ID   YYCR_BACSU              Reviewed;         408 AA.
AC   Q45604; Q794W4;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Uncharacterized zinc-type alcohol dehydrogenase-like protein YycR;
DE            EC=1.-.-.-;
GN   Name=yycR; OrderedLocusNames=BSU40250;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9205843; DOI=10.1093/dnares/4.2.155;
RA   Kasahara Y., Nakai S., Ogasawara N.;
RT   "Sequence analysis of the 36-kb region between gntZ and trnY genes of
RT   Bacillus subtilis genome.";
RL   DNA Res. 4:155-159(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=168;
RX   PubMed=18820069; DOI=10.1128/aem.00881-08;
RA   Nicholson W.L.;
RT   "The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-
RT   butanediol dehydrogenase.";
RL   Appl. Environ. Microbiol. 74:6832-6838(2008).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene retain acetoin
CC       reductase/2,3-butanediol dehydrogenase activity.
CC       {ECO:0000269|PubMed:18820069}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; D78193; BAA11284.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16062.1; -; Genomic_DNA.
DR   PIR; F70090; F70090.
DR   RefSeq; NP_391905.1; NC_000964.3.
DR   RefSeq; WP_003226972.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; Q45604; -.
DR   SMR; Q45604; -.
DR   STRING; 224308.BSU40250; -.
DR   PaxDb; Q45604; -.
DR   PRIDE; Q45604; -.
DR   EnsemblBacteria; CAB16062; CAB16062; BSU_40250.
DR   GeneID; 937754; -.
DR   KEGG; bsu:BSU40250; -.
DR   PATRIC; fig|224308.43.peg.4223; -.
DR   eggNOG; COG1063; Bacteria.
DR   InParanoid; Q45604; -.
DR   OMA; GNCNHRK; -.
DR   PhylomeDB; Q45604; -.
DR   BioCyc; BSUB:BSU40250-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014184; HCHO_DH_non_GSH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR02819; fdhA_non_GSH; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Oxidoreductase; Reference proteome; Zinc.
FT   CHAIN           1..408
FT                   /note="Uncharacterized zinc-type alcohol dehydrogenase-like
FT                   protein YycR"
FT                   /id="PRO_0000378094"
FT   BINDING         61
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         82
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         112
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         118
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         126
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   408 AA;  42947 MW;  1F2069A25B8F4479 CRC64;
     MGGMALTGNK AVVYKGKGTV AVEDIGYPEL ILRDGPGVPK ANVNRKCEHG VILKVITTNI
     CGSDQHMVRG RTTAPEGLVL GHEITGEVIE TGRDVEFIKK GDIVSVPFNI ACGRCVMCKT
     QKTHVCLNVN PDRPGSAYGY VDMGGWVGGQ SEYVMVPYAD FQLLVFPDKE QALEKILDLT
     MLSDIFPTGF HGAYTAGVQT GSTVYIAGAG PVGLAAAHSA QLLGASTVIV GDLNEDRLAQ
     ARSFGCETVN VQKHDRLGEQ IEQILGEPTV DAAVDCVGFE ASGHGNQGEA PAAVLNSIMD
     VTQVGGSLGI PGLYVTEDPG AKDADAKTGS LKIRFGLGWA KAHTFVTGQT PAMTYNRNLM
     KAILSGRAQI AKAVNATVIS LDDAPKGYSD FDKGAAKKFV IDPHGTLK