Z385B_HUMAN
ID Z385B_HUMAN Reviewed; 471 AA.
AC Q569K4; Q49A04; Q6ZMZ7; Q8IY01; Q8N8H2; Q96DK4;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Zinc finger protein 385B;
DE AltName: Full=Zinc finger protein 533;
GN Name=ZNF385B; Synonyms=ZNF533;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5).
RC TISSUE=Gastric mucosa, Prostate, and Synovial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION IN APOPTOSIS, SUBCELLULAR LOCATION, INTERACTION WITH TP53, AND
RP TISSUE SPECIFICITY.
RX PubMed=22945289; DOI=10.1002/eji.201242530;
RA Iijima K., Yamada H., Miharu M., Imadome K., Miyagawa Y., Akimoto S.,
RA Kobayashi K., Okita H., Nakazawa A., Fujiwara S., Fujimoto J., Kiyokawa N.;
RT "ZNF385B is characteristically expressed in germinal center B cells and
RT involved in B-cell apoptosis.";
RL Eur. J. Immunol. 42:3405-3415(2012).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [5]
RP VARIANT TYR-416.
RX PubMed=26755636; DOI=10.1101/gr.199430.115;
RA Spielmann M., Kakar N., Tayebi N., Leettola C., Nuernberg G., Sowada N.,
RA Lupianez D.G., Harabula I., Floettmann R., Horn D., Chan W.L., Wittler L.,
RA Yilmaz R., Altmueller J., Thiele H., van Bokhoven H., Schwartz C.E.,
RA Nuernberg P., Bowie J.U., Ahmad J., Kubisch C., Mundlos S., Borck G.;
RT "Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK
RT as a cause of limb defects in humans and mice.";
RL Genome Res. 26:183-191(2016).
CC -!- FUNCTION: May play a role in p53/TP53-mediated apoptosis.
CC {ECO:0000269|PubMed:22945289}.
CC -!- SUBUNIT: Interacts with p53/TP53; the interaction is direct.
CC {ECO:0000269|PubMed:22945289}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22945289}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=IF-1;
CC IsoId=Q569K4-1; Sequence=Displayed;
CC Name=2; Synonyms=IF-2;
CC IsoId=Q569K4-2; Sequence=VSP_015974, VSP_015976;
CC Name=3; Synonyms=IF-3;
CC IsoId=Q569K4-3; Sequence=VSP_015973;
CC Name=4;
CC IsoId=Q569K4-4; Sequence=VSP_015972, VSP_015977, VSP_015978;
CC Name=5;
CC IsoId=Q569K4-5; Sequence=VSP_015975, VSP_015979, VSP_015980;
CC -!- TISSUE SPECIFICITY: Detected in germinal center of lymph node (at
CC protein level). Expressed in spleen, lymph node and tonsil.
CC {ECO:0000269|PubMed:22945289}.
CC -!- MISCELLANEOUS: [Isoform 2]: Major isoform in tonsil. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Major isoform in lymph node. {ECO:0000305}.
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DR EMBL; AK057999; BAB71629.1; -; mRNA.
DR EMBL; AK096822; BAC04870.1; -; mRNA.
DR EMBL; AK131432; BAD18578.1; -; mRNA.
DR EMBL; BC038422; AAH38422.1; -; mRNA.
DR EMBL; BC048123; AAH48123.1; -; mRNA.
DR EMBL; BC092423; AAH92423.1; -; mRNA.
DR CCDS; CCDS46463.1; -. [Q569K4-2]
DR CCDS; CCDS46464.1; -. [Q569K4-3]
DR RefSeq; NP_001106868.1; NM_001113397.1. [Q569K4-2]
DR RefSeq; NP_001106869.1; NM_001113398.1. [Q569K4-3]
DR RefSeq; NP_001269654.1; NM_001282725.1. [Q569K4-3]
DR RefSeq; NP_689733.3; NM_152520.4.
DR RefSeq; XP_016858927.1; XM_017003438.1.
DR RefSeq; XP_016858928.1; XM_017003439.1.
DR AlphaFoldDB; Q569K4; -.
DR BioGRID; 127344; 4.
DR IntAct; Q569K4; 1.
DR STRING; 9606.ENSP00000386845; -.
DR iPTMnet; Q569K4; -.
DR PhosphoSitePlus; Q569K4; -.
DR BioMuta; ZNF385B; -.
DR DMDM; 74741028; -.
DR jPOST; Q569K4; -.
DR MassIVE; Q569K4; -.
DR PaxDb; Q569K4; -.
DR PeptideAtlas; Q569K4; -.
DR PRIDE; Q569K4; -.
DR ProteomicsDB; 62574; -. [Q569K4-1]
DR ProteomicsDB; 62575; -. [Q569K4-2]
DR ProteomicsDB; 62576; -. [Q569K4-3]
DR ProteomicsDB; 62577; -. [Q569K4-4]
DR ProteomicsDB; 62578; -. [Q569K4-5]
DR Antibodypedia; 33976; 233 antibodies from 16 providers.
DR DNASU; 151126; -.
