CC121_HUMAN
ID CC121_HUMAN Reviewed; 278 AA.
AC Q6ZUS5; B3KW66; J3KQZ8; Q9H8G6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Coiled-coil domain-containing protein 121;
GN Name=CCDC121;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6ZUS5; P37198: NUP62; NbExp=4; IntAct=EBI-2836982, EBI-347978;
CC Q6ZUS5; Q6NUQ1: RINT1; NbExp=4; IntAct=EBI-2836982, EBI-726876;
CC Q6ZUS5; Q9UBB9: TFIP11; NbExp=7; IntAct=EBI-2836982, EBI-1105213;
CC Q6ZUS5; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-2836982, EBI-739895;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZUS5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZUS5-2; Sequence=VSP_046649;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX93200.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB14651.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK023708; BAB14651.1; ALT_INIT; mRNA.
DR EMBL; AK124337; BAG54028.1; -; mRNA.
DR EMBL; AK125354; BAC86143.1; -; mRNA.
DR EMBL; AC074091; AAX93200.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471053; EAX00560.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00561.1; -; Genomic_DNA.
DR EMBL; BC066936; AAH66936.1; -; mRNA.
DR EMBL; BC066969; AAH66969.1; -; mRNA.
DR CCDS; CCDS1759.1; -. [Q6ZUS5-1]
DR CCDS; CCDS46247.1; -. [Q6ZUS5-2]
DR RefSeq; NP_001136155.1; NM_001142683.2. [Q6ZUS5-2]
DR RefSeq; NP_078860.2; NM_024584.4. [Q6ZUS5-1]
DR AlphaFoldDB; Q6ZUS5; -.
DR SMR; Q6ZUS5; -.
DR BioGRID; 122765; 12.
DR IntAct; Q6ZUS5; 12.
DR MINT; Q6ZUS5; -.
DR STRING; 9606.ENSP00000412150; -.
DR iPTMnet; Q6ZUS5; -.
DR PhosphoSitePlus; Q6ZUS5; -.
DR BioMuta; CCDC121; -.
DR DMDM; 74738330; -.
DR EPD; Q6ZUS5; -.
DR MassIVE; Q6ZUS5; -.
DR PaxDb; Q6ZUS5; -.
DR PeptideAtlas; Q6ZUS5; -.
DR PRIDE; Q6ZUS5; -.
DR ProteomicsDB; 68348; -. [Q6ZUS5-1]
DR Antibodypedia; 56093; 30 antibodies from 10 providers.
DR DNASU; 79635; -.
DR Ensembl; ENST00000324364.4; ENSP00000339087.2; ENSG00000176714.10. [Q6ZUS5-1]
DR Ensembl; ENST00000394775.3; ENSP00000412150.2; ENSG00000176714.10. [Q6ZUS5-2]
DR GeneID; 79635; -.
DR KEGG; hsa:79635; -.
DR MANE-Select; ENST00000324364.4; ENSP00000339087.2; NM_024584.5; NP_078860.2.
DR UCSC; uc002rld.4; human. [Q6ZUS5-1]
DR CTD; 79635; -.
DR DisGeNET; 79635; -.
DR GeneCards; CCDC121; -.
DR HGNC; HGNC:25833; CCDC121.
DR HPA; ENSG00000176714; Tissue enhanced (testis).
DR neXtProt; NX_Q6ZUS5; -.
DR OpenTargets; ENSG00000176714; -.
DR PharmGKB; PA147358222; -.
DR VEuPathDB; HostDB:ENSG00000176714; -.
DR eggNOG; ENOG502RXQ4; Eukaryota.
DR GeneTree; ENSGT00940000163171; -.
DR HOGENOM; CLU_047789_0_0_1; -.
DR InParanoid; Q6ZUS5; -.
DR OrthoDB; 886956at2759; -.
DR PhylomeDB; Q6ZUS5; -.
DR TreeFam; TF350484; -.
DR PathwayCommons; Q6ZUS5; -.
DR SignaLink; Q6ZUS5; -.
DR BioGRID-ORCS; 79635; 15 hits in 1072 CRISPR screens.
DR GenomeRNAi; 79635; -.
DR Pharos; Q6ZUS5; Tdark.
DR PRO; PR:Q6ZUS5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6ZUS5; protein.
DR Bgee; ENSG00000176714; Expressed in secondary oocyte and 129 other tissues.
DR ExpressionAtlas; Q6ZUS5; baseline and differential.
DR Genevisible; Q6ZUS5; HS.
DR InterPro; IPR032777; DUF4515.
DR Pfam; PF14988; DUF4515; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..278
FT /note="Coiled-coil domain-containing protein 121"
FT /id="PRO_0000286559"
FT REGION 253..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..30
FT /evidence="ECO:0000255"
FT COILED 105..243
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQF
FT RAGPAGTGAGCSLQGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTL
FT SELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEM
FT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046649"
SQ SEQUENCE 278 AA; 33061 MW; DA5E08E7C80198C8 CRC64;
MTDLNKHIKQ AQTQRKQLLE ESRELHREKL LVQAENRFFL EYLTNKTEEY TEQPEKVWNS
YLQKSGEIER RRQESASRYA EQISVLKTAL LQKENIQSSL KRKLQAMRDI AILKEKQEKE
IQTLQEETKK VQAETASKTR EVQAQLLQEK RLLEKQLSEP DRRLLGKRKR RELNMKAQAL
KLAAKRFIFE YSCGINRENQ QFKKELLQLI EQAQKLTATQ SHLENRKQQL QQEQWYLESL
IQARQRLQGS HNQCLNRQDV PKTTPSLPQG TKSRINPK