ID   CC124_BOVIN             Reviewed;         223 AA.
AC   Q2TBV6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Coiled-coil domain-containing protein 124;
GN   Name=CCDC124;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for proper progression of late cytokinetic stages.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RASGEF1B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Midbody {ECO:0000250}.
CC       Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase,
CC       and anaphase. Relocates from centrosome to midbody at telophase (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCDC124 family. {ECO:0000305}.
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DR   EMBL; BC109591; AAI09592.1; -; mRNA.
DR   RefSeq; NP_001033612.1; NM_001038523.2.
DR   AlphaFoldDB; Q2TBV6; -.
DR   SMR; Q2TBV6; -.
DR   STRING; 9913.ENSBTAP00000006040; -.
DR   PaxDb; Q2TBV6; -.
DR   PRIDE; Q2TBV6; -.
DR   Ensembl; ENSBTAT00000006040; ENSBTAP00000006040; ENSBTAG00000004604.
DR   Ensembl; ENSBTAT00000069646; ENSBTAP00000069472; ENSBTAG00000004604.
DR   GeneID; 510778; -.
DR   KEGG; bta:510778; -.
DR   CTD; 115098; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004604; -.
DR   VGNC; VGNC:26840; CCDC124.
DR   eggNOG; KOG3223; Eukaryota.
DR   GeneTree; ENSGT00390000012482; -.
DR   HOGENOM; CLU_069723_0_1_1; -.
DR   InParanoid; Q2TBV6; -.
DR   OMA; RHPEKRM; -.
DR   OrthoDB; 1585903at2759; -.
DR   TreeFam; TF105913; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000004604; Expressed in laryngeal cartilage and 109 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR010422; Ccdc124/Oxs1.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR21680; PTHR21680; 1.
DR   Pfam; PF06244; Ccdc124; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Coiled-coil domain-containing protein 124"
FT                   /id="PRO_0000263734"
FT   REGION          1..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          15..82
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        14..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         141
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CT7"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CT7"
SQ   SEQUENCE   223 AA;  26005 MW;  FB63CBEB65997CB0 CRC64;
     MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWR DEDKHVMRKE QRKEEKEKRR
     LEQLERKKET QRLLEEEDSK LKGGKAPRVA ASSKVTRAQI EETLRRDHQH KESPDPAEKA
     KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVTEEA VDRHPERRMR AAYTAFEEAQ
     LPRLKQENPN MRLSQLKQML KKEWLRSPDN PMNQRAVPFN TPK