Z324A_HUMAN
ID Z324A_HUMAN Reviewed; 553 AA.
AC O75467; B3KRX1;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 324A;
DE AltName: Full=Zinc finger protein ZF5128;
GN Name=ZNF324; Synonyms=ZNF324A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11779640; DOI=10.1016/s0167-4781(01)00337-2;
RA Rue S.W., Kim B.W., Jun D.Y., Kim Y.H.;
RT "Nucleotide sequence and cell cycle-associated differential expression of
RT ZF5128, a novel Kruppel type zinc finger protein gene.";
RL Biochim. Biophys. Acta 1522:230-237(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation. May be
CC involved in regulation of cell proliferation.
CC {ECO:0000305|PubMed:11779640}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in the spleen, thymus, and
CC PBMC, at low levels in the prostate, ovary, small intestine, colon
CC (mucosal lining), placenta, lung, and pancreas, and very weakly
CC expressed in the liver and kidney. {ECO:0000269|PubMed:11779640}.
CC -!- INDUCTION: Induced at the early stage of T cell activation. Regulated
CC at the transcriptional level during the cell cycle. Induced at a
CC maximum level in the S phase. {ECO:0000269|PubMed:11779640}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF060503; AAC33716.1; -; mRNA.
DR EMBL; AK092341; BAG52533.1; -; mRNA.
DR EMBL; CH471135; EAW72594.1; -; Genomic_DNA.
DR CCDS; CCDS12981.1; -.
DR RefSeq; NP_055162.1; NM_014347.2.
DR AlphaFoldDB; O75467; -.
DR SMR; O75467; -.
DR BioGRID; 117331; 43.
DR IntAct; O75467; 20.
DR STRING; 9606.ENSP00000444812; -.
DR iPTMnet; O75467; -.
DR PhosphoSitePlus; O75467; -.
DR BioMuta; ZNF324; -.
DR EPD; O75467; -.
DR jPOST; O75467; -.
DR MassIVE; O75467; -.
DR MaxQB; O75467; -.
DR PaxDb; O75467; -.
DR PeptideAtlas; O75467; -.
DR PRIDE; O75467; -.
DR ProteomicsDB; 50026; -.
DR Antibodypedia; 33347; 126 antibodies from 19 providers.
DR DNASU; 25799; -.
DR Ensembl; ENST00000196482.4; ENSP00000196482.3; ENSG00000083812.13.
DR Ensembl; ENST00000536459.6; ENSP00000444812.1; ENSG00000083812.13.
DR GeneID; 25799; -.
DR KEGG; hsa:25799; -.
DR MANE-Select; ENST00000196482.4; ENSP00000196482.3; NM_014347.3; NP_055162.1.
DR UCSC; uc002qsw.3; human.
DR CTD; 25799; -.
DR GeneCards; ZNF324; -.
DR HGNC; HGNC:14096; ZNF324.
DR HPA; ENSG00000083812; Low tissue specificity.
DR MIM; 617477; gene.
DR neXtProt; NX_O75467; -.
DR OpenTargets; ENSG00000083812; -.
DR PharmGKB; PA37839; -.
DR VEuPathDB; HostDB:ENSG00000083812; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163047; -.
DR InParanoid; O75467; -.
DR OMA; RTFRERP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; O75467; -.
DR TreeFam; TF337574; -.
DR PathwayCommons; O75467; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; O75467; -.
DR BioGRID-ORCS; 25799; 20 hits in 1102 CRISPR screens.
DR GenomeRNAi; 25799; -.
DR Pharos; O75467; Tdark.
DR PRO; PR:O75467; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O75467; protein.
DR Bgee; ENSG00000083812; Expressed in cortical plate and 99 other tissues.
DR ExpressionAtlas; O75467; baseline and differential.
DR Genevisible; O75467; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IEP:UniProtKB.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..553
FT /note="Zinc finger protein 324A"
FT /id="PRO_0000047533"
FT DOMAIN 1..72
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 257..279
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 186..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 130..135
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000305|PubMed:11779640"
SQ SEQUENCE 553 AA; 61104 MW; BBCB5C469A13108F CRC64;
MAFEDVAVYF SQEEWGLLDT AQRALYRRVM LDNFALVASL GLSTSRPRVV IQLERGEEPW
VPSGTDTTLS RTTYRRRNPG SWSLTEDRDV SGEWPRAFPD TPPGMTTSVF PVAGACHSVK
SLQRQRGASP SRERKPTGVS VIYWERLLLG SGSGQASVSL RLTSPLRPPE GVRLREKTLT
EHALLGRQPR TPERQKPCAQ EVPGRTFGSA QDLEAAGGRG HHRMGAVWQE PHRLLGGQEP
STWDELGEAL HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECAQC GKAFSQTSHL
TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF SHGSNLSQHR
KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA LCGAAFSQGS SLFKHQRVHT
GEKPFACPQC GRAFSHSSNL TQHQLLHTGE RPFRCVDCGK AFAKGAVLLS HRRIHTGEKP
FVCTQCGRAF RERPALFHHQ RIHTGEKTVR RSRASLHPQA RSVAGASSEG APAKETEPTP
ASGPAAVSQP AEV
