ID   YYAE_BACSU              Reviewed;         667 AA.
AC   P37519;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Probable oxidoreductase YyaE;
DE            EC=1.-.-.-;
GN   Name=yyaE; OrderedLocusNames=BSU40930;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA   Ogasawara N., Nakai S., Yoshikawa H.;
RT   "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT   chromosome containing the replication origin.";
RL   DNA Res. 1:1-14(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-425.
RC   STRAIN=168 / CRK2000;
RX   PubMed=1552862; DOI=10.1111/j.1365-2958.1992.tb01510.x;
RA   Ogasawara N., Yoshikawa H.;
RT   "Genes and their organization in the replication origin region of the
RT   bacterial chromosome.";
RL   Mol. Microbiol. 6:629-634(1992).
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000250};
CC       Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-
CC       bis-MGD) cofactor per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000305}.
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DR   EMBL; D26185; BAA05223.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16130.1; -; Genomic_DNA.
DR   EMBL; X62539; CAA44413.1; -; Genomic_DNA.
DR   PIR; S66017; S66017.
DR   RefSeq; NP_391973.1; NC_000964.3.
DR   RefSeq; WP_003244290.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P37519; -.
DR   SMR; P37519; -.
DR   STRING; 224308.BSU40930; -.
DR   PaxDb; P37519; -.
DR   PRIDE; P37519; -.
DR   EnsemblBacteria; CAB16130; CAB16130; BSU_40930.
DR   GeneID; 937914; -.
DR   KEGG; bsu:BSU40930; -.
DR   PATRIC; fig|224308.179.peg.4434; -.
DR   eggNOG; COG0243; Bacteria.
DR   InParanoid; P37519; -.
DR   OMA; KPWVRHA; -.
DR   PhylomeDB; P37519; -.
DR   BioCyc; BSUB:BSU40930-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0030151; F:molybdenum ion binding; IBA:GO_Central.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0009061; P:anaerobic respiration; IBA:GO_Central.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE   3: Inferred from homology;
KW   Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..667
FT                   /note="Probable oxidoreductase YyaE"
FT                   /id="PRO_0000050051"
FT   DOMAIN          2..59
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         9
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         13
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         17
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
FT   BINDING         45
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01004"
SQ   SEQUENCE   667 AA;  73936 MW;  3D1CA3709D85CF70 CRC64;
     MSKVHQSACP LNCWDSCGFL VTVDDGKVTK VDGDPNHPIT EGKICGRGRM LETKTNSPDR
     LRYPMKKQNG EFVRISWEQA LDEIADKLRE IKETSETTAV LHSHDYANNG LLKALDQRFF
     NGYGGVTEIV GSICWGSGIE AQSWDFGRSY GHGPLDIYNS KHVVVWGRNV SRTNMHLYHH
     LQQVKKKGAT ITVIDPIFNP TAKLADRYIS VKPGMDGWLA AAVLKVLIEM GRTDETFISE
     HSVGFDDVKE LLKTVSLEEF IVKTETSMEE LEYLAGLYAD GPVSTFMGLG MQRYKNGGGT
     IRWIDALVAA SGNVGIKGGG ANFGNVQIGE SFAKTKLTLP ELKTTSRSFS MMTQAEEVLT
     AADPAIEMII VTCGNPLTQV PNTNKVRQAF EKVPMTVAID SIMTDTAELC DYVLPTATVF
     EEEDIYYSSM YHHYVQYGKK LVEPQGEAKS DSWIWSELAK RLGFGELFEY STQEFLEMGL
     SSLEAEDVTL ERLKEKGHLP LPVKQVPWDD YQFLTPSGKF EFTSSLAEQK GFSGSLQLNV
     PEESVFHNEE LAGKYPYTLL SIHPQRSNHS QHVPFIEKLQ HVQVDISPDI AAGQDLQDGD
     EVVIFNDRGS MKGKVKVMKQ AHAKTINIDE GMWAAFGGSV NALTNDTNSD NGMGSTLFDC
     LVGLKKA