YYAJ_BACSU
ID YYAJ_BACSU Reviewed; 451 AA.
AC P37514; Q45644;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Putative metabolite transport protein YyaJ;
GN Name=yyaJ; OrderedLocusNames=BSU40840;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA Ogasawara N., Nakai S., Yoshikawa H.;
RT "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT chromosome containing the replication origin.";
RL DNA Res. 1:1-14(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BD99;
RX PubMed=8011666; DOI=10.1016/0005-2728(94)90131-7;
RA Quirk P.G., Guffanti A.A., Clejan S., Cheng J., Krulwich T.A.;
RT "Isolation of Tn917 insertional mutants of Bacillus subtilis that are
RT resistant to the protonophore carbonyl cyanide m-chlorophenylhydrazone.";
RL Biochim. Biophys. Acta 1186:27-34(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 141.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; D26185; BAA05214.1; -; Genomic_DNA.
DR EMBL; L16865; AAA64342.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB16121.2; -; Genomic_DNA.
DR PIR; S66008; S66008.
DR RefSeq; NP_391964.2; NC_000964.3.
DR RefSeq; WP_003243011.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P37514; -.
DR SMR; P37514; -.
DR IntAct; P37514; 9.
DR STRING; 224308.BSU40840; -.
DR TCDB; 2.A.1.1.113; the major facilitator superfamily (mfs).
DR PaxDb; P37514; -.
DR PRIDE; P37514; -.
DR EnsemblBacteria; CAB16121; CAB16121; BSU_40840.
DR GeneID; 937884; -.
DR KEGG; bsu:BSU40840; -.
DR PATRIC; fig|224308.179.peg.4425; -.
DR eggNOG; COG0477; Bacteria.
DR eggNOG; COG2814; Bacteria.
DR InParanoid; P37514; -.
DR OMA; QIWIIWL; -.
DR PhylomeDB; P37514; -.
DR BioCyc; BSUB:BSU40840-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..451
FT /note="Putative metabolite transport protein YyaJ"
FT /id="PRO_0000050493"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 355..357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..421
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..451
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 2
FT /note="N -> K (in Ref. 2; AAA64342)"
FT /evidence="ECO:0000305"
FT CONFLICT 21
FT /note="D -> G (in Ref. 2; AAA64342)"
FT /evidence="ECO:0000305"
FT CONFLICT 60
FT /note="H -> N (in Ref. 2; AAA64342)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="A -> S (in Ref. 2; AAA64342)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="A -> P (in Ref. 2; AAA64342)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="N -> D (in Ref. 1; BAA05214)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 451 AA; 49671 MW; 980277CFFC499ABC CRC64;
MNTIFKQKNT HPFSNAANRL DRLPISRVHF QVLTALGIVY FFDLADLFTL SNVAPALIEH
WGIPLSTIAN VTAASFLGMF LGASLGGRLS DRIGRKKALN LFVFVFSIAS LCNAAAWDIP
SLMTFRFLTG FGVAAAMVIT NSYLAEFFPS SVRGKYISFC AMIGLIGVPI TNIVSAFVIP
LGSWGWRLVF VWGAVGLIYF FFIHRLEESP RWHENRGEYA KADAILTRIE EQVEKEKGPL
PAASQPKVSE TVKQNAGYAG LLKGRNLKIT IVLSAVWIFE TFGFYGFASW VPSLLKSNGV
TMENTLWYNV LHSVGAPLGA LLGSMISERF QRKWILAASA FLTAIAGLLY GMTFIPIMII
VFGFIVNITE RVFTSNLYAY TSEPYPTEYR SSGSGLAYGL GRFSNIFGSL LVGFIAVQLG
YISVFLFIGG CWLACSLLLI FFGPNTNAKQ I
