CC113_MOUSE
ID CC113_MOUSE Reviewed; 377 AA.
AC Q8C5T8;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Coiled-coil domain-containing protein 113;
GN Name=Ccdc113;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of centriolar satellites contributing to primary
CC cilium formation. {ECO:0000250|UniProtKB:Q9H0I3}.
CC -!- SUBUNIT: Interacts with HAP1 AND PCM1. {ECO:0000250|UniProtKB:Q9H0I3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriolar satellite
CC {ECO:0000250|UniProtKB:Q9H0I3}. Note=Colocalized with HAP1 at
CC centriolar satellites. Centriolar satellite localization requires PCM1.
CC {ECO:0000250|UniProtKB:Q9H0I3}.
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DR EMBL; AK077130; BAC36633.1; -; mRNA.
DR EMBL; BC060957; AAH60957.1; -; mRNA.
DR CCDS; CCDS22563.1; -.
DR RefSeq; NP_766502.1; NM_172914.2.
DR AlphaFoldDB; Q8C5T8; -.
DR SMR; Q8C5T8; -.
DR STRING; 10090.ENSMUSP00000049497; -.
DR iPTMnet; Q8C5T8; -.
DR PhosphoSitePlus; Q8C5T8; -.
DR MaxQB; Q8C5T8; -.
DR PaxDb; Q8C5T8; -.
DR PRIDE; Q8C5T8; -.
DR ProteomicsDB; 265575; -.
DR Antibodypedia; 54998; 86 antibodies from 15 providers.
DR DNASU; 244608; -.
DR Ensembl; ENSMUST00000041569; ENSMUSP00000049497; ENSMUSG00000036598.
DR GeneID; 244608; -.
DR KEGG; mmu:244608; -.
DR UCSC; uc009myn.1; mouse.
DR CTD; 29070; -.
DR MGI; MGI:3606076; Ccdc113.
DR VEuPathDB; HostDB:ENSMUSG00000036598; -.
DR eggNOG; ENOG502QU7J; Eukaryota.
DR GeneTree; ENSGT00940000154521; -.
DR HOGENOM; CLU_046867_1_0_1; -.
DR InParanoid; Q8C5T8; -.
DR OMA; TCQQHRA; -.
DR OrthoDB; 972324at2759; -.
DR PhylomeDB; Q8C5T8; -.
DR TreeFam; TF328830; -.
DR BioGRID-ORCS; 244608; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8C5T8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8C5T8; protein.
DR Bgee; ENSMUSG00000036598; Expressed in ventricular system choroidal fissure and 53 other tissues.
DR Genevisible; Q8C5T8; MM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0034451; C:centriolar satellite; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR InterPro; IPR025254; DUF4201.
DR Pfam; PF13870; DUF4201; 1.
PE 2: Evidence at transcript level;
KW Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..377
FT /note="Coiled-coil domain-containing protein 113"
FT /id="PRO_0000279400"
FT COILED 95..139
FT /evidence="ECO:0000255"
FT COILED 169..355
FT /evidence="ECO:0000255"
SQ SEQUENCE 377 AA; 44215 MW; CC8F7AD15821CB72 CRC64;
MSEEDSDSVI TDSQAEEEGE LPVIQLCGLV EELSYGNSAL KTETEMFEKY YSRLEPRDHR
MTRLSDIKIT AAEFSQLRSR RKSKARGGLD RTLGLTVEQK LELVQKELED TRDEIRHMRA
NAERDLQHHE AIIEEADIRW NEVQKAVHEF EKDILKTISK KKGSILATQK VMKYIEDMNR
RRDNIKDKLC LKNVSLKVQR KKMLSQLRQK EEVGEALHDV DFQQLKIENA QFLETIEARN
KELIQLKLAS GNTLQVLNTY KNKLHRAMEI YVNLDKEILL RNELLGKIEK ETIQAEEDRA
KAHILNDKLR KQLAEFRAPQ VMMYVKEKIL NGELEKTIKM WERKVEIAEM SLKGYRKAWN
KMKTSDEQLQ IIRPPGK