Z385B_MOUSE
ID Z385B_MOUSE Reviewed; 482 AA.
AC Q8BXJ8; Q8BWQ7;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc finger protein 385B;
DE AltName: Full=Zinc finger protein 533;
GN Name=Znf385b; Synonyms=Zfp385b, Zfp533, Znf533;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Liver, Medulla oblongata, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=26755636; DOI=10.1101/gr.199430.115;
RA Spielmann M., Kakar N., Tayebi N., Leettola C., Nuernberg G., Sowada N.,
RA Lupianez D.G., Harabula I., Floettmann R., Horn D., Chan W.L., Wittler L.,
RA Yilmaz R., Altmueller J., Thiele H., van Bokhoven H., Schwartz C.E.,
RA Nuernberg P., Bowie J.U., Ahmad J., Kubisch C., Mundlos S., Borck G.;
RT "Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK
RT as a cause of limb defects in humans and mice.";
RL Genome Res. 26:183-191(2016).
CC -!- FUNCTION: May play a role in p53/TP53-mediated apoptosis.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with p53/TP53; the interaction is direct.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BXJ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BXJ8-2; Sequence=VSP_015981;
CC -!- DEVELOPMENTAL STAGE: Mainly expressed in developing brain.
CC {ECO:0000269|PubMed:26755636}.
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DR EMBL; AK046798; BAC32874.1; -; mRNA.
DR EMBL; AK050293; BAC34170.1; -; mRNA.
DR EMBL; AK149352; BAE28828.1; -; mRNA.
DR CCDS; CCDS16164.1; -. [Q8BXJ8-1]
DR CCDS; CCDS50611.1; -. [Q8BXJ8-2]
DR RefSeq; NP_001106870.1; NM_001113399.1.
DR RefSeq; NP_001106871.1; NM_001113400.1. [Q8BXJ8-2]
DR RefSeq; NP_848838.2; NM_178723.6. [Q8BXJ8-1]
DR AlphaFoldDB; Q8BXJ8; -.
DR BioGRID; 232317; 1.
DR IntAct; Q8BXJ8; 1.
DR MINT; Q8BXJ8; -.
DR STRING; 10090.ENSMUSP00000107461; -.
DR iPTMnet; Q8BXJ8; -.
DR PhosphoSitePlus; Q8BXJ8; -.
DR MaxQB; Q8BXJ8; -.
DR PaxDb; Q8BXJ8; -.
DR PRIDE; Q8BXJ8; -.
DR ProteomicsDB; 298486; -. [Q8BXJ8-2]
DR Antibodypedia; 33976; 233 antibodies from 16 providers.
DR DNASU; 241494; -.
DR Ensembl; ENSMUST00000090766; ENSMUSP00000088271; ENSMUSG00000027016. [Q8BXJ8-1]
DR Ensembl; ENSMUST00000111830; ENSMUSP00000107461; ENSMUSG00000027016. [Q8BXJ8-2]
DR Ensembl; ENSMUST00000111831; ENSMUSP00000107462; ENSMUSG00000027016. [Q8BXJ8-1]
DR GeneID; 241494; -.
DR KEGG; mmu:241494; -.
DR UCSC; uc008kfy.3; mouse. [Q8BXJ8-1]
DR CTD; 241494; -.
DR MGI; MGI:2444734; Zfp385b.
DR VEuPathDB; HostDB:ENSMUSG00000027016; -.
DR eggNOG; ENOG502QS7G; Eukaryota.
DR GeneTree; ENSGT00940000155611; -.
DR HOGENOM; CLU_027876_1_0_1; -.
DR InParanoid; Q8BXJ8; -.
DR OMA; GSRMKVQ; -.
DR OrthoDB; 899600at2759; -.
DR PhylomeDB; Q8BXJ8; -.
DR TreeFam; TF326622; -.
DR BioGRID-ORCS; 241494; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Zfp385b; mouse.
DR PRO; PR:Q8BXJ8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BXJ8; protein.
DR Bgee; ENSMUSG00000027016; Expressed in pigmented layer of retina and 173 other tissues.
DR ExpressionAtlas; Q8BXJ8; baseline and differential.
DR Genevisible; Q8BXJ8; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0002039; F:p53 binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; ISS:UniProtKB.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 4.
DR SUPFAM; SSF57667; SSF57667; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..482
FT /note="Zinc finger protein 385B"
FT /id="PRO_0000191813"
FT ZN_FING 34..64
FT /note="Matrin-type 1"
FT ZN_FING 169..199
FT /note="Matrin-type 2"
FT ZN_FING 294..328
FT /note="Matrin-type 3"
FT ZN_FING 360..390
FT /note="Matrin-type 4"
FT REGION 1..105
FT /note="Required for induction of apoptosis"
FT /evidence="ECO:0000250"
FT REGION 54..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..482
FT /note="Interaction with p53/TP53"
FT /evidence="ECO:0000250"
FT REGION 189..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_015981"
SQ SEQUENCE 482 AA; 51356 MW; C9F234F5E18E1B71 CRC64;
MNMATFLRGF EEKGLKNDRP GDQFSKEKKK ILFSFCEVCN IQLNSAAQAQ VHYDGKSHRK
RVKQLSDGQP PPPVQGSVPL LAGPCPCPGP GPNTSTGSAC HTTTLPALVR TPTLMMQPSL
DIKPFMSFPV DSSSAVGLFP NFNTMDPVQK AVINHTFGVS IPPKKKQVIS CNVCQLRFNS
DSQAEAHYKG SKHAKKVKAL EATKNKPKMV PSKDSAKANP SCSIRPGTGD SSDKSEDKGK
IKATSSSQPS GSEGGSFLLK SGTTPLPLGA IASPSKSTNG APGSVAESEE EKAKKLLYCS
LCKVAVNSLS QLEAHNTGSK HKTMVEARNG AGPIKSYPRP GSRLKVQNGS KGSGLQNKMF
HCEICDVHVN SEIQLKQHIS SRRHKDRVAG KPLKPKYSPY NKLQRSPSIL AAKLAFQKDL
MKPLAPTFLS SPLAAAAVSS ALSLPPRPSA SLFQAAAIPP ALLRPGHGPI RATPASILFA
PY
