CC116_HUMAN
ID CC116_HUMAN Reviewed; 613 AA.
AC Q8IYX3; B7Z7H5; Q8N9Y9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-JUL-2018, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Coiled-coil domain-containing protein 116;
GN Name=CCDC116;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=25074808; DOI=10.1242/jcs.157008;
RA Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT "Proteomic analysis of mammalian sperm cells identifies new components of
RT the centrosome.";
RL J. Cell Sci. 127:4128-4133(2014).
CC -!- INTERACTION:
CC Q8IYX3; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-744311, EBI-11745576;
CC Q8IYX3; Q00994: BEX3; NbExp=4; IntAct=EBI-744311, EBI-741753;
CC Q8IYX3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-744311, EBI-3866279;
CC Q8IYX3; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-744311, EBI-5278764;
CC Q8IYX3; Q96NB1: CEP20; NbExp=3; IntAct=EBI-744311, EBI-2872654;
CC Q8IYX3; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-744311, EBI-3866319;
CC Q8IYX3; P68400: CSNK2A1; NbExp=3; IntAct=EBI-744311, EBI-347804;
CC Q8IYX3; P78358: CTAG1B; NbExp=3; IntAct=EBI-744311, EBI-1188472;
CC Q8IYX3; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-744311, EBI-10175124;
CC Q8IYX3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-744311, EBI-5916454;
CC Q8IYX3; O75031: HSF2BP; NbExp=3; IntAct=EBI-744311, EBI-7116203;
CC Q8IYX3; P24592: IGFBP6; NbExp=3; IntAct=EBI-744311, EBI-947015;
CC Q8IYX3; Q15323: KRT31; NbExp=3; IntAct=EBI-744311, EBI-948001;
CC Q8IYX3; Q6A162: KRT40; NbExp=3; IntAct=EBI-744311, EBI-10171697;
CC Q8IYX3; Q99750: MDFI; NbExp=7; IntAct=EBI-744311, EBI-724076;
CC Q8IYX3; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-744311, EBI-18582591;
CC Q8IYX3; Q5JR59: MTUS2; NbExp=4; IntAct=EBI-744311, EBI-742948;
CC Q8IYX3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-744311, EBI-11522433;
CC Q8IYX3; Q96KN3: PKNOX2; NbExp=3; IntAct=EBI-744311, EBI-2692890;
CC Q8IYX3; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-744311, EBI-710402;
CC Q8IYX3; A6NK89: RASSF10; NbExp=3; IntAct=EBI-744311, EBI-6912267;
CC Q8IYX3; O75478: TADA2A; NbExp=5; IntAct=EBI-744311, EBI-742268;
CC Q8IYX3; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-744311, EBI-1105213;
CC Q8IYX3; Q13077: TRAF1; NbExp=6; IntAct=EBI-744311, EBI-359224;
CC Q8IYX3; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-744311, EBI-739895;
CC Q8IYX3; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-744311, EBI-12030590;
CC Q8IYX3; Q8N720: ZNF655; NbExp=3; IntAct=EBI-744311, EBI-625509;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:25074808}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=2;
CC IsoId=Q8IYX3-2; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8IYX3-1; Sequence=VSP_059646;
CC Name=3;
CC IsoId=Q8IYX3-3; Sequence=VSP_059645;
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DR EMBL; AK093365; BAC04145.1; -; mRNA.
DR EMBL; AK302030; BAH13611.1; -; mRNA.
DR EMBL; AP000553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW59466.1; -; Genomic_DNA.
DR EMBL; BC033499; AAH33499.1; -; mRNA.
DR CCDS; CCDS13791.1; -. [Q8IYX3-2]
DR CCDS; CCDS87008.1; -. [Q8IYX3-3]
DR RefSeq; NP_001317995.1; NM_001331066.1. [Q8IYX3-3]
DR RefSeq; NP_689825.2; NM_152612.2. [Q8IYX3-2]
DR AlphaFoldDB; Q8IYX3; -.
DR BioGRID; 127896; 42.
DR IntAct; Q8IYX3; 32.
DR MINT; Q8IYX3; -.
DR STRING; 9606.ENSP00000292779; -.
DR GlyGen; Q8IYX3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IYX3; -.
DR PhosphoSitePlus; Q8IYX3; -.
DR BioMuta; CCDC116; -.
DR DMDM; 117949387; -.
DR MassIVE; Q8IYX3; -.
DR MaxQB; Q8IYX3; -.
DR PaxDb; Q8IYX3; -.
DR PeptideAtlas; Q8IYX3; -.
DR PRIDE; Q8IYX3; -.
DR ProteomicsDB; 71256; -. [Q8IYX3-1]
DR ProteomicsDB; 71257; -. [Q8IYX3-2]
DR Antibodypedia; 218; 69 antibodies from 11 providers.
DR DNASU; 164592; -.
DR Ensembl; ENST00000292779.4; ENSP00000292779.3; ENSG00000161180.11. [Q8IYX3-2]
DR Ensembl; ENST00000607942.5; ENSP00000476296.1; ENSG00000161180.11. [Q8IYX3-3]
DR GeneID; 164592; -.
DR KEGG; hsa:164592; -.
DR MANE-Select; ENST00000292779.4; ENSP00000292779.3; NM_152612.3; NP_689825.2.
DR UCSC; uc002zve.4; human. [Q8IYX3-2]
DR CTD; 164592; -.
DR DisGeNET; 164592; -.
