CC117_MOUSE
ID CC117_MOUSE Reviewed; 277 AA.
AC Q6PB51; Q8K217; Q99LL1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Coiled-coil domain-containing protein 117 {ECO:0000305};
GN Name=Ccdc117 {ECO:0000312|MGI:MGI:2144383};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-47, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [5]
RP DEVELOPMENTAL STAGE.
RX PubMed=30742009; DOI=10.1038/s41598-019-39078-5;
RA Horton A.J., Brooker J., Streitfeld W.S., Flessa M.E., Pillai B.,
RA Simpson R., Clark C.D., Gooz M.B., Sutton K.K., Foley A.C., Lee K.H.;
RT "Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and
RT Proliferation.";
RL Sci. Rep. 9:1738-1738(2019).
CC -!- FUNCTION: Facilitates DNA repair, cell cycle progression, and cell
CC proliferation through its interaction with CIAO2B.
CC {ECO:0000250|UniProtKB:Q8IWD4}.
CC -!- SUBUNIT: Interacts with CIAO2B; the interaction is direct. Interacts
CC with MMS19; the interaction is indirect.
CC {ECO:0000250|UniProtKB:Q8IWD4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:Q8IWD4}. Nucleus {ECO:0000250|UniProtKB:Q8IWD4}.
CC Note=Mitotic spindle. {ECO:0000250|UniProtKB:Q8IWD4}.
CC -!- DEVELOPMENTAL STAGE: Firstly detected at E8.5 in pharyngeal arch
CC regions, particularly in the first arch, and in developing outflow
CC tract (OFT) regions. Expression continued through E9.5 in the cardiac
CC outflow tract and atria, and in second heart field (SHF)-containing
CC pharyngeal arch with additional expression in lower craniofacial
CC regions. Also expressed in the developing outflow tract and SHF-
CC associated pharyngeal mesoderm, with additional expression observed in
CC pharyngeal endoderm, outflow tract endocardium and ventral neural tube
CC populations. {ECO:0000269|PubMed:30742009}.
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DR EMBL; AL662876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003203; AAH03203.1; -; mRNA.
DR EMBL; BC034558; AAH34558.1; -; mRNA.
DR EMBL; BC059888; AAH59888.1; -; mRNA.
DR CCDS; CCDS24401.1; -.
DR RefSeq; NP_598794.2; NM_134033.2.
DR AlphaFoldDB; Q6PB51; -.
DR STRING; 10090.ENSMUSP00000020776; -.
DR iPTMnet; Q6PB51; -.
DR PhosphoSitePlus; Q6PB51; -.
DR EPD; Q6PB51; -.
DR MaxQB; Q6PB51; -.
DR PaxDb; Q6PB51; -.
DR PeptideAtlas; Q6PB51; -.
DR PRIDE; Q6PB51; -.
DR ProteomicsDB; 281239; -.
DR Antibodypedia; 226; 119 antibodies from 18 providers.
DR DNASU; 104479; -.
DR Ensembl; ENSMUST00000020776; ENSMUSP00000020776; ENSMUSG00000020482.
DR GeneID; 104479; -.
DR KEGG; mmu:104479; -.
DR UCSC; uc007hwp.2; mouse.
DR CTD; 150275; -.
DR MGI; MGI:2144383; Ccdc117.
DR VEuPathDB; HostDB:ENSMUSG00000020482; -.
DR eggNOG; ENOG502S42Q; Eukaryota.
DR GeneTree; ENSGT00390000005772; -.
DR HOGENOM; CLU_083045_0_0_1; -.
DR InParanoid; Q6PB51; -.
DR OMA; PPDDPFC; -.
DR OrthoDB; 1370565at2759; -.
DR PhylomeDB; Q6PB51; -.
DR TreeFam; TF335674; -.
DR BioGRID-ORCS; 104479; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc117; mouse.
DR PRO; PR:Q6PB51; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6PB51; protein.
DR Bgee; ENSMUSG00000020482; Expressed in secondary oocyte and 217 other tissues.
DR Genevisible; Q6PB51; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072686; C:mitotic spindle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
DR InterPro; IPR031630; CCDC117.
DR PANTHER; PTHR36128; PTHR36128; 1.
DR Pfam; PF15810; CCDC117; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..277
FT /note="Coiled-coil domain-containing protein 117"
FT /id="PRO_0000254139"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 139..166
FT /evidence="ECO:0000255"
FT MOD_RES 47
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWD4"
FT CONFLICT 40
FT /note="L -> P (in Ref. 2; AAH34558)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="T -> A (in Ref. 2; AAH34558)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 277 AA; 30427 MW; 843F0B177573F017 CRC64;
MAALGRPFSG LPLSGSADFL QPPPAFAGRA FPPGAAGHDL APRPGVRGAP SSPGGRTARG
RVSIHCRKKH KRLAEDDECP VRKKRLTEAE LGAVTDEWAL GAHQGREGHG VNTCPSSLSM
PSMLDVVCEE MDQTTGEPQC EVARRRLQEI EDRIIDEDEE VESDRNVSHL PSLVLSDTMK
TGLKREFDEV FTKRMIESMS RPSMELVLWK PLPELLPEKP KPSSSPKNYR RESQAKHAAP
GTAFPQRTEG LLEPQCADAP LYRSLEAATS TEEEMEL
