YXDM_BACSU
ID YXDM_BACSU Reviewed; 622 AA.
AC P42424;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=ABC transporter permease protein YxdM;
GN Name=yxdM; OrderedLocusNames=BSU39630; ORFNames=B65G;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=8867804; DOI=10.1093/dnares/2.6.295;
RA Yoshida K., Fujimyra M., Yanai N., Fujita Y.;
RT "Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome
RT between the iol and hut operons.";
RL DNA Res. 2:295-301(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 136; 153; 426 AND 513-524.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-404.
RC STRAIN=168 / BGSC1A1;
RX PubMed=7952181; DOI=10.1099/13500872-140-9-2289;
RA Yoshida K., Sano H., Miwa Y., Ogasawara N., Fujita Y.;
RT "Cloning and nucleotide sequencing of a 15 kb region of the Bacillus
RT subtilis genome containing the iol operon.";
RL Microbiology 140:2289-2298(1994).
RN [5]
RP INDUCTION, AND POSSIBLE FUNCTION.
RC STRAIN=168;
RX PubMed=15289557; DOI=10.1099/mic.0.27155-0;
RA Joseph P., Guiseppi A., Sorokin A., Denizot F.;
RT "Characterization of the Bacillus subtilis YxdJ response regulator as the
RT inducer of expression for the cognate ABC transporter YxdLM.";
RL Microbiology 150:2609-2617(2004).
RN [6]
RP INDUCTION BY LL-37, AND POSSIBLE FUNCTION.
RC STRAIN=168;
RX PubMed=15870467; DOI=10.1099/mic.0.27761-0;
RA Pietiaeinen M., Gardemeister M., Mecklin M., Leskelae S., Sarvas M.,
RA Kontinen V.P.;
RT "Cationic antimicrobial peptides elicit a complex stress response in
RT Bacillus subtilis that involves ECF-type sigma factors and two-component
RT signal transduction systems.";
RL Microbiology 151:1577-1592(2005).
CC -!- FUNCTION: Part of the ABC transporter complex YxdLM which could be
CC involved in peptide resistance.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (YxdL) and
CC two transmembrane proteins (YxdM). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Transcriptionally regulated by YxdJ. Induced by the
CC antibacterial protein LL-37, probably via YxdJ.
CC {ECO:0000269|PubMed:15289557, ECO:0000269|PubMed:15870467}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D45912; BAA08316.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15999.2; -; Genomic_DNA.
DR EMBL; D14399; BAA03303.1; -; Genomic_DNA.
DR PIR; B70074; B70074.
DR RefSeq; NP_391842.2; NC_000964.3.
DR RefSeq; WP_003244410.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P42424; -.
DR STRING; 224308.BSU39630; -.
DR TCDB; 3.A.1.134.6; the atp-binding cassette (abc) superfamily.
DR PaxDb; P42424; -.
DR PRIDE; P42424; -.
DR EnsemblBacteria; CAB15999; CAB15999; BSU_39630.
DR GeneID; 937589; -.
DR KEGG; bsu:BSU39630; -.
DR PATRIC; fig|224308.179.peg.4288; -.
DR eggNOG; COG0577; Bacteria.
DR OMA; SAFSIMI; -.
DR PhylomeDB; P42424; -.
DR BioCyc; BSUB:BSU39630-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR027022; ABC_permease_BceB-typ.
DR Pfam; PF02687; FtsX; 1.
DR PIRSF; PIRSF018968; ABC_permease_BceB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..622
FT /note="ABC transporter permease protein YxdM"
FT /id="PRO_0000050011"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 136
FT /note="Y -> I (in Ref. 1; BAA08316 and 3; BAA03303)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="G -> R (in Ref. 1; BAA08316 and 3; BAA03303)"
FT /evidence="ECO:0000305"
FT CONFLICT 426
FT /note="K -> Q (in Ref. 1; BAA08316)"
FT /evidence="ECO:0000305"
FT CONFLICT 513..524
FT /note="AIVFFVAAASFL -> GNCILCRGTSFS (in Ref. 1; BAA08316)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 622 AA; 70477 MW; 193A215B831A1414 CRC64;
MTFLQFAYKN VTRNKRAYLA FFLSSAFSVL IFFTFAMFLF HPALKEGYLN NIAKKGLTAA
EWMIFVFSFL FVLYSVNAFL KSRNKEFGIL LMQGITPGQL RKLITAENMI IGVMSIAAGI
IGGFIFSKTF FTVGAYILEM DALPLYMPWK ALGITACGFL LLFFFLSQFT ILFVRSNTVI
KLIKGTGKVK PEPKPSVLLS LFGIACLCGG YGMVLKGNVH GAEPFIILLL TVIGTYFFFS
QSSIWILRAL KKWKTFYLRG KNIIWVSDLV YRLKDNARLF FIVSIISAVA FTATGVLAMY
KSTVGAEESA YEMEYLSYSN NPKEQTHLKD IDHELKTHGF TYTKDKIDVS YVRYQEGETV
PPVYMISESD AAKYFHVKVN GLKEDEAVYF PGTYDRNFKN EAPDQLKLLN QKGELSDQKL
SVKEVKKPLI SLNAIIAVND QTFDQLKSLG DKASLYGYSY DHWKDSLEIS QSLQNEIYGN
YIDVHSDFAS KAGTYYDTVQ LPSLSLFIGL FIAIVFFVAA ASFLYFRLFT DLDEDRERYR
SLAKIGLSER EMAQSVTIQL AILFFFPFVI AVMHTLFALR TLAVEGYSDV AGPLSLTIGG
FFIFQLLFFL AVRSSYLKKM NK
