Z280A_HUMAN
ID Z280A_HUMAN Reviewed; 542 AA.
AC P59817;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 4.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 280A;
DE AltName: Full=3'OY11.1;
DE AltName: Full=Suppressor of hairy wing homolog 1;
DE AltName: Full=Zinc finger protein 636;
GN Name=ZNF280A; Synonyms=SUHW1, ZNF280, ZNF636;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LYS-71; ASN-136; TYR-137;
RP ASN-246; GLY-249; ASN-278; PHE-486 AND ARG-488.
RX PubMed=9074928; DOI=10.1101/gr.7.3.250;
RA Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A.,
RA Schmeits J.L., Wang J., Shimizu N.;
RT "One-megabase sequence analysis of the human immunoglobulin lambda gene
RT locus.";
RL Genome Res. 7:250-261(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a transcription factor.
CC -!- INTERACTION:
CC P59817; Q9NP86: CABP5; NbExp=3; IntAct=EBI-8489342, EBI-10311131;
CC P59817; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-8489342, EBI-750700;
CC P59817; Q9UHY7: ENOPH1; NbExp=5; IntAct=EBI-8489342, EBI-726969;
CC P59817; Q08493-2: PDE4C; NbExp=3; IntAct=EBI-8489342, EBI-12169289;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; D87009; BAA20006.1; -; Genomic_DNA.
DR EMBL; D87011; BAA20008.1; -; Genomic_DNA.
DR EMBL; AC246793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053901; AAH53901.1; -; mRNA.
DR CCDS; CCDS13800.1; -.
DR RefSeq; NP_542778.2; NM_080740.4.
DR AlphaFoldDB; P59817; -.
DR BioGRID; 126180; 14.
DR IntAct; P59817; 11.
DR MINT; P59817; -.
DR STRING; 9606.ENSP00000302855; -.
DR BioMuta; ZNF280A; -.
DR DMDM; 313104252; -.
DR jPOST; P59817; -.
DR MassIVE; P59817; -.
DR MaxQB; P59817; -.
DR PaxDb; P59817; -.
DR PeptideAtlas; P59817; -.
DR PRIDE; P59817; -.
DR ProteomicsDB; 57161; -.
DR Antibodypedia; 23629; 176 antibodies from 24 providers.
DR DNASU; 129025; -.
DR Ensembl; ENST00000302097.3; ENSP00000302855.3; ENSG00000169548.3.
DR Ensembl; ENST00000620282.2; ENSP00000480861.1; ENSG00000275499.2.
DR GeneID; 129025; -.
DR KEGG; hsa:129025; -.
DR MANE-Select; ENST00000302097.3; ENSP00000302855.3; NM_080740.5; NP_542778.2.
DR UCSC; uc032qhw.1; human.
DR CTD; 129025; -.
DR DisGeNET; 129025; -.
DR GeneCards; ZNF280A; -.
DR HGNC; HGNC:18597; ZNF280A.
DR HPA; ENSG00000169548; Tissue enriched (adrenal).
DR neXtProt; NX_P59817; -.
DR OpenTargets; ENSG00000169548; -.
DR PharmGKB; PA38358; -.
DR VEuPathDB; HostDB:ENSG00000169548; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165289; -.
DR HOGENOM; CLU_010097_3_2_1; -.
DR InParanoid; P59817; -.
DR OrthoDB; 105829at2759; -.
DR PhylomeDB; P59817; -.
DR TreeFam; TF331707; -.
DR PathwayCommons; P59817; -.
DR SignaLink; P59817; -.
DR BioGRID-ORCS; 129025; 19 hits in 1083 CRISPR screens.
DR ChiTaRS; ZNF280A; human.
DR GenomeRNAi; 129025; -.
DR Pharos; P59817; Tdark.
DR PRO; PR:P59817; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; P59817; protein.
DR Bgee; ENSG00000169548; Expressed in right adrenal gland cortex and 5 other tissues.
DR Genevisible; P59817; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR025243; DUF4195.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF13836; DUF4195; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..542
FT /note="Zinc finger protein 280A"
FT /id="PRO_0000047055"
FT ZN_FING 334..357
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..387
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 423..445
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..474
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 66..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 71
FT /note="N -> K (in dbSNP:rs361959)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028218"
FT VARIANT 136
FT /note="S -> N (in dbSNP:rs362011)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028219"
FT VARIANT 137
FT /note="S -> Y (in dbSNP:rs361580)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028220"
FT VARIANT 246
FT /note="S -> N (in dbSNP:rs362132)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028221"
FT VARIANT 249
FT /note="A -> G (in dbSNP:rs362124)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028222"
FT VARIANT 276
FT /note="L -> F (in dbSNP:rs16989015)"
FT /id="VAR_028223"
FT VARIANT 278
FT /note="D -> N (in dbSNP:rs362003)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028224"
FT VARIANT 486
FT /note="L -> F (in dbSNP:rs361762)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028225"
FT VARIANT 488
FT /note="S -> R (in dbSNP:rs361666)"
FT /evidence="ECO:0000269|PubMed:9074928"
FT /id="VAR_028226"
SQ SEQUENCE 542 AA; 60584 MW; C594222D41A84DCB CRC64;
MGDIFLCKKV ESPKKNLRES KQREEDDEDP DLIYVGVEHV HRDAEVLFVG MISNSKPVVS
NILNRVTPGS NSRRKKGHFR QYPAHVSQPA NHVTSMAKAI MPVSLSEGRS TDSPVTMKSS
SEPGYKMSSP QVVSPSSSDS LPPGTQCLVG AMVSGGGRNE SSPDSKRLST SDINSRDSKR
VKLRDGIPGV PSLAVVPSDM SSTISTNTPS QGICNSSNHV QNGVTFPWPD ANGKAHFNLT
DPERASESAL AMTDISSLAS QNKTFDPKKE NPIVLLSDFY YGQHKGDGQP EQKTHTTFKC
LSCVKVLKNI KFMNHMKHHL EFEKQRNDSW EDHTTCQHCH RQFPTPFQLQ CHIDSVHIAM
GPSAVCKICE LSFETDQVLL QHMKDHHKPG EMPYVCQVCH YRSSVFADVE THFRTCHENT
KNLLCLFCLK LFKTAIPYMN HCWRHSRRRV LQCSKCRLQF LTLKEEIEHK TKDHQTFKKP
EQLQGLPSET KVIIQTSVQP GSSGMASVIV SNTDPQSSPV KTKKKTAMNT RDSRLPCSKD
SS
