Z354A_MOUSE
ID Z354A_MOUSE Reviewed; 572 AA.
AC Q61751; Q9QXU0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Zinc finger protein 354A;
DE AltName: Full=Kidney, ischemia, and developmentally-regulated protein 1;
DE AltName: Full=Renal transcription factor Kid-1;
DE AltName: Full=Transcription factor 17;
DE Short=TCF-17;
GN Name=Znf354a; Synonyms=Kid1, Tcf17, Zfp354a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens;
RX PubMed=9176064; DOI=10.1006/exer.1996.0206;
RA Brady J.P., Duncan M.K., Wawrousek E.F., Piatigorsky J.;
RT "The transcription factor, Kid-1, is highly expressed in both eye and
RT kidney of the mouse.";
RL Exp. Eye Res. 64:287-290(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/Sv;
RX PubMed=10564808; DOI=10.1016/s0378-1119(99)00440-0;
RA Tekki-Kessaris N., Bonventre J.V., Boulter C.A.;
RT "Characterization of the mouse Kid1 gene and identification of a highly
RT related gene, Kid2.";
RL Gene 240:13-22(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: It may play a role in renal development and may also be
CC involved in the repair of the kidney after ischemia-reperfusion or
CC folic acid administration.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Highly expressed in eye and kidney. Detected at
CC high levels in adult brain and kidney, and at lower levels in adult
CC liver, lung, skeletal muscle, heart, salivary gland, testis and tongue.
CC Detected in embryonic brain, heart, lung,kidney and gut.
CC {ECO:0000269|PubMed:10564808}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L77247; AAA96309.1; -; mRNA.
DR EMBL; AF184111; AAF01033.1; -; mRNA.
DR EMBL; AL645962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466575; EDL33680.1; -; Genomic_DNA.
DR EMBL; BC050843; AAH50843.1; -; mRNA.
DR CCDS; CCDS24648.1; -.
DR RefSeq; NP_001313495.1; NM_001326566.1.
DR RefSeq; NP_033355.2; NM_009329.4.
DR RefSeq; XP_006532853.1; XM_006532790.1.
DR AlphaFoldDB; Q61751; -.
DR SMR; Q61751; -.
DR BioGRID; 204002; 3.
DR IntAct; Q61751; 2.
DR STRING; 10090.ENSMUSP00000104747; -.
DR iPTMnet; Q61751; -.
DR PhosphoSitePlus; Q61751; -.
DR jPOST; Q61751; -.
DR PaxDb; Q61751; -.
DR PRIDE; Q61751; -.
DR Antibodypedia; 17609; 61 antibodies from 23 providers.
DR DNASU; 21408; -.
DR Ensembl; ENSMUST00000020628; ENSMUSP00000020628; ENSMUSG00000020364.
DR Ensembl; ENSMUST00000102766; ENSMUSP00000099827; ENSMUSG00000020364.
DR GeneID; 21408; -.
DR KEGG; mmu:21408; -.
DR UCSC; uc007itl.1; mouse.
DR CTD; 21408; -.
DR MGI; MGI:103172; Zfp354a.
DR VEuPathDB; HostDB:ENSMUSG00000020364; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161487; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q61751; -.
DR OMA; TNHYKTH; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 21408; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Pim3; mouse.
DR PRO; PR:Q61751; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q61751; protein.
DR Bgee; ENSMUSG00000020364; Expressed in embryonic post-anal tail and 151 other tissues.
DR ExpressionAtlas; Q61751; baseline and differential.
DR Genevisible; Q61751; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0007000; P:nucleolus organization; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Isopeptide bond;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..572
FT /note="Zinc finger protein 354A"
FT /id="PRO_0000047239"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 184..206
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..399
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 405..427
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..455
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..483
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 489..511
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 517..539
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 545..567
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 121
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O60765"
FT CROSSLNK 155
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O60765"
FT CROSSLNK 238
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O60765"
FT CONFLICT 82
FT /note="G -> D (in Ref. 1; AAA96309)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 572 AA; 65662 MW; 1BB5DDFAA51AA9B3 CRC64;
MAPEQWEATS QVSLTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL ASLGFPFTKP
KVISLLQQGE DPWKVEEEGP GGFSLGLKCS QRTTKSTQTQ DSSFRELIMR KSKRKEPWNM
KSENLSIHEG KLEEKWDVNA STIERSYKSN ELSPKSHREK RSSECEKQIS YLSNPLGITP
DKRYKCSMCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA FSQSSALIQH QITHTGEKPY
VCKECGKAFT LSTSLYKHLR THTVEKSYRC KECGKSFGRR SGLFIHQKVH AGENPYKYNP
GRKASTSLSG CQRIHSRKKT YLCNECGNTF KSSSSLRYHQ RIHTGEKPFK CSECGRAFSQ
SASLIQHERI HTGEKPYRCS ECGKGFTSIS RLNRHRIIHT GEKFYNCNEC GKALSSHSTL
IIHERIHTGE KPCKCKVCGK AFRQSSALIQ HQRMHTGERP YKCNECGKTF RCNSSLSNHQ
RTHTGEKPYR CQECGMSFGQ SSALIQHRRI HTGEKPFKCN TCGKTFRQSS SRIAHQRIHT
GEKPYECNTC GKLFNHRSSL TNHYKIHVDE DP
