Z286B_HUMAN
ID Z286B_HUMAN Reviewed; 522 AA.
AC P0CG31;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Putative zinc finger protein 286B;
GN Name=ZNF286B; Synonyms=ZNF286C, ZNF286L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC026271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001138517.1; NM_001145045.1.
DR AlphaFoldDB; P0CG31; -.
DR SMR; P0CG31; -.
DR STRING; 9606.ENSP00000461413; -.
DR iPTMnet; P0CG31; -.
DR PhosphoSitePlus; P0CG31; -.
DR BioMuta; ZNF286B; -.
DR DMDM; 300681206; -.
DR jPOST; P0CG31; -.
DR MassIVE; P0CG31; -.
DR MaxQB; P0CG31; -.
DR PaxDb; P0CG31; -.
DR PeptideAtlas; P0CG31; -.
DR PRIDE; P0CG31; -.
DR ProteomicsDB; 52461; -.
DR UCSC; uc010vyd.3; human.
DR GeneCards; ZNF286B; -.
DR HGNC; HGNC:33241; ZNF286B.
DR neXtProt; NX_P0CG31; -.
DR PharmGKB; PA162410081; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_0_16_1; -.
DR InParanoid; P0CG31; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P0CG31; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; P0CG31; -.
DR BioGRID-ORCS; 729288; 15 hits in 995 CRISPR screens.
DR ChiTaRS; ZNF286B; human.
DR GenomeRNAi; 729288; -.
DR Pharos; P0CG31; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0CG31; protein.
DR Genevisible; P0CG31; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..522
FT /note="Putative zinc finger protein 286B"
FT /id="PRO_0000395360"
FT ZN_FING 244..266
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 272..294
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 495..517
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 59572 MW; D1818B9F64EE43D1 CRC64;
METDLAEMPE KGVLSSQDSP HFQEKSTEEG EVAALRLTAR SQAAAAAAAP GSRSLRGVHV
PPPLHPAPAR EEIKSTCSLK ACFSLSLTLT YYRTAFLLST ENEGNLHFQC PSDVETRPQS
KDSTSVQDFS KAESCKVAII DRLTRNSVYD SNLEAALECE NWLEKQQGNQ ERHLREMFTH
MNSLSEETDH EHDVYWKSFN QKSVLITEDR VPKGSYAFHT LEKSLKQKSN LMKKQRTYKE
KKPHKCNDCG ELFTCHSVHI QHQRVHTGEK PYTCNECGKS FSHRANLTKH QRTHTRILFE
CRECKKTFTE SSSLATHQRI HVGERPYECN ECGKGFNRST HLVQHQLIHT GVRPYECNEC
DKAFIHSSAL IKHQRTHTGE KPYKCQECGK AFSHCSSLTK HQRVHTGEKP YECSECGKTF
SQSTHLVQHQ RIHTGEKPYE CSECGKTFSQ SSNFAKHQRI HIGKKPYKCS ECGKAFIHSS
ALIQHQRTHT GEKPFRCNEC GKSFKCSSSL IRHQRVHTEE QP
