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CC121_HUMAN
ID   CC121_HUMAN             Reviewed;         278 AA.
AC   Q6ZUS5; B3KW66; J3KQZ8; Q9H8G6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Coiled-coil domain-containing protein 121;
GN   Name=CCDC121;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta, and Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q6ZUS5; P37198: NUP62; NbExp=4; IntAct=EBI-2836982, EBI-347978;
CC       Q6ZUS5; Q6NUQ1: RINT1; NbExp=4; IntAct=EBI-2836982, EBI-726876;
CC       Q6ZUS5; Q9UBB9: TFIP11; NbExp=7; IntAct=EBI-2836982, EBI-1105213;
CC       Q6ZUS5; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-2836982, EBI-739895;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZUS5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZUS5-2; Sequence=VSP_046649;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX93200.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB14651.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK023708; BAB14651.1; ALT_INIT; mRNA.
DR   EMBL; AK124337; BAG54028.1; -; mRNA.
DR   EMBL; AK125354; BAC86143.1; -; mRNA.
DR   EMBL; AC074091; AAX93200.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CH471053; EAX00560.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00561.1; -; Genomic_DNA.
DR   EMBL; BC066936; AAH66936.1; -; mRNA.
DR   EMBL; BC066969; AAH66969.1; -; mRNA.
DR   CCDS; CCDS1759.1; -. [Q6ZUS5-1]
DR   CCDS; CCDS46247.1; -. [Q6ZUS5-2]
DR   RefSeq; NP_001136155.1; NM_001142683.2. [Q6ZUS5-2]
DR   RefSeq; NP_078860.2; NM_024584.4. [Q6ZUS5-1]
DR   AlphaFoldDB; Q6ZUS5; -.
DR   SMR; Q6ZUS5; -.
DR   BioGRID; 122765; 12.
DR   IntAct; Q6ZUS5; 12.
DR   MINT; Q6ZUS5; -.
DR   STRING; 9606.ENSP00000412150; -.
DR   iPTMnet; Q6ZUS5; -.
DR   PhosphoSitePlus; Q6ZUS5; -.
DR   BioMuta; CCDC121; -.
DR   DMDM; 74738330; -.
DR   EPD; Q6ZUS5; -.
DR   MassIVE; Q6ZUS5; -.
DR   PaxDb; Q6ZUS5; -.
DR   PeptideAtlas; Q6ZUS5; -.
DR   PRIDE; Q6ZUS5; -.
DR   ProteomicsDB; 68348; -. [Q6ZUS5-1]
DR   Antibodypedia; 56093; 30 antibodies from 10 providers.
DR   DNASU; 79635; -.
DR   Ensembl; ENST00000324364.4; ENSP00000339087.2; ENSG00000176714.10. [Q6ZUS5-1]
DR   Ensembl; ENST00000394775.3; ENSP00000412150.2; ENSG00000176714.10. [Q6ZUS5-2]
DR   GeneID; 79635; -.
DR   KEGG; hsa:79635; -.
DR   MANE-Select; ENST00000324364.4; ENSP00000339087.2; NM_024584.5; NP_078860.2.
DR   UCSC; uc002rld.4; human. [Q6ZUS5-1]
DR   CTD; 79635; -.
DR   DisGeNET; 79635; -.
DR   GeneCards; CCDC121; -.
DR   HGNC; HGNC:25833; CCDC121.
DR   HPA; ENSG00000176714; Tissue enhanced (testis).
DR   neXtProt; NX_Q6ZUS5; -.
DR   OpenTargets; ENSG00000176714; -.
DR   PharmGKB; PA147358222; -.
DR   VEuPathDB; HostDB:ENSG00000176714; -.
DR   eggNOG; ENOG502RXQ4; Eukaryota.
DR   GeneTree; ENSGT00940000163171; -.
DR   HOGENOM; CLU_047789_0_0_1; -.
DR   InParanoid; Q6ZUS5; -.
DR   OrthoDB; 886956at2759; -.
DR   PhylomeDB; Q6ZUS5; -.
DR   TreeFam; TF350484; -.
DR   PathwayCommons; Q6ZUS5; -.
DR   SignaLink; Q6ZUS5; -.
DR   BioGRID-ORCS; 79635; 15 hits in 1072 CRISPR screens.
DR   GenomeRNAi; 79635; -.
DR   Pharos; Q6ZUS5; Tdark.
DR   PRO; PR:Q6ZUS5; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q6ZUS5; protein.
DR   Bgee; ENSG00000176714; Expressed in secondary oocyte and 129 other tissues.
DR   ExpressionAtlas; Q6ZUS5; baseline and differential.
DR   Genevisible; Q6ZUS5; HS.
DR   InterPro; IPR032777; DUF4515.
DR   Pfam; PF14988; DUF4515; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Coiled-coil domain-containing protein 121"
FT                   /id="PRO_0000286559"
FT   REGION          253..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..30
FT                   /evidence="ECO:0000255"
FT   COILED          105..243
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQF
FT                   RAGPAGTGAGCSLQGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTL
FT                   SELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEM
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_046649"
SQ   SEQUENCE   278 AA;  33061 MW;  DA5E08E7C80198C8 CRC64;
     MTDLNKHIKQ AQTQRKQLLE ESRELHREKL LVQAENRFFL EYLTNKTEEY TEQPEKVWNS
     YLQKSGEIER RRQESASRYA EQISVLKTAL LQKENIQSSL KRKLQAMRDI AILKEKQEKE
     IQTLQEETKK VQAETASKTR EVQAQLLQEK RLLEKQLSEP DRRLLGKRKR RELNMKAQAL
     KLAAKRFIFE YSCGINRENQ QFKKELLQLI EQAQKLTATQ SHLENRKQQL QQEQWYLESL
     IQARQRLQGS HNQCLNRQDV PKTTPSLPQG TKSRINPK
 
 
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