CC116_MOUSE
ID CC116_MOUSE Reviewed; 541 AA.
AC Q80X53; Q6PFY7; Q9D5J4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Coiled-coil domain-containing protein 116;
GN Name=Ccdc116;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q8IYX3}.
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DR EMBL; AK015290; BAB29781.1; -; mRNA.
DR EMBL; BC050881; AAH50881.1; -; mRNA.
DR EMBL; BC057359; AAH57359.1; -; mRNA.
DR CCDS; CCDS27995.1; -.
DR RefSeq; NP_001293098.1; NM_001306169.1.
DR RefSeq; NP_084055.2; NM_029779.2.
DR RefSeq; XP_017172647.1; XM_017317158.1.
DR AlphaFoldDB; Q80X53; -.
DR SMR; Q80X53; -.
DR STRING; 10090.ENSMUSP00000111376; -.
DR iPTMnet; Q80X53; -.
DR PhosphoSitePlus; Q80X53; -.
DR PaxDb; Q80X53; -.
DR PRIDE; Q80X53; -.
DR ProteomicsDB; 279938; -.
DR Antibodypedia; 218; 69 antibodies from 11 providers.
DR DNASU; 76872; -.
DR Ensembl; ENSMUST00000023452; ENSMUSP00000023452; ENSMUSG00000022768.
DR Ensembl; ENSMUST00000115711; ENSMUSP00000111376; ENSMUSG00000022768.
DR Ensembl; ENSMUST00000232033; ENSMUSP00000155923; ENSMUSG00000022768.
DR GeneID; 76872; -.
DR KEGG; mmu:76872; -.
DR UCSC; uc007ykd.1; mouse.
DR CTD; 164592; -.
DR MGI; MGI:1924122; Ccdc116.
DR VEuPathDB; HostDB:ENSMUSG00000022768; -.
DR eggNOG; ENOG502STQK; Eukaryota.
DR GeneTree; ENSGT00390000002259; -.
DR HOGENOM; CLU_022190_1_0_1; -.
DR InParanoid; Q80X53; -.
DR OMA; HDGCPLF; -.
DR OrthoDB; 694022at2759; -.
DR PhylomeDB; Q80X53; -.
DR TreeFam; TF337163; -.
DR BioGRID-ORCS; 76872; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q80X53; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q80X53; protein.
DR Bgee; ENSMUSG00000022768; Expressed in spermatid and 41 other tissues.
DR ExpressionAtlas; Q80X53; baseline and differential.
DR Genevisible; Q80X53; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR031532; DUF4702.
DR PANTHER; PTHR36861; PTHR36861; 1.
DR Pfam; PF15774; DUF4702; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..541
FT /note="Coiled-coil domain-containing protein 116"
FT /id="PRO_0000254054"
FT REGION 346..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..102
FT /evidence="ECO:0000255"
FT COMPBIAS 346..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 394
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V8B5"
FT CONFLICT 144
FT /note="R -> C (in Ref. 2; AAH57359)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="L -> Q (in Ref. 1; BAB29781)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 541 AA; 59879 MW; 14C8C5CE790130FD CRC64;
MARCRHHSGY LADDEAAHST YVAPLPKKHL LPEMRPTCKL GRVPHLPSMN QYSEHQSHQQ
NFRHPLAFGG FLDFLTEGQV LDSLQTVVEQ ATERLAAMKT EAGVPLVDIQ DPVEVPSSRH
RSRARPSIDT VHRHRARPTL CAGRPNNYPS CSSSMSDSHS SITAGWLGSH SQDSDLGARG
IGSLPPMRDK LLLEKNLKRL LRLENKGKIL NQSCSQRDSL LWDSLGSQTS SQWTREQPLS
WFSGLLGSSP ATPETSELGL GEQEMIFLKQ KLNKEMKSLL NQPRPFNLPT YCPLREPHHT
LDFLAKHRLF PALQRVVSQA VDKLSHACRH NGFPLFPVTS ETIPDLPGNS DLLQPSSKAS
IPTNREARGE PCDSLTTAYS PKTSHRKSKG RRGSPPNAVQ MATRFRLKVT PTQVSNVPIS
SFHSMQEAPN SEPKLQKQAM ASNCNHISQP CHGLHLTLPA PGITVEVASC QGRLRGPVQH
RLASPCCLHS HFPFPLFPPF LSLGKSFSTS PPTLHPEVTS RAGLEVLEQP LKGRGSFTHH
F
