CC115_BOVIN
ID CC115_BOVIN Reviewed; 180 AA.
AC Q3SZB5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Coiled-coil domain-containing protein 115;
GN Name=CCDC115;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory component of the proton-transporting vacuolar (V)-
CC ATPase protein pump involved in intracellular iron homeostasis. In
CC aerobic conditions, required for intracellular iron homeostasis, thus
CC triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and
CC leading to HIF1A hydroxylation and subsequent proteasomal degradation.
CC Necessary for endolysosomal acidification and lysosomal degradation (By
CC similarity). May be involved in Golgi homeostasis (By similarity).
CC {ECO:0000250|UniProtKB:Q96NT0}.
CC -!- SUBUNIT: Accessory component of the multisubunit proton-transporting
CC vacuolar (V)-ATPase protein pump. {ECO:0000250|UniProtKB:Q96NT0}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q8VE99}. Lysosome
CC {ECO:0000250|UniProtKB:Q8VE99}. Endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000250|UniProtKB:Q96NT0}. Cytoplasmic
CC vesicle, COPI-coated vesicle {ECO:0000250|UniProtKB:Q96NT0}.
CC Endoplasmic reticulum {ECO:0000250|UniProtKB:Q96NT0}.
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DR EMBL; BC102977; AAI02978.1; -; mRNA.
DR RefSeq; NP_001029616.1; NM_001034444.1.
DR RefSeq; XP_005202235.1; XM_005202178.3.
DR AlphaFoldDB; Q3SZB5; -.
DR SMR; Q3SZB5; -.
DR STRING; 9913.ENSBTAP00000004187; -.
DR PaxDb; Q3SZB5; -.
DR PRIDE; Q3SZB5; -.
DR Ensembl; ENSBTAT00000004187; ENSBTAP00000004187; ENSBTAG00000015841.
DR GeneID; 513406; -.
DR KEGG; bta:513406; -.
DR CTD; 84317; -.
DR VEuPathDB; HostDB:ENSBTAG00000015841; -.
DR eggNOG; ENOG502S392; Eukaryota.
DR GeneTree; ENSGT00390000012929; -.
DR HOGENOM; CLU_107415_0_0_1; -.
DR InParanoid; Q3SZB5; -.
DR OMA; RMEPRVC; -.
DR OrthoDB; 1605528at2759; -.
DR TreeFam; TF324647; -.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000015841; Expressed in metanephros cortex and 103 other tissues.
DR GO; GO:0030137; C:COPI-coated vesicle; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; ISS:UniProtKB.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006879; P:cellular iron ion homeostasis; ISS:UniProtKB.
DR GO; GO:0036295; P:cellular response to increased oxygen levels; ISS:UniProtKB.
DR GO; GO:0007042; P:lysosomal lumen acidification; ISS:UniProtKB.
DR GO; GO:1905146; P:lysosomal protein catabolic process; ISS:UniProtKB.
DR GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IEA:InterPro.
DR InterPro; IPR040357; Vma22/CCDC115.
DR PANTHER; PTHR31996; PTHR31996; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome;
KW Lysosome; Reference proteome.
FT CHAIN 1..180
FT /note="Coiled-coil domain-containing protein 115"
FT /id="PRO_0000279402"
FT REGION 89..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..38
FT /evidence="ECO:0000255"
FT COILED 152..176
FT /evidence="ECO:0000255"
FT COMPBIAS 96..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 180 AA; 20141 MW; 8F94CCEE55237EA7 CRC64;
MASRDLRAEV DFVLLQLLGD LEQLEAKRQA LNARVEEGWL SLSKARYAMG AKSVGPLQYA
SHMEPQVRVG TSESQDGLQK FWMVRAGTQT PEEVGSREAA LRRRKGLPRT PEPDSSPAPQ
NPLKWFGILV PHSLRQAQAS FREGLQLAAD MASLQSRITW GQSQLQELQE KLKQLEPRAP