ID   YYDF_BACSU              Reviewed;          49 AA.
AC   Q45596; Q794W9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Putative exported peptide YydF;
GN   Name=yydF; OrderedLocusNames=BSU40180;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9205843; DOI=10.1093/dnares/4.2.155;
RA   Kasahara Y., Nakai S., Ogasawara N.;
RT   "Sequence analysis of the 36-kb region between gntZ and trnY genes of
RT   Bacillus subtilis genome.";
RL   DNA Res. 4:155-159(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION.
RX   PubMed=15101989; DOI=10.1111/j.1365-2958.2004.04023.x;
RA   Hamon M.A., Stanley N.R., Britton R.A., Grossman A.D., Lazazzera B.A.;
RT   "Identification of AbrB-regulated genes involved in biofilm formation by
RT   Bacillus subtilis.";
RL   Mol. Microbiol. 52:847-860(2004).
RN   [4]
RP   SUGGESTION OF FUNCTION, INDUCTION, AND OPERON STRUCTURE.
RC   STRAIN=168;
RX   PubMed=17921301; DOI=10.1128/jb.01181-07;
RA   Butcher B.G., Lin Y.-P., Helmann J.D.;
RT   "The yydFGHIJ operon of Bacillus subtilis encodes a peptide that induces
RT   the LiaRS two-component system.";
RL   J. Bacteriol. 189:8616-8625(2007).
CC   -!- FUNCTION: Suggested to be the precursor for an exported, modified
CC       peptide that has antimicrobial and/or signaling properties. Synthesis
CC       requires YydG and YydH; the peptide is proposed to be exported by the
CC       YydIJ transporter. In the absence of the transporter, the modified
CC       peptide activates the LiaRS two-component regulatory system, possibly
CC       by eliciting cell envelope stress. This activation can occur in trans
CC       in cocultured cells lacking either the transporter or the whole operon.
CC   -!- INDUCTION: Repressed by AbrB. Induced in stationary phase in LB (rich)
CC       medium; the transcript is present in log phase cells grown in modified
CC       competence (MC) and MM media. {ECO:0000269|PubMed:15101989,
CC       ECO:0000269|PubMed:17921301}.
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DR   EMBL; D78193; BAA11276.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16055.1; -; Genomic_DNA.
DR   PIR; D70091; D70091.
DR   RefSeq; NP_391898.1; NC_000964.3.
DR   RefSeq; WP_003226979.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; Q45596; -.
DR   STRING; 224308.BSU40180; -.
DR   PaxDb; Q45596; -.
DR   PRIDE; Q45596; -.
DR   EnsemblBacteria; CAB16055; CAB16055; BSU_40180.
DR   GeneID; 937753; -.
DR   KEGG; bsu:BSU40180; -.
DR   PATRIC; fig|224308.179.peg.4346; -.
DR   BioCyc; BSUB:BSU40180-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   InterPro; IPR023898; YydF/SAG_2028.
DR   TIGRFAMs; TIGR04077; expor_sig_YdyF; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..49
FT                   /note="Putative exported peptide YydF"
FT                   /id="PRO_0000370197"
SQ   SEQUENCE   49 AA;  5781 MW;  BA5F90DAD2982A86 CRC64;
     MKKEITNNET VKNLEFKGLL DESQKLAKVN DLWYFVKSKE NRWILGSGH