ID   CC117_RAT               Reviewed;         277 AA.
AC   Q5M9G5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Coiled-coil domain-containing protein 117 {ECO:0000305};
GN   Name=Ccdc117 {ECO:0000312|RGD:1561762};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Facilitates DNA repair, cell cycle progression, and cell
CC       proliferation through its interaction with CIAO2B.
CC       {ECO:0000250|UniProtKB:Q8IWD4}.
CC   -!- SUBUNIT: Interacts with CIAO2B; the interaction is direct. Interacts
CC       with MMS19; the interaction is indirect.
CC       {ECO:0000250|UniProtKB:Q8IWD4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q8IWD4}. Nucleus {ECO:0000250|UniProtKB:Q8IWD4}.
CC       Note=Mitotic spindle. {ECO:0000250|UniProtKB:Q8IWD4}.
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DR   EMBL; BC087119; AAH87119.1; -; mRNA.
DR   RefSeq; NP_001017502.1; NM_001017502.1.
DR   AlphaFoldDB; Q5M9G5; -.
DR   STRING; 10116.ENSRNOP00000015627; -.
DR   iPTMnet; Q5M9G5; -.
DR   PhosphoSitePlus; Q5M9G5; -.
DR   PaxDb; Q5M9G5; -.
DR   Ensembl; ENSRNOT00000015627; ENSRNOP00000015627; ENSRNOG00000010706.
DR   GeneID; 498404; -.
DR   KEGG; rno:498404; -.
DR   UCSC; RGD:1561762; rat.
DR   CTD; 150275; -.
DR   RGD; 1561762; Ccdc117.
DR   eggNOG; ENOG502S42Q; Eukaryota.
DR   GeneTree; ENSGT00390000005772; -.
DR   HOGENOM; CLU_083045_0_0_1; -.
DR   InParanoid; Q5M9G5; -.
DR   OMA; PPDDPFC; -.
DR   OrthoDB; 1370565at2759; -.
DR   PhylomeDB; Q5M9G5; -.
DR   TreeFam; TF335674; -.
DR   PRO; PR:Q5M9G5; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000010706; Expressed in stomach and 20 other tissues.
DR   Genevisible; Q5M9G5; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0072686; C:mitotic spindle; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
DR   InterPro; IPR031630; CCDC117.
DR   PANTHER; PTHR36128; PTHR36128; 1.
DR   Pfam; PF15810; CCDC117; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..277
FT                   /note="Coiled-coil domain-containing protein 117"
FT                   /id="PRO_0000254140"
FT   REGION          22..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          139..166
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        221..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         47
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PB51"
FT   MOD_RES         52
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IWD4"
SQ   SEQUENCE   277 AA;  30360 MW;  49CD6A76D8F00720 CRC64;
     MAALGRPFSG LPLSGSADFL QSPPAFAGRA FPPGAAGHDL APRPGVRGPP SSPDGRTARG
     RVSIHCRKKH KRLAEDDECP VRKKRLTEAE LGAVADEWVL GTHQGIEGHG VNTCPGGLSV
     PSILDAVCEE MDQTTGEPQC EVARRRLQEI EDRIIDEDEE VESDRNVSHL PSLVLSDTMK
     TGLKREFDEV FTKKMIESMS RPSMELVLWK PLPELLSEKP KPSSNPKNYM GESQTKHTAT
     GTAFPQRTEV LLEPQCTDTP LYHSLETAAS TEEEMEL