YZ09_AQUAE
ID YZ09_AQUAE Reviewed; 315 AA.
AC O66403;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Probable integrase/recombinase aq_aa09;
GN OrderedLocusNames=aq_aa09;
OS Aquifex aeolicus (strain VF5).
OG Plasmid ece1.
OC Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
CC -!- FUNCTION: May function as an integrase.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR EMBL; AE000667; AAC07955.1; -; Genomic_DNA.
DR RefSeq; NP_046403.1; NC_001880.1.
DR RefSeq; WP_010890549.1; NC_001880.1.
DR AlphaFoldDB; O66403; -.
DR SMR; O66403; -.
DR STRING; 224324.aq_aa09; -.
DR EnsemblBacteria; AAC07955; AAC07955; aq_aa09.
DR KEGG; aae:aq_aa09; -.
DR eggNOG; COG0582; Bacteria.
DR HOGENOM; CLU_930168_0_0_0; -.
DR InParanoid; O66403; -.
DR OMA; NITAHRF; -.
DR OrthoDB; 2072516at2; -.
DR Proteomes; UP000000798; Plasmid ece1.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; -; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration; DNA recombination; DNA-binding; Plasmid;
KW Reference proteome; Viral genome integration; Virus entry into host cell.
FT CHAIN 1..315
FT /note="Probable integrase/recombinase aq_aa09"
FT /id="PRO_0000197573"
FT DOMAIN 1..78
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT DOMAIN 106..313
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 150
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 263
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 266
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 289
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 299
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ SEQUENCE 315 AA; 38088 MW; 67ACB879DB195141 CRC64;
MEHFIDTYLY ELRKVRDEKT IKKKEYLLKH LQDYSEDLPA FDQSEIFSFY EYLKNKNLKE
TTIRDILKEV RLFYEWLQEQ GLNLKFDEKA LKKLFQSKKS QEALKSKKKY YSDDEINLIL
NAIRGAVEGI STKHPIYYIL TIFLLCSGLR ISEAVKVRKK DFEVKRILTE EGEEKEVWFV
KVREGKFGKE RKALIYFFRP EWKRIFEERL KKLKPEDFFF TYAVKYPKSV KVFTLTDKTA
KWFYWKLEKE LREKGYEIEV NAHRFRNTYI TKLATKGFPV NLIADWVGHS KISTTMDVYM
EAEREKQLEA ILERI
