CC115_DANRE
ID CC115_DANRE Reviewed; 206 AA.
AC Q5EAR6;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Coiled-coil domain-containing protein 115;
GN Name=ccdc115; ORFNames=zgc:113121;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory component of the proton-transporting vacuolar (V)-
CC ATPase protein pump involved in intracellular iron homeostasis. May be
CC involved in Golgi homeostasis. {ECO:0000250|UniProtKB:Q96NT0}.
CC -!- SUBUNIT: Accessory component of the multisubunit proton-transporting
CC vacuolar (V)-ATPase protein pump. {ECO:0000250|UniProtKB:Q96NT0}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q8VE99}. Lysosome
CC {ECO:0000250|UniProtKB:Q8VE99}. Endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000250|UniProtKB:Q96NT0}. Cytoplasmic
CC vesicle, COPI-coated vesicle {ECO:0000250|UniProtKB:Q96NT0}.
CC Endoplasmic reticulum {ECO:0000250|UniProtKB:Q96NT0}.
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DR EMBL; BC090281; AAH90281.1; -; mRNA.
DR RefSeq; NP_001013313.1; NM_001013295.2.
DR AlphaFoldDB; Q5EAR6; -.
DR SMR; Q5EAR6; -.
DR STRING; 7955.ENSDARP00000047014; -.
DR PaxDb; Q5EAR6; -.
DR GeneID; 503608; -.
DR KEGG; dre:503608; -.
DR CTD; 84317; -.
DR ZFIN; ZDB-GENE-050227-20; ccdc115.
DR eggNOG; ENOG502S392; Eukaryota.
DR InParanoid; Q5EAR6; -.
DR OrthoDB; 1605528at2759; -.
DR PhylomeDB; Q5EAR6; -.
DR Reactome; R-DRE-8980692; RHOA GTPase cycle.
DR PRO; PR:Q5EAR6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0030137; C:COPI-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; ISS:UniProtKB.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006879; P:cellular iron ion homeostasis; ISS:UniProtKB.
DR GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IEA:InterPro.
DR InterPro; IPR040357; Vma22/CCDC115.
DR PANTHER; PTHR31996; PTHR31996; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome;
KW Lysosome; Reference proteome.
FT CHAIN 1..206
FT /note="Coiled-coil domain-containing protein 115"
FT /id="PRO_0000279750"
FT REGION 109..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..37
FT /evidence="ECO:0000255"
FT COILED 178..206
FT /evidence="ECO:0000255"
FT COMPBIAS 109..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 23775 MW; 8FC99F7C05B07704 CRC64;
MRVDENLRLD EQLLLFMEQL EALEEKRQRL NSLIEEGWFS IAKARYSMGN KQVSALQYAS
EMQPLAHVET SLLEGGTAEF KCERSENKAE EQKTKTIEDI GAKETGLRRR VHTKQKEVKE
GEQDTDEVKT KTDSPTPEHR NPLKWFGILV PQNLKQAQSA FKEVITLSVE IASLQSTILA
TRKEMQVQMK EKQERTEKAQ LEVKEE
