21591.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB005554; BAA21590.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AB005554; BAA21591.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL009126; CAB16030.2; -; Genomic_DNA.
DR   PIR; B70072; B70072.
DR   PIR; C70072; C70072.
DR   RefSeq; NP_391873.2; NC_000964.3.
DR   RefSeq; WP_003243209.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P42111; -.
DR   SMR; P42111; -.
DR   IntAct; P42111; 10.
DR   STRING; 224308.BSU39940; -.
DR   PaxDb; P42111; -.
DR   PRIDE; P42111; -.
DR   DNASU; 937661; -.
DR   EnsemblBacteria; CAB16030; CAB16030; BSU_39940.
DR   GeneID; 937661; -.
DR   KEGG; bsu:BSU39940; -.
DR   PATRIC; fig|224308.179.peg.4320; -.
DR   eggNOG; COG1520; Bacteria.
DR   InParanoid; P42111; -.
DR   OMA; ERWRFRT; -.
DR   PhylomeDB; P42111; -.
DR   BioCyc; BSUB:BSU39940-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF13360; PQQ_2; 2.
DR   SMART; SM00564; PQQ; 7.
DR   SUPFAM; SSF50998; SSF50998; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..41
FT                   /evidence="ECO:0000269|PubMed:10658653"
FT   CHAIN           42..410
FT                   /note="Uncharacterized protein YxaL"
FT                   /id="PRO_0000050002"
FT   CONFLICT        402..410
FT                   /note="YTKLMAFGK -> SYEADGFWEITE (in Ref. 1; BAA21591)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   410 AA;  43877 MW;  59D37005C8539A31 CRC64;
     MVKSFRMKAL IAGAAVAAAV SAGAVSDVPA AKVLQPTAAY AAETVFSQNN GASGFLPGRY
     DVQAMAPAMF NWSRESRFAG NTDGTLKWQN DIRTTPQNGA GAVIDGDGTV YLHSRDGEMK
     AFNPDGSVKW VTGNLGKTYT QSPVLGTNGV IYLASYDKKI YFIDKETGEI LTTVPLSGGP
     SSETVIGSDG TLYFSTLDNY VHAIKPTSKS TWTERWKLKT NGVVSSVPVL AKNGTVYVGT
     YNYVFYAINS GTGQVKWSRT TSNAFKGYPV IDKDGNIYAG NQDGQLYAYT STGSLKWTFP
     LNGFSSSSPA IDHNGNIYIG SGSGELFSIS KNGDMNWSFY TDGPVRTAPL IDAKGTVYFG
     SDDMKVYAAD ANGNELWSYQ TDSNVVSSPQ LAEDGTLYIG SYTKLMAFGK