CC124_HUMAN
ID CC124_HUMAN Reviewed; 223 AA.
AC Q96CT7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Coiled-coil domain-containing protein 124;
GN Name=CCDC124;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-194, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RASGEF1B, TISSUE
RP SPECIFICITY, AND PHOSPHORYLATION AT SER-141.
RX PubMed=23894443; DOI=10.1371/journal.pone.0069289;
RA Telkoparan P., Erkek S., Yaman E., Alotaibi H., Bayik D., Tazebay U.H.;
RT "Coiled-coil domain containing protein 124 is a novel centrosome and
RT midbody protein that interacts with the ras-guanine nucleotide exchange
RT factor 1B and is involved in cytokinesis.";
RL PLoS ONE 8:E69289-E69289(2013).
CC -!- FUNCTION: Required for proper progression of late cytokinetic stages.
CC {ECO:0000269|PubMed:23894443}.
CC -!- SUBUNIT: Interacts with RASGEF1B. {ECO:0000269|PubMed:23894443}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:23894443}. Midbody
CC {ECO:0000269|PubMed:23894443}. Note=Colocalizes with gamma-tubulin at
CC interphase, prophase, metaphase, and anaphase. Relocates from
CC centrosome to midbody at telophase.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:23894443}.
CC -!- SIMILARITY: Belongs to the CCDC124 family. {ECO:0000305}.
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DR EMBL; BC013949; AAH13949.1; -; mRNA.
DR CCDS; CCDS12369.1; -.
DR RefSeq; NP_001129675.1; NM_001136203.1.
DR RefSeq; NP_612451.1; NM_138442.3.
DR PDB; 6Z6L; EM; 3.00 A; CE=1-223.
DR PDB; 6ZM7; EM; 2.70 A; CE=1-223.
DR PDB; 6ZME; EM; 3.00 A; CE=1-223.
DR PDBsum; 6Z6L; -.
DR PDBsum; 6ZM7; -.
DR PDBsum; 6ZME; -.
DR AlphaFoldDB; Q96CT7; -.
DR SMR; Q96CT7; -.
DR BioGRID; 125411; 61.
DR IntAct; Q96CT7; 37.
DR MINT; Q96CT7; -.
DR STRING; 9606.ENSP00000471455; -.
DR iPTMnet; Q96CT7; -.
DR PhosphoSitePlus; Q96CT7; -.
DR BioMuta; CCDC124; -.
DR DMDM; 74731379; -.
DR EPD; Q96CT7; -.
DR jPOST; Q96CT7; -.
DR MassIVE; Q96CT7; -.
DR MaxQB; Q96CT7; -.
DR PaxDb; Q96CT7; -.
DR PeptideAtlas; Q96CT7; -.
DR PRIDE; Q96CT7; -.
DR ProteomicsDB; 76221; -.
DR Antibodypedia; 27882; 86 antibodies from 16 providers.
DR DNASU; 115098; -.
DR Ensembl; ENST00000445755.7; ENSP00000408730.1; ENSG00000007080.11.
DR Ensembl; ENST00000597436.5; ENSP00000471455.1; ENSG00000007080.11.
DR GeneID; 115098; -.
DR KEGG; hsa:115098; -.
DR MANE-Select; ENST00000445755.7; ENSP00000408730.1; NM_001136203.2; NP_001129675.1.
DR UCSC; uc002nhs.4; human.
DR CTD; 115098; -.
DR GeneCards; CCDC124; -.
DR HGNC; HGNC:25171; CCDC124.
DR HPA; ENSG00000007080; Low tissue specificity.
DR neXtProt; NX_Q96CT7; -.
DR OpenTargets; ENSG00000007080; -.
DR PharmGKB; PA147358292; -.
DR VEuPathDB; HostDB:ENSG00000007080; -.
DR eggNOG; KOG3223; Eukaryota.
DR GeneTree; ENSGT00390000012482; -.
DR HOGENOM; CLU_069723_0_1_1; -.
DR InParanoid; Q96CT7; -.
DR OMA; RHPEKRM; -.
DR OrthoDB; 1585903at2759; -.
DR PhylomeDB; Q96CT7; -.
DR TreeFam; TF105913; -.
DR PathwayCommons; Q96CT7; -.
DR SignaLink; Q96CT7; -.
DR BioGRID-ORCS; 115098; 17 hits in 1081 CRISPR screens.
DR ChiTaRS; CCDC124; human.
DR GenomeRNAi; 115098; -.
DR Pharos; Q96CT7; Tdark.
DR PRO; PR:Q96CT7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96CT7; protein.
DR Bgee; ENSG00000007080; Expressed in cingulate cortex and 146 other tissues.
DR ExpressionAtlas; Q96CT7; baseline and differential.
DR Genevisible; Q96CT7; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR010422; Ccdc124/Oxs1.
DR PANTHER; PTHR21680; PTHR21680; 1.
DR Pfam; PF06244; Ccdc124; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..223
FT /note="Coiled-coil domain-containing protein 124"
FT /id="PRO_0000263735"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..82
FT /evidence="ECO:0000255"
FT COMPBIAS 14..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 141
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:23894443,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 138
FT /note="E -> Q (in dbSNP:rs8104153)"
FT /id="VAR_053809"
SQ SEQUENCE 223 AA; 25835 MW; DFC65D526057DE27 CRC64;
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE QRKEEKEKRR
LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI EDTLRRDHQL REAPDTAEKA
KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ
LPRLKQENPN MRLSQLKQLL KKEWLRSPDN PMNQRAVPFN APK