DR Ensembl; ENST00000336917.9; ENSP00000338225.5; ENSG00000144331.20. [Q569K4-3]
DR Ensembl; ENST00000409343.5; ENSP00000386379.1; ENSG00000144331.20. [Q569K4-2]
DR Ensembl; ENST00000409692.5; ENSP00000386507.1; ENSG00000144331.20. [Q569K4-3]
DR GeneID; 151126; -.
DR KEGG; hsa:151126; -.
DR UCSC; uc002unj.4; human. [Q569K4-1]
DR CTD; 151126; -.
DR DisGeNET; 151126; -.
DR GeneCards; ZNF385B; -.
DR HGNC; HGNC:26332; ZNF385B.
DR HPA; ENSG00000144331; Tissue enhanced (retina).
DR MIM; 612344; gene.
DR neXtProt; NX_Q569K4; -.
DR OpenTargets; ENSG00000144331; -.
DR PharmGKB; PA162410114; -.
DR VEuPathDB; HostDB:ENSG00000144331; -.
DR eggNOG; ENOG502QS7G; Eukaryota.
DR GeneTree; ENSGT00940000155611; -.
DR HOGENOM; CLU_027876_0_0_1; -.
DR InParanoid; Q569K4; -.
DR OMA; GSRMKVQ; -.
DR OrthoDB; 899600at2759; -.
DR PhylomeDB; Q569K4; -.
DR TreeFam; TF326622; -.
DR PathwayCommons; Q569K4; -.
DR SignaLink; Q569K4; -.
DR BioGRID-ORCS; 151126; 12 hits in 1071 CRISPR screens.
DR ChiTaRS; ZNF385B; human.
DR GenomeRNAi; 151126; -.
DR Pharos; Q569K4; Tbio.
DR PRO; PR:Q569K4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q569K4; protein.
DR Bgee; ENSG00000144331; Expressed in cardiac muscle of right atrium and 156 other tissues.
DR ExpressionAtlas; Q569K4; baseline and differential.
DR Genevisible; Q569K4; HS.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0002039; F:p53 binding; IPI:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IDA:UniProtKB.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 4.
DR SUPFAM; SSF57667; SSF57667; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..471
FT /note="Zinc finger protein 385B"
FT /id="PRO_0000191812"
FT ZN_FING 34..64
FT /note="Matrin-type 1"
FT ZN_FING 157..187
FT /note="Matrin-type 2"
FT ZN_FING 282..316
FT /note="Matrin-type 3"
FT ZN_FING 348..378
FT /note="Matrin-type 4"
FT REGION 1..93
FT /note="Required for induction of apoptosis"
FT REGION 50..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..471
FT /note="Interaction with p53/TP53"
FT /evidence="ECO:0000269|PubMed:22945289"
FT REGION 175..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..196
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_015972"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_015973"
FT VAR_SEQ 1..76
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015974"
FT VAR_SEQ 1
FT /note="M -> MRYSLSPDNHLEDGIM (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015975"
FT VAR_SEQ 77..84
FT /note="SPSSNSST -> MWSGLPSR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015976"
FT VAR_SEQ 366..368
FT /note="HIS -> PKA (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_015977"
FT VAR_SEQ 369..471
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_015978"
FT VAR_SEQ 386..406
FT /note="SPYNKLQRSPSILAAKLAFQK -> TPCKVIGLLPKPLPPANRQLS (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015979"
FT VAR_SEQ 407..471
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015980"
FT VARIANT 242
FT /note="S -> G (in dbSNP:rs2271761)"
FT /id="VAR_053765"
FT VARIANT 416
FT /note="F -> Y"
FT /evidence="ECO:0000269|PubMed:26755636"
FT /id="VAR_076447"
FT CONFLICT 254
FT /note="L -> P (in Ref. 1; BAB71629)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="A -> S (in Ref. 1; BAC04870)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 471 AA; 50407 MW; 052813B99B908515 CRC64;
MNMANFLRGF EEKGIKNDRP EDQLSKEKKK ILFSFCEVCN IQLNSAAQAQ VHSNGKSHRK
RVKQLSDGQP PPPAQASPSS NSSTGSTCHT TTLPALVRTP TLMMQPSLDI KPFMSFPVDS
SSAVGLFPNF NTMDPVQKAV INHTFGVSIP PKKKQVISCN VCQLRFNSDS QAEAHYKGSK
HAKKVKALDA TKNKPKMVPS KDSAKANPSC SITPITGNNS DKSEDKGKLK ASSSSQPSSS
ESGSFLLKSG TTPLPPGAAT SPSKSTNGAP GTVVESEEEK AKKLLYCSLC KVAVNSLSQL
EAHNTGSKHK TMVEARNGAG PIKSYPRPGS RLKMQNGSKG SGLQNKTFHC EICDVHVNSE
IQLKQHISSR RHKDRVAGKP LKPKYSPYNK LQRSPSILAA KLAFQKDMMK PLAPAFLSSP
LAAAAAVSSA LSLPPRPSAS LFQAPAIPPA LLRPGHGPIR ATPASILFAP Y
