Z385C_HUMAN
ID Z385C_HUMAN Reviewed; 422 AA.
AC Q66K41; A0A087WX54; Q4G0J1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-JUN-2020, sequence version 4.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc finger protein 385C {ECO:0000312|HGNC:HGNC:33722};
GN Name=ZNF385C {ECO:0000312|HGNC:HGNC:33722};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q66K41; Q8N9W6: BOLL; NbExp=4; IntAct=EBI-8651919, EBI-998198;
CC Q66K41; P61978: HNRNPK; NbExp=7; IntAct=EBI-8651919, EBI-304185;
CC Q66K41; P25788: PSMA3; NbExp=4; IntAct=EBI-8651919, EBI-348380;
CC Q66K41; Q15415: RBMY1J; NbExp=3; IntAct=EBI-8651919, EBI-8642021;
CC Q66K41; Q93062: RBPMS; NbExp=3; IntAct=EBI-8651919, EBI-740322;
CC Q66K41; Q9NVV9: THAP1; NbExp=4; IntAct=EBI-8651919, EBI-741515;
CC Q66K41-2; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-12055653, EBI-11983447;
CC Q66K41-2; P86480: PRR20D; NbExp=3; IntAct=EBI-12055653, EBI-12754095;
CC Q66K41-2; A0AV96: RBM47; NbExp=3; IntAct=EBI-12055653, EBI-2823850;
CC Q66K41-2; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-12055653, EBI-11987469;
CC Q66K41-2; Q05519-2: SRSF11; NbExp=3; IntAct=EBI-12055653, EBI-11975029;
CC Q66K41-2; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-12055653, EBI-741515;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q66K41-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q66K41-2; Sequence=VSP_031546;
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DR EMBL; AC105024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC080613; AAH80613.1; -; mRNA.
DR AlphaFoldDB; Q66K41; -.
DR IntAct; Q66K41; 12.
DR MINT; Q66K41; -.
DR STRING; 9606.ENSP00000480744; -.
DR iPTMnet; Q66K41; -.
DR PhosphoSitePlus; Q66K41; -.
DR BioMuta; ZNF385C; -.
DR DMDM; 172044654; -.
DR PaxDb; Q66K41; -.
DR PeptideAtlas; Q66K41; -.
DR PRIDE; Q66K41; -.
DR Antibodypedia; 29099; 35 antibodies from 7 providers.
DR Ensembl; ENST00000618554.4; ENSP00000480744.1; ENSG00000187595.17.
DR GeneCards; ZNF385C; -.
DR HGNC; HGNC:33722; ZNF385C.
DR HPA; ENSG00000187595; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q66K41; -.
DR VEuPathDB; HostDB:ENSG00000187595; -.
DR eggNOG; ENOG502QTBM; Eukaryota.
DR InParanoid; Q66K41; -.
DR OrthoDB; 899600at2759; -.
DR PhylomeDB; Q66K41; -.
DR PathwayCommons; Q66K41; -.
DR SignaLink; Q66K41; -.
DR BioGRID-ORCS; 201181; 4 hits in 185 CRISPR screens.
DR ChiTaRS; ZNF385C; human.
DR GenomeRNAi; 201181; -.
DR Pharos; Q66K41; Tdark.
DR PRO; PR:Q66K41; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q66K41; protein.
DR Bgee; ENSG00000187595; Expressed in cartilage tissue and 103 other tissues.
DR ExpressionAtlas; Q66K41; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR SUPFAM; SSF57667; SSF57667; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..422
FT /note="Zinc finger protein 385C"
FT /id="PRO_0000319941"
FT ZN_FING 77..107
FT /note="Matrin-type 1"
FT ZN_FING 225..259
FT /note="Matrin-type 2"
FT ZN_FING 290..320
FT /note="Matrin-type 3"
FT REGION 107..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..248
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031546"
SQ SEQUENCE 422 AA; 44149 MW; 716E7C8FFA0F6219 CRC64;
MLLGPASGAP SPLLASLPLP TRPLQPPLDF KHLLAFHFNG AAPLSLFPNF STMDPVQKAV
ISHTFGVPSP LKKKLFISCN ICHLRFNSAN QAEAHYKGHK HARKLKAVEA AKSKQRPHTQ
AQDGAVVSPI PTLASGAPGE PQSKVPAAPP LGPPLQPPPT PDPTCREPAH SELLDAASSS
SSSSCPPCSP EPGREAPGPE PAAAAVGSSM SGEGRSEKGH LYCPTCKVTV NSASQLQAHN
TGAKHRWMME GQRGAPRRSR GRPVSRGGAG HKAKRVTGGR GGRQGPSPAF HCALCQLQVN
SETQLKQHMS SRRHKDRLAG KTPKPSSQHS KLQKHAALAV SILKSKLALQ KQLTKTLAAR
FLPSPLPTAA TAICALPGPL ALRPAPTAAT TLFPAPILGP ALFRTPAGAV RPATGPIVLA
PY
