ID   YXDL_BACSU              Reviewed;         257 AA.
AC   P42423;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=ABC transporter ATP-binding protein YxdL;
GN   Name=yxdL; OrderedLocusNames=BSU39640; ORFNames=B65F;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=7952181; DOI=10.1099/13500872-140-9-2289;
RA   Yoshida K., Sano H., Miwa Y., Ogasawara N., Fujita Y.;
RT   "Cloning and nucleotide sequencing of a 15 kb region of the Bacillus
RT   subtilis genome containing the iol operon.";
RL   Microbiology 140:2289-2298(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=8867804; DOI=10.1093/dnares/2.6.295;
RA   Yoshida K., Fujimyra M., Yanai N., Fujita Y.;
RT   "Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome
RT   between the iol and hut operons.";
RL   DNA Res. 2:295-301(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   SEQUENCE REVISION TO 219-220.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [5]
RP   INDUCTION, AND POSSIBLE FUNCTION.
RC   STRAIN=168;
RX   PubMed=15289557; DOI=10.1099/mic.0.27155-0;
RA   Joseph P., Guiseppi A., Sorokin A., Denizot F.;
RT   "Characterization of the Bacillus subtilis YxdJ response regulator as the
RT   inducer of expression for the cognate ABC transporter YxdLM.";
RL   Microbiology 150:2609-2617(2004).
RN   [6]
RP   INDUCTION BY LL-37, AND POSSIBLE FUNCTION.
RC   STRAIN=168;
RX   PubMed=15870467; DOI=10.1099/mic.0.27761-0;
RA   Pietiaeinen M., Gardemeister M., Mecklin M., Leskelae S., Sarvas M.,
RA   Kontinen V.P.;
RT   "Cationic antimicrobial peptides elicit a complex stress response in
RT   Bacillus subtilis that involves ECF-type sigma factors and two-component
RT   signal transduction systems.";
RL   Microbiology 151:1577-1592(2005).
CC   -!- FUNCTION: Part of the ABC transporter complex YxdLM which could be
CC       involved in peptide resistance. Responsible for energy coupling to the
CC       transport system (Probable). {ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (YxdL) and
CC       two transmembrane proteins (YxdM). {ECO:0000305}.
CC   -!- INDUCTION: Transcriptionally regulated by YxdJ. Induced by the
CC       antibacterial protein LL-37, probably via YxdJ.
CC       {ECO:0000269|PubMed:15289557, ECO:0000269|PubMed:15870467}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; D14399; BAA03302.1; -; Genomic_DNA.
DR   EMBL; D45912; BAA08315.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16000.2; -; Genomic_DNA.
DR   PIR; A70074; A70074.
DR   RefSeq; NP_391843.2; NC_000964.3.
DR   RefSeq; WP_003243557.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P42423; -.
DR   SMR; P42423; -.
DR   STRING; 224308.BSU39640; -.
DR   TCDB; 3.A.1.134.6; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P42423; -.
DR   PRIDE; P42423; -.
DR   EnsemblBacteria; CAB16000; CAB16000; BSU_39640.
DR   GeneID; 937596; -.
DR   KEGG; bsu:BSU39640; -.
DR   PATRIC; fig|224308.179.peg.4289; -.
DR   eggNOG; COG1136; Bacteria.
DR   InParanoid; P42423; -.
DR   OMA; THCEKSH; -.
DR   PhylomeDB; P42423; -.
DR   BioCyc; BSUB:BSU39640-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..257
FT                   /note="ABC transporter ATP-binding protein YxdL"
FT                   /id="PRO_0000093150"
FT   DOMAIN          5..243
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         40..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CONFLICT        219..220
FT                   /note="GE -> VV (in Ref. 1; BAA03302 and 2; BAA08315)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   257 AA;  28710 MW;  828B01E9ECD9F133 CRC64;
     MANMLEVKHI NKTYKGQVSY QALKQISFSI EEGEFTAVMG PSGSGKTTLL NIISTIDRPD
     SGDILINGEN PHRLKRTKLA HFRRKQLGFV FQDFNLLDTL TIGENIMLPL TLEKEAPSVM
     EEKLHGIAAK LGIENLLNKR TFEVSGGQRQ RAAIARAVIH KPSLILADEP TGNLDSKATK
     DVMETLQSLN RDDHVTALMV THDPVSASYC RRVIFIKDGE LFNEIYRGEN RQVFYEQILD
     VLSMLGGNAN DLSSVRL