ID   CC116_MACFA             Reviewed;         528 AA.
AC   Q95LR6; Q95K29;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Coiled-coil domain-containing protein 116;
GN   Name=CCDC116; ORFNames=QtsA-10747, QtsA-19551;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q8IYX3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q95LR6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95LR6-2; Sequence=VSP_021176, VSP_021177;
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DR   EMBL; AB069998; BAB62943.1; -; mRNA.
DR   EMBL; AB071126; BAB64520.1; -; mRNA.
DR   AlphaFoldDB; Q95LR6; -.
DR   SMR; Q95LR6; -.
DR   STRING; 9541.XP_005567924.1; -.
DR   eggNOG; ENOG502STQK; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   InterPro; IPR031532; DUF4702.
DR   PANTHER; PTHR36861; PTHR36861; 1.
DR   Pfam; PF15774; DUF4702; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..528
FT                   /note="Coiled-coil domain-containing protein 116"
FT                   /id="PRO_0000254053"
FT   REGION          43..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          497..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          81..104
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        359..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..429
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         389
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V8B5"
FT   VAR_SEQ         1..35
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12498619"
FT                   /id="VSP_021176"
FT   VAR_SEQ         405..528
FT                   /note="VTPMEKPDIPSPSLHSREKEPDSDPKLQNPPVSLSSRQRAQPWRGLHLTLPA
FT                   PGIVVEVACGQGHLRVVTPPLACPYPHSSCYLLPELSPVTSSSPSSLCPEVTSSKVGPD
FT                   MSLQEKGSLTHHS -> SPRSSGRFTKKKPLPSISSKSSMSHFSNRLYEELADFLTQQA
FT                   ASLLIRKYEFEKDLSRQLSPLEPKLSVSAGTGMGSSLPKSKDTDSEGHDEAEVEDEDED
FT                   EYKDEDQDEDKEEDGVQSLPEPGEEASVSHSVDVGHSDPP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12498619"
FT                   /id="VSP_021177"
FT   CONFLICT        42
FT                   /note="L -> P (in Ref. 1; BAB62943)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        192
FT                   /note="R -> K (in Ref. 1; BAB62943)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        362
FT                   /note="K -> E (in Ref. 1; BAB62943)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        378
FT                   /note="T -> M (in Ref. 1; BAB62943)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   528 AA;  57775 MW;  83396526E7D32166 CRC64;
     MARCRHHSGY VADDEASHSM CSARVQLPKK PLVPEMGPAS KLGHVPHPPS TCGSSALQNQ
     RRNKRHPQPF SHFLDFLTES HVLDSLETVV EKATERMAAM KTEAGVPLVE VQDPVEVPSG
     GRRAHARPSL STVHRHRVRP TLCTGHPNNY PSSSSSMSDS HSSLMAGWLG SHSRDSDLGA
     QGLGSLPPVK DRLLLEKNLK RLLQLERKGK GLSQSCSKRD SLLWDLLGSQ TSFQWTQEQP
     LSWFSELLGS SSGVPEASEP RPGEQEPICK REFNKEIKSL LSQLESLDLP GYCPLREPHR
     TLNFLADHRL FPALQSVVNQ AVDKLRGARC RDGRPLFPTS LEPPSELQVQ RNLPPLGSEP
     AKPTNSGQPH PTVSSPKTPQ RKHKDRGGSP SMSSAQVATR FKLKVTPMEK PDIPSPSLHS
     REKEPDSDPK LQNPPVSLSS RQRAQPWRGL HLTLPAPGIV VEVACGQGHL RVVTPPLACP
     YPHSSCYLLP ELSPVTSSSP SSLCPEVTSS KVGPDMSLQE KGSLTHHS