Z385D_HUMAN
ID Z385D_HUMAN Reviewed; 395 AA.
AC Q9H6B1;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger protein 385D;
DE AltName: Full=Zinc finger protein 659;
GN Name=ZNF385D; Synonyms=ZNF659;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney epithelium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANTS [LARGE SCALE ANALYSIS] THR-386 AND GLN-387.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AK026072; BAB15350.1; -; mRNA.
DR EMBL; BC007212; AAH07212.1; -; mRNA.
DR CCDS; CCDS2636.1; -.
DR RefSeq; NP_078973.1; NM_024697.2.
DR AlphaFoldDB; Q9H6B1; -.
DR BioGRID; 122861; 1.
DR IntAct; Q9H6B1; 1.
DR STRING; 9606.ENSP00000281523; -.
DR GlyGen; Q9H6B1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H6B1; -.
DR PhosphoSitePlus; Q9H6B1; -.
DR BioMuta; ZNF385D; -.
DR DMDM; 74733598; -.
DR EPD; Q9H6B1; -.
DR MassIVE; Q9H6B1; -.
DR PaxDb; Q9H6B1; -.
DR PeptideAtlas; Q9H6B1; -.
DR PRIDE; Q9H6B1; -.
DR ProteomicsDB; 80972; -.
DR Antibodypedia; 27129; 81 antibodies from 21 providers.
DR DNASU; 79750; -.
DR Ensembl; ENST00000281523.8; ENSP00000281523.2; ENSG00000151789.12.
DR GeneID; 79750; -.
DR KEGG; hsa:79750; -.
DR MANE-Select; ENST00000281523.8; ENSP00000281523.2; NM_024697.3; NP_078973.1.
DR UCSC; uc003cce.4; human.
DR CTD; 79750; -.
DR DisGeNET; 79750; -.
DR GeneCards; ZNF385D; -.
DR HGNC; HGNC:26191; ZNF385D.
DR HPA; ENSG00000151789; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q9H6B1; -.
DR OpenTargets; ENSG00000151789; -.
DR PharmGKB; PA162410152; -.
DR VEuPathDB; HostDB:ENSG00000151789; -.
DR eggNOG; ENOG502QY40; Eukaryota.
DR GeneTree; ENSGT00940000160242; -.
DR HOGENOM; CLU_027876_1_0_1; -.
DR InParanoid; Q9H6B1; -.
DR OMA; RNIMYFX; -.
DR OrthoDB; 899600at2759; -.
DR PhylomeDB; Q9H6B1; -.
DR TreeFam; TF326622; -.
DR PathwayCommons; Q9H6B1; -.
DR SignaