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Z286A_HUMAN
ID   Z286A_HUMAN             Reviewed;         521 AA.
AC   Q9HBT8; B4DKF9; Q96JF3;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 186.
DE   RecName: Full=Zinc finger protein 286A;
GN   Name=ZNF286A; Synonyms=KIAA1874, ZNF286;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Romero-Pastrana F., Srivastava A.K.;
RT   "Deletion of a novel zinc finger gene in Smith-Magenis syndrome.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT HIS-90.
RC   TISSUE=Brain;
RX   PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA   Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XX. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 8:85-95(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [5]
RP   SEQUENCE REVISION TO N-TERMINUS.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q9HBT8; Q13895: BYSL; NbExp=3; IntAct=EBI-10754950, EBI-358049;
CC       Q9HBT8; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-10754950, EBI-3866279;
CC       Q9HBT8; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10754950, EBI-10976677;
CC       Q9HBT8; P09067: HOXB5; NbExp=3; IntAct=EBI-10754950, EBI-3893317;
CC       Q9HBT8; P42858: HTT; NbExp=9; IntAct=EBI-10754950, EBI-466029;
CC       Q9HBT8; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10754950, EBI-10172052;
CC       Q9HBT8; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10754950, EBI-79165;
CC       Q9HBT8; Q15287: RNPS1; NbExp=3; IntAct=EBI-10754950, EBI-395959;
CC       Q9HBT8; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10754950, EBI-5235340;
CC       Q9HBT8; A7MD48: SRRM4; NbExp=3; IntAct=EBI-10754950, EBI-3867173;
CC       Q9HBT8; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10754950, EBI-725997;
CC       Q9HBT8; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-10754950, EBI-947459;
CC       Q9HBT8; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10754950, EBI-6427977;
CC       Q9HBT8; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-10754950, EBI-10240849;
CC       Q9HBT8-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-10310244, EBI-10171697;
CC       Q9HBT8-2; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10310244, EBI-10172150;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9HBT8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9HBT8-2; Sequence=VSP_056673;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB47503.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF217226; AAG09701.1; -; mRNA.
DR   EMBL; AB058777; BAB47503.2; ALT_INIT; mRNA.
DR   EMBL; AK296547; BAG59171.1; -; mRNA.
DR   EMBL; AC005324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS11172.1; -. [Q9HBT8-1]
DR   CCDS; CCDS73997.1; -. [Q9HBT8-2]
DR   RefSeq; NP_001124314.1; NM_001130842.1. [Q9HBT8-1]
DR   RefSeq; NP_001275571.1; NM_001288642.1.
DR   RefSeq; NP_001275572.1; NM_001288643.1. [Q9HBT8-2]
DR   RefSeq; NP_001275573.1; NM_001288644.1.
DR   RefSeq; NP_001275574.1; NM_001288645.1.
DR   RefSeq; NP_001275575.1; NM_001288646.1.
DR   RefSeq; NP_001275576.1; NM_001288647.1.
DR   RefSeq; NP_001275577.1; NM_001288648.1.
DR   RefSeq; NP_001275578.1; NM_001288649.1.
DR   RefSeq; NP_065703.1; NM_020652.2. [Q9HBT8-1]
DR   AlphaFoldDB; Q9HBT8; -.
DR   SMR; Q9HBT8; -.
DR   BioGRID; 121489; 34.
DR   IntAct; Q9HBT8; 28.
DR   STRING; 9606.ENSP00000464218; -.
DR   iPTMnet; Q9HBT8; -.
DR   PhosphoSitePlus; Q9HBT8; -.
DR   BioMuta; ZNF286A; -.
DR   DMDM; 20141039; -.
DR   EPD; Q9HBT8; -.
DR   jPOST; Q9HBT8; -.
DR   MassIVE; Q9HBT8; -.
DR   MaxQB; Q9HBT8; -.
DR   PaxDb; Q9HBT8; -.
DR   PeptideAtlas; Q9HBT8; -.
DR   PRIDE; Q9HBT8; -.
DR   ProteomicsDB; 81592; -. [Q9HBT8-1]
DR   Antibodypedia; 13162; 239 antibodies from 19 providers.
DR   DNASU; 57335; -.
DR   Ensembl; ENST00000421016.5; ENSP00000397163.1; ENSG00000187607.16. [Q9HBT8-1]
DR   Ensembl; ENST00000464847.6; ENSP00000464218.1; ENSG00000187607.16. [Q9HBT8-1]
DR   Ensembl; ENST00000583566.6; ENSP00000464063.1; ENSG00000187607.16. [Q9HBT8-1]
DR   Ensembl; ENST00000593105.5; ENSP00000466154.1; ENSG00000187607.16. [Q9HBT8-2]
DR   GeneID; 57335; -.
DR   KEGG; hsa:57335; -.
DR   MANE-Select; ENST00000583566.6; ENSP00000464063.1; NM_001130842.2; NP_001124314.1.
DR   UCSC; uc002gpa.4; human. [Q9HBT8-1]
DR   CTD; 57335; -.
DR   GeneCards; ZNF286A; -.
DR   HGNC; HGNC:13501; ZNF286A.
DR   HPA; ENSG00000187607; Low tissue specificity.
DR   neXtProt; NX_Q9HBT8; -.
DR   OpenTargets; ENSG00000187607; -.
DR   PharmGKB; PA162410066; -.
DR   VEuPathDB; HostDB:ENSG00000187607; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161686; -.
DR   HOGENOM; CLU_002678_44_3_1; -.
DR   InParanoid; Q9HBT8; -.
DR   OMA; MKKQRTC; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q9HBT8; -.
DR   PathwayCommons; Q9HBT8; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q9HBT8; -.
DR   BioGRID-ORCS; 57335; 10 hits in 1092 CRISPR screens.
DR   ChiTaRS; ZNF286A; human.
DR   GenomeRNAi; 57335; -.
DR   Pharos; Q9HBT8; Tdark.
DR   PRO; PR:Q9HBT8; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9HBT8; protein.
DR   Bgee; ENSG00000187607; Expressed in ganglionic eminence and 134 other tissues.
DR   ExpressionAtlas; Q9HBT8; baseline and differential.
DR   Genevisible; Q9HBT8; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 6.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..521
FT                   /note="Zinc finger protein 286A"
FT                   /id="PRO_0000047510"
FT   DOMAIN          45..111
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         243..265
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         271..293
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         298..320
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         326..348
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         354..376
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         382..404
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         410..432
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         438..460
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         466..488
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         494..516
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         1..11
FT                   /note="METDLAEMPEK -> M (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056673"
FT   VARIANT         90
FT                   /note="Y -> H (in dbSNP:rs3760299)"
FT                   /evidence="ECO:0000269|PubMed:11347906"
FT                   /id="VAR_021892"
SQ   SEQUENCE   521 AA;  60175 MW;  485C3FF3DD210DBB CRC64;
     METDLAEMPE KGALSSQDSP HFQEKSTEEG EVAALRLTAR SQETVTFKDV AMDFTPEEWG
     KLDPAQRDVM LENYRNLVSL WLPVSKPESY NLENGKEPLK LERKAPKSSY SDMETRPQSK
     DSTSVQDFSK AESCKVAIID RLTRNSVYDS NLEAALECEN WLENQQGNQE RHLREMFTHM
     NSLSEETDHK HDVYWKSFNQ KSVLITEDRV PKGSYAFHTL EKSLKQKSNL MKKQRTYKEK
     KPHKCNDCGE LFTYHSVLIR HQRVHTGEKP YTCNECGKSF SHRANLTKHQ RTHTRILFEC
     SECKKTFTES SSLATHQRIH VGERPYECNE CGKGFNRSTH LVQHQLIHTG VKPYECNECD
     KAFIHSSALI KHQRTHTGEK PYKCQECGKA FSHCSSLTKH QRVHTGEKPY ECSECGKTFS
     QSTHLVQHQR IHTGEKPYEC NECGKTFSRS SNFAKHQRIH IGKKPYKCSE CGKAFIHSSA
     LIQHQRTHTG EKPFRCNECG KSFKCSSSLI RHQRVHTEEQ P
 
 
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