YXEA_BACSU
ID YXEA_BACSU Reviewed; 115 AA.
AC P54940;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Uncharacterized protein YxeA;
DE Flags: Precursor;
GN Name=yxeA; OrderedLocusNames=BSU39620; ORFNames=HS74A;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=8867804; DOI=10.1093/dnares/2.6.295;
RA Yoshida K., Fujimyra M., Yanai N., Fujita Y.;
RT "Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome
RT between the iol and hut operons.";
RL DNA Res. 2:295-301(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP INDUCTION.
RC STRAIN=168;
RX PubMed=15289557; DOI=10.1099/mic.0.27155-0;
RA Joseph P., Guiseppi A., Sorokin A., Denizot F.;
RT "Characterization of the Bacillus subtilis YxdJ response regulator as the
RT inducer of expression for the cognate ABC transporter YxdLM.";
RL Microbiology 150:2609-2617(2004).
RN [4]
RP INDUCTION BY LL-37.
RC STRAIN=168;
RX PubMed=15870467; DOI=10.1099/mic.0.27761-0;
RA Pietiaeinen M., Gardemeister M., Mecklin M., Leskelae S., Sarvas M.,
RA Kontinen V.P.;
RT "Cationic antimicrobial peptides elicit a complex stress response in
RT Bacillus subtilis that involves ECF-type sigma factors and two-component
RT signal transduction systems.";
RL Microbiology 151:1577-1592(2005).
CC -!- INDUCTION: Transcriptionally regulated by YxdJ. Induced by the
CC antibacterial protein LL-37, probably via YxdJ.
CC {ECO:0000269|PubMed:15289557, ECO:0000269|PubMed:15870467}.
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DR EMBL; D45912; BAA08317.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15998.1; -; Genomic_DNA.
DR PIR; C70074; C70074.
DR RefSeq; NP_391841.1; NC_000964.3.
DR RefSeq; WP_003227084.1; NZ_JNCM01000034.1.
DR PDB; 3NPP; X-ray; 2.15 A; A/B=30-115.
DR PDBsum; 3NPP; -.
DR AlphaFoldDB; P54940; -.
DR SMR; P54940; -.
DR STRING; 224308.BSU39620; -.
DR PaxDb; P54940; -.
DR PRIDE; P54940; -.
DR DNASU; 937612; -.
DR EnsemblBacteria; CAB15998; CAB15998; BSU_39620.
DR GeneID; 937612; -.
DR KEGG; bsu:BSU39620; -.
DR PATRIC; fig|224308.179.peg.4287; -.
DR eggNOG; COG5294; Bacteria.
DR OMA; FFHNDVT; -.
DR PhylomeDB; P54940; -.
DR BioCyc; BSUB:BSU39620-MON; -.
DR EvolutionaryTrace; P54940; -.
DR Proteomes; UP000001570; Chromosome.
DR Gene3D; 2.40.50.480; -; 1.
DR InterPro; IPR006542; DUF1093.
DR InterPro; IPR036166; YxeA-like_sf.
DR PANTHER; PTHR36433; PTHR36433; 1.
DR Pfam; PF06486; DUF1093; 1.
DR SUPFAM; SSF159121; SSF159121; 1.
DR TIGRFAMs; TIGR01655; yxeA_fam; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..115
FT /note="Uncharacterized protein YxeA"
FT /id="PRO_0000013742"
FT STRAND 30..32
FT /evidence="ECO:0007829|PDB:3NPP"
FT STRAND 37..43
FT /evidence="ECO:0007829|PDB:3NPP"
FT STRAND 49..51
FT /evidence="ECO:0007829|PDB:3NPP"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:3NPP"
FT STRAND 55..63
FT /evidence="ECO:0007829|PDB:3NPP"
FT STRAND 69..78
FT /evidence="ECO:0007829|PDB:3NPP"
FT STRAND 85..91
FT /evidence="ECO:0007829|PDB:3NPP"
FT STRAND 94..101
FT /evidence="ECO:0007829|PDB:3NPP"
FT HELIX 103..105
FT /evidence="ECO:0007829|PDB:3NPP"
FT HELIX 108..114
FT /evidence="ECO:0007829|PDB:3NPP"
SQ SEQUENCE 115 AA; 13018 MW; EA4A05514D896C41 CRC64;
MKKAMAILAV LAAAAVICGL LFFHNDVTDR FNPFIHQQDV YVQIDRDGRH LSPGGTEYTL
DGYNASGKKE EVTFFAGKEL RKNAYLKVKA KGKYVETWEE VKFEDMPDSV QSKLK
