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CC113_MOUSE
ID   CC113_MOUSE             Reviewed;         377 AA.
AC   Q8C5T8;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Coiled-coil domain-containing protein 113;
GN   Name=Ccdc113;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of centriolar satellites contributing to primary
CC       cilium formation. {ECO:0000250|UniProtKB:Q9H0I3}.
CC   -!- SUBUNIT: Interacts with HAP1 AND PCM1. {ECO:0000250|UniProtKB:Q9H0I3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriolar satellite
CC       {ECO:0000250|UniProtKB:Q9H0I3}. Note=Colocalized with HAP1 at
CC       centriolar satellites. Centriolar satellite localization requires PCM1.
CC       {ECO:0000250|UniProtKB:Q9H0I3}.
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DR   EMBL; AK077130; BAC36633.1; -; mRNA.
DR   EMBL; BC060957; AAH60957.1; -; mRNA.
DR   CCDS; CCDS22563.1; -.
DR   RefSeq; NP_766502.1; NM_172914.2.
DR   AlphaFoldDB; Q8C5T8; -.
DR   SMR; Q8C5T8; -.
DR   STRING; 10090.ENSMUSP00000049497; -.
DR   iPTMnet; Q8C5T8; -.
DR   PhosphoSitePlus; Q8C5T8; -.
DR   MaxQB; Q8C5T8; -.
DR   PaxDb; Q8C5T8; -.
DR   PRIDE; Q8C5T8; -.
DR   ProteomicsDB; 265575; -.
DR   Antibodypedia; 54998; 86 antibodies from 15 providers.
DR   DNASU; 244608; -.
DR   Ensembl; ENSMUST00000041569; ENSMUSP00000049497; ENSMUSG00000036598.
DR   GeneID; 244608; -.
DR   KEGG; mmu:244608; -.
DR   UCSC; uc009myn.1; mouse.
DR   CTD; 29070; -.
DR   MGI; MGI:3606076; Ccdc113.
DR   VEuPathDB; HostDB:ENSMUSG00000036598; -.
DR   eggNOG; ENOG502QU7J; Eukaryota.
DR   GeneTree; ENSGT00940000154521; -.
DR   HOGENOM; CLU_046867_1_0_1; -.
DR   InParanoid; Q8C5T8; -.
DR   OMA; TCQQHRA; -.
DR   OrthoDB; 972324at2759; -.
DR   PhylomeDB; Q8C5T8; -.
DR   TreeFam; TF328830; -.
DR   BioGRID-ORCS; 244608; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q8C5T8; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q8C5T8; protein.
DR   Bgee; ENSMUSG00000036598; Expressed in ventricular system choroidal fissure and 53 other tissues.
DR   Genevisible; Q8C5T8; MM.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0034451; C:centriolar satellite; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR   GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR025254; DUF4201.
DR   Pfam; PF13870; DUF4201; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..377
FT                   /note="Coiled-coil domain-containing protein 113"
FT                   /id="PRO_0000279400"
FT   COILED          95..139
FT                   /evidence="ECO:0000255"
FT   COILED          169..355
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   377 AA;  44215 MW;  CC8F7AD15821CB72 CRC64;
     MSEEDSDSVI TDSQAEEEGE LPVIQLCGLV EELSYGNSAL KTETEMFEKY YSRLEPRDHR
     MTRLSDIKIT AAEFSQLRSR RKSKARGGLD RTLGLTVEQK LELVQKELED TRDEIRHMRA
     NAERDLQHHE AIIEEADIRW NEVQKAVHEF EKDILKTISK KKGSILATQK VMKYIEDMNR
     RRDNIKDKLC LKNVSLKVQR KKMLSQLRQK EEVGEALHDV DFQQLKIENA QFLETIEARN
     KELIQLKLAS GNTLQVLNTY KNKLHRAMEI YVNLDKEILL RNELLGKIEK ETIQAEEDRA
     KAHILNDKLR KQLAEFRAPQ VMMYVKEKIL NGELEKTIKM WERKVEIAEM SLKGYRKAWN
     KMKTSDEQLQ IIRPPGK
 
 
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