Z355P_HUMAN
ID Z355P_HUMAN Reviewed; 428 AA.
AC Q9NSJ1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Putative zinc finger protein 355P;
DE AltName: Full=Zinc finger protein ZnFP01;
GN Name=ZNF355P; Synonyms=ZNF834; ORFNames=PRED65;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-83.
RX PubMed=1740334; DOI=10.1016/0888-7543(92)90372-y;
RA Hoovers J.M.N., Mannens M., John R., Bliek J., van Heyningen V.,
RA Porteous D.J., Leschot N.J., Westerveld A., Little P.F.R.;
RT "High-resolution localization of 69 potential human zinc finger protein
RT genes: a number are clustered.";
RL Genomics 12:254-263(1992).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB90395.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163202; CAB90395.1; ALT_SEQ; Genomic_DNA.
DR PIR; A42075; A42075.
DR AlphaFoldDB; Q9NSJ1; -.
DR SMR; Q9NSJ1; -.
DR iPTMnet; Q9NSJ1; -.
DR PhosphoSitePlus; Q9NSJ1; -.
DR BioMuta; HGNC:17218; -.
DR DMDM; 187671925; -.
DR jPOST; Q9NSJ1; -.
DR MassIVE; Q9NSJ1; -.
DR PeptideAtlas; Q9NSJ1; -.
DR PRIDE; Q9NSJ1; -.
DR ProteomicsDB; 82561; -.
DR GeneCards; ZNF355P; -.
DR HGNC; HGNC:17218; ZNF355P.
DR neXtProt; NX_Q9NSJ1; -.
DR InParanoid; Q9NSJ1; -.
DR PhylomeDB; Q9NSJ1; -.
DR Pharos; Q9NSJ1; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9NSJ1; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..428
FT /note="Putative zinc finger protein 355P"
FT /id="PRO_0000332124"
FT DOMAIN 1..64
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 72..94
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 100..122
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 128..150
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 156..178
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 7; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 428 AA; 49689 MW; D30694E8CB6B36E6 CRC64;
MRDEVAEKEK ADINVTLVFQ GYENTPIMVC VDGIVFSKPD LVTCLEQRKK PWSMKHPGLT
QHNIVHTGDK PYKCKDCGKI FKWSSNLTIH QRIHSGEKPY KCEECGKAFK QSSKLNEHMR
AHTGEKFYKC EECGKAFKHP SGLTLHKRIH TGENPYKFEE CDKAFYWVLS FTKHMIIHRG
EKPYKYQECG KAFKWSSNLT IHKRIHTGEK PCKCEECGKA CKQSLGLTIQ KRIHTEEKPY
KCEECGSSNL TIYKKIHAGE KPYNCEKCGK AFYCSSNLIQ NNIVHAEEKH YKCQECGKAF
KKSLDLNVHK IIHSGEKPYR YEECGKITHS GEESYKCEEC GKGFYCSSSL TKHMIVHTEE
KLYKCEECGK AFKWSSELTI HQRIRTEEKP YKCEECVRVF KHSSKLNEHK RNHTGEKPYK
CEACGKAF