DR GeneCards; CCDC116; -.
DR HGNC; HGNC:26688; CCDC116.
DR HPA; ENSG00000161180; Tissue enriched (testis).
DR neXtProt; NX_Q8IYX3; -.
DR OpenTargets; ENSG00000161180; -.
DR PharmGKB; PA145149301; -.
DR VEuPathDB; HostDB:ENSG00000161180; -.
DR eggNOG; ENOG502STQK; Eukaryota.
DR GeneTree; ENSGT00390000002259; -.
DR HOGENOM; CLU_022190_1_0_1; -.
DR InParanoid; Q8IYX3; -.
DR OMA; HDGCPLF; -.
DR OrthoDB; 694022at2759; -.
DR PhylomeDB; Q8IYX3; -.
DR TreeFam; TF337163; -.
DR PathwayCommons; Q8IYX3; -.
DR SignaLink; Q8IYX3; -.
DR BioGRID-ORCS; 164592; 37 hits in 1077 CRISPR screens.
DR GenomeRNAi; 164592; -.
DR Pharos; Q8IYX3; Tdark.
DR PRO; PR:Q8IYX3; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q8IYX3; protein.
DR Bgee; ENSG00000161180; Expressed in left testis and 84 other tissues.
DR ExpressionAtlas; Q8IYX3; baseline and differential.
DR Genevisible; Q8IYX3; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR031532; DUF4702.
DR PANTHER; PTHR36861; PTHR36861; 1.
DR Pfam; PF15774; DUF4702; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..613
FT /note="Coiled-coil domain-containing protein 116"
FT /id="PRO_0000254052"
FT REGION 41..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..104
FT /evidence="ECO:0000255"
FT COMPBIAS 512..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..613
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V8B5"
FT VAR_SEQ 402..613
FT /note="SPCSSSRFTKKKPLPSISSKSSMSHFSNRLYEELADFLTQQAASLVIRKYEF
FT EKDLSKQLGFFSFPITHVLRDLSLGLKKVKGSRIHLSSETHRSCLLRKLEESKRARQAS
FT RLSTSHCSTETPSVQQEPATHTAQDQATEPCRSLYTNLPASRQLSPLEPKLYMSACTGM
FT GSSPPKSKDMDNEGRDKAEIEDEDEDEFKDEDQDEDKDEDGV -> VTPTEKPNVPSPS
FT LHSREEAPDSDPKLQNPPVSLSSSQRAQPWQGLHLTLPTPGIVVEVACSQGHLRGPVTP
FT PLSSPYPRSSCYLLPELSPVASSSPASLCPEVTSSKVGPGMSLQEKGSLTHHS (in
FT isoform 3)"
FT /id="VSP_059645"
FT VAR_SEQ 509..613
FT /note="RQASRLSTSHCSTETPSVQQEPATHTAQDQATEPCRSLYTNLPASRQLSPLE
FT PKLYMSACTGMGSSPPKSKDMDNEGRDKAEIEDEDEDEFKDEDQDEDKDEDGV -> AA
FT VSLEA (in isoform 1)"
FT /id="VSP_059646"
FT VARIANT 96
FT /note="R -> C (in dbSNP:rs861854)"
FT /id="VAR_028803"
FT VARIANT 121
FT /note="G -> R (in dbSNP:rs371513)"
FT /id="VAR_028804"
FT VARIANT 122
FT /note="R -> W (in dbSNP:rs861853)"
FT /id="VAR_028805"
FT VARIANT 199
FT /note="R -> W (in dbSNP:rs12170285)"
FT /id="VAR_028806"
FT VARIANT 293
FT /note="P -> L (in dbSNP:rs41279987)"
FT /id="VAR_061578"
FT VARIANT 436
FT /note="A -> T (in dbSNP:rs11705259)"
FT /id="VAR_028807"
SQ SEQUENCE 613 AA; 67946 MW; DB4396CBD001BA19 CRC64;
MARCRHHSGY LADDEASHSM CSARVQLPKK PLVPEMRPAC KPGRVPHPPS TCGSSALQGQ
RRNKRHPQPF GHFLDFLTES QVLDSLETVV EKATERMAAM KTEAGVPLVE VQDPVEVPSG
GRRAHARPSL STVHRHRVRP TLCTGHPNNY PSSSSSMSNC HSSLMAGCLG SHSRDSDLGA
QGSLPPVRDK LLLEKNLKRL LQLEREGKGL SQSCSQRDSL LWDSLGSQTS FQWTQEQPLS
WFSGLLGSSS GVPEASEPRP GEQEPIFRKR EFNKEIKSLL SQLESLDLPG YCPLREPHRT
LNFLADHRLF PALQSVVSQA VDKLRGAHCR DGRPLFPTSL EPTSDLPPLG SEPAKPTNGG
QPYASPRPTV SSPKMLQRKR KDRGGSPSMS SAQVATRFKL KSPCSSSRFT KKKPLPSISS
KSSMSHFSNR LYEELADFLT QQAASLVIRK YEFEKDLSKQ LGFFSFPITH VLRDLSLGLK
KVKGSRIHLS SETHRSCLLR KLEESKRARQ ASRLSTSHCS TETPSVQQEP ATHTAQDQAT
EPCRSLYTNL PASRQLSPLE PKLYMSACTG MGSSPPKSKD MDNEGRDKAE IEDEDEDEFK
DEDQDEDKDE DGV
