Z385C_MOUSE
ID Z385C_MOUSE Reviewed; 429 AA.
AC A2A5E6; Q14AS5; Q8C8X1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Zinc finger protein 385C {ECO:0000305};
GN Name=Znf385c {ECO:0000250|UniProtKB:Q66K41};
GN Synonyms=Zfp385c {ECO:0000312|MGI:MGI:3608347};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2A5E6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2A5E6-2; Sequence=VSP_031547;
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DR EMBL; AK044299; BAC31860.1; -; mRNA.
DR EMBL; AL591469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116726; AAI16727.1; -; mRNA.
DR CCDS; CCDS25430.1; -. [A2A5E6-1]
DR RefSeq; NP_808458.2; NM_177790.4. [A2A5E6-1]
DR RefSeq; XP_006533557.1; XM_006533494.3.
DR AlphaFoldDB; A2A5E6; -.
DR STRING; 10090.ENSMUSP00000099408; -.
DR PhosphoSitePlus; A2A5E6; -.
DR PaxDb; A2A5E6; -.
DR PRIDE; A2A5E6; -.
DR ProteomicsDB; 302098; -. [A2A5E6-1]
DR ProteomicsDB; 302099; -. [A2A5E6-2]
DR Antibodypedia; 29099; 35 antibodies from 7 providers.
DR DNASU; 278304; -.
DR Ensembl; ENSMUST00000103119; ENSMUSP00000099408; ENSMUSG00000014198. [A2A5E6-1]
DR GeneID; 278304; -.
DR KEGG; mmu:278304; -.
DR UCSC; uc007llv.2; mouse. [A2A5E6-1]
DR UCSC; uc011yfc.1; mouse. [A2A5E6-2]
DR CTD; 278304; -.
DR MGI; MGI:3608347; Zfp385c.
DR VEuPathDB; HostDB:ENSMUSG00000014198; -.
DR eggNOG; ENOG502QTBM; Eukaryota.
DR GeneTree; ENSGT00940000157202; -.
DR HOGENOM; CLU_027876_0_0_1; -.
DR InParanoid; A2A5E6; -.
DR OMA; CTMPGPL; -.
DR OrthoDB; 899600at2759; -.
DR PhylomeDB; A2A5E6; -.
DR TreeFam; TF326622; -.
DR BioGRID-ORCS; 278304; 8 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp385c; mouse.
DR PRO; PR:A2A5E6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2A5E6; protein.
DR Bgee; ENSMUSG00000014198; Expressed in extra-ocular muscle and 48 other tissues.
DR ExpressionAtlas; A2A5E6; baseline and differential.
DR Genevisible; A2A5E6; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR SUPFAM; SSF57667; SSF57667; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..429
FT /note="Zinc finger protein 385C"
FT /id="PRO_0000319942"
FT ZN_FING 77..107
FT /note="Matrin-type 1"
FT ZN_FING 225..259
FT /note="Matrin-type 2"
FT ZN_FING 297..327
FT /note="Matrin-type 3"
FT REGION 109..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 3
FT /note="L -> LA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031547"
FT CONFLICT 269
FT /note="R -> C (in Ref. 1; BAC31860 and 3; AAI16727)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="N -> S (in Ref. 1; BAC31860 and 3; AAI16727)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 429 AA; 44644 MW; 64E6DF5CB2F27824 CRC64;
MLLGPASGSP SPLLASLTLP ARPLQPPLDL KHLLAFHLNG TTPLSLFPNF STMDPVQKAV
ISHTFGVPSP LKKKLFISCN ICHLRFNSAN QAEAHYKGHR HARKLKAVEA AKSKQRPRNP
TTNGTVVSSA SPPASGSPGT PQSKGPASPP LGPSLQLPPT PDPSAGDPVH SAGDPVHSEL
CDAAASSSSS SCPPCSPDPS REAPGPEPAE GAVGSGVNGE GRGEKGRLYC PTCKVTVNSA
SQLQAHNTGA KHRWMVEGHQ GAPRRGRGRP VSRGGTGHKT KRVIGNRGGR QGPSPPFHCA
LCQLHVNSET QLKQHMSSRR HKDRLAGKPP KSSSQHNKLQ KHTALAVSVL KSKLALQKQL
TKTLAARFLP GPLPTTAAAI CALPGPLTLR PAATAAATLF PAPVLGPALF RSPAGAVRPA
AGPILFAPY
