Z354A_RAT
ID Z354A_RAT Reviewed; 576 AA.
AC Q02975;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Zinc finger protein 354A;
DE AltName: Full=Kidney, ischemia, and developmentally-regulated protein 1;
DE AltName: Full=Renal transcription factor Kid-1;
DE AltName: Full=Transcription factor 17;
DE Short=TCF-17;
GN Name=Znf354a; Synonyms=Kid1, Tcf17, Zfp354a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=8382778; DOI=10.1128/mcb.13.3.1933-1942.1993;
RA Witzgall R., O'Leary E., Gessner R., Ouellette A.J., Bonventre J.V.;
RT "Kid-1, a putative renal transcription factor: regulation during ontogeny
RT and in response to ischemia and toxic injury.";
RL Mol. Cell. Biol. 13:1933-1942(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-110.
RC TISSUE=Liver;
RX PubMed=8020966; DOI=10.1006/geno.1994.1154;
RA Witzgall R., Volk R., Yeung R.S., Bonventre J.V.;
RT "Genomic structure and chromosomal location of the rat gene encoding the
RT zinc finger transcription factor Kid-1.";
RL Genomics 20:203-209(1994).
CC -!- FUNCTION: It may play a role in renal development and may also be
CC involved in the repair of the kidney after ischemia-reperfusion or
CC folic acid administration.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Predominantly in the kidney.
CC -!- DEVELOPMENTAL STAGE: Protein levels accumulate with age in postnatal
CC renal development.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; M96548; AAB07673.1; -; mRNA.
DR EMBL; S73488; AAB31189.1; -; Genomic_DNA.
DR EMBL; S73484; AAB31189.1; JOINED; Genomic_DNA.
DR EMBL; S73485; AAB31189.1; JOINED; Genomic_DNA.
DR EMBL; S73486; AAB31189.1; JOINED; Genomic_DNA.
DR PIR; A48157; A48157.
DR RefSeq; NP_434685.1; NM_052798.2.
DR RefSeq; XP_006246289.1; XM_006246227.3.
DR AlphaFoldDB; Q02975; -.
DR SMR; Q02975; -.
DR IntAct; Q02975; 1.
DR STRING; 10116.ENSRNOP00000049437; -.
DR iPTMnet; Q02975; -.
DR PhosphoSitePlus; Q02975; -.
DR PaxDb; Q02975; -.
DR GeneID; 24522; -.
DR KEGG; rno:24522; -.
DR UCSC; RGD:2967; rat.
DR CTD; 21408; -.
DR RGD; 2967; Zfp354a.
DR VEuPathDB; HostDB:ENSRNOG00000003634; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q02975; -.
DR OMA; TNHYKTH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q02975; -.
DR TreeFam; TF341817; -.
DR Reactome; R-RNO-212436; Generic Transcription Pathway.
DR PRO; PR:Q02975; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000003634; Expressed in adult mammalian kidney and 19 other tissues.
DR ExpressionAtlas; Q02975; baseline and differential.
DR Genevisible; Q02975; RN.
DR GO; GO:0005730; C:nucleolus; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001822; P:kidney development; IEP:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:RGD.
DR GO; GO:0007000; P:nucleolus organization; IMP:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0051593; P:response to folic acid; IEP:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Isopeptide bond;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..576
FT /note="Zinc finger protein 354A"
FT /id="PRO_0000047240"
FT DOMAIN 14..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 188..210
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 216..238
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 244..266
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 272..294
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOTIF 170..189
FT /note="Nuclear localization signal"
FT CROSSLNK 125
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O60765"
FT CROSSLNK 159
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O60765"
FT CROSSLNK 242
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O60765"
SQ SEQUENCE 576 AA; 66253 MW; 61C2C43156BDD63A CRC64;
MAPEQREGAS QVSVTFEDVA VLFTRDEWKK LDLSQRSLYR EVMLENYSNL ASMAGFLFTK
PKVISLLQQG EDPWQVEKEG PRYFSLGLKC SHRTTKSTQT QDSSFQELIV RKSKRTFAFE
PLNMKSENLF IHEGKLEEKW DKNTLTVERS HKNNEFSPKS HREKRSSECK KQISYLSNPP
GITPDKRYKC SMCEKTFINT SSLRKHEKNH SGEKLFKCKE CSKAFSQSSA LIQHQITHTG
EKPYVCKECG KAFTLSTSLY KHLRTHTVEK SYRCKECGKS FGQRSGLFIH QKIHARENPH
RYNPGRKASA SLSGCQRAHS RKKTYLCNEC GNTFKSSSSL RYHQRIHTGE KPFRCSECGR
AFSQSASLIQ HERIHTGEKP YRCGECGKGF TSISRLNRHR IIHTGEKLYN CNECGKALSS
HSTLIIHERI HTGEKPCKCK VCGKAFRQSS ALIQHQRMHT GERPYKCNEC GKTFRCNSSL
SNHQRIHTGE KPYQCIECGM SFGQSSALIQ HRRIHTGEKP FKCNTCGKTF RQSSSRIAHQ
RIHTGEKPYE CNTCGKLFNY RSSLTNHYKI HVDEDP
