ID   YXLE_BACSU              Reviewed;          62 AA.
AC   P94373; Q794Y3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Negative regulatory protein YxlE;
GN   Name=yxlE; OrderedLocusNames=BSU38670;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=8969509; DOI=10.1099/13500872-142-11-3113;
RA   Yoshida K., Shindo K., Sano H., Seki S., Fujimura M., Yanai N., Miwa Y.,
RA   Fujita Y.;
RT   "Sequencing of a 65 kb region of the Bacillus subtilis genome containing
RT   the lic and cel loci, and creation of a 177 kb contig covering the gnt-
RT   sacXY region.";
RL   Microbiology 142:3113-3123(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION AS A NEGATIVE REGULATOR OF SIGMA Y.
RC   STRAIN=168 / CU1065;
RX   PubMed=12897008; DOI=10.1128/jb.185.16.4883-4890.2003;
RA   Cao M., Salzberg L., Tsai C.S., Mascher T., Bonilla C., Wang T., Ye R.W.,
RA   Marquez-Magana L., Helmann J.D.;
RT   "Regulation of the Bacillus subtilis extracytoplasmic function protein
RT   sigma(Y) and its target promoters.";
RL   J. Bacteriol. 185:4883-4890(2003).
RN   [4]
RP   INDUCTION.
RC   STRAIN=168;
RX   PubMed=14769884; DOI=10.1093/jb/mvg225;
RA   Tojo S., Matsunaga M., Matsumoto T., Kang C.-M., Yamaguchi H., Asai K.,
RA   Sadaie Y., Yoshida K., Fujita Y.;
RT   "Organization and expression of the Bacillus subtilis sigY operon.";
RL   J. Biochem. 134:935-946(2003).
CC   -!- FUNCTION: Together with YxlD is important for negative regulation of
CC       sigma Y activity. {ECO:0000269|PubMed:12897008}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Expression is sigma Y-dependent. Induced upon nitrogen
CC       starvation. {ECO:0000269|PubMed:14769884}.
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DR   EMBL; D83026; BAA11736.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15893.1; -; Genomic_DNA.
DR   PIR; H70081; H70081.
DR   RefSeq; NP_391746.1; NC_000964.3.
DR   RefSeq; WP_003227293.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P94373; -.
DR   STRING; 224308.BSU38670; -.
DR   PaxDb; P94373; -.
DR   EnsemblBacteria; CAB15893; CAB15893; BSU_38670.
DR   GeneID; 937395; -.
DR   KEGG; bsu:BSU38670; -.
DR   PATRIC; fig|224308.179.peg.4186; -.
DR   eggNOG; ENOG50332VC; Bacteria.
DR   OMA; MIFCLVK; -.
DR   BioCyc; BSUB:BSU38670-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027379; CLS_N.
DR   Pfam; PF13396; PLDc_N; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..62
FT                   /note="Negative regulatory protein YxlE"
FT                   /id="PRO_0000383354"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   62 AA;  7085 MW;  C7ED712729B36D7D CRC64;
     MNISWEMILP LIVLQLALAV FALISCIKEE RTNGPKWMWA AIIVCINIIG PILFFTVGRK
     QR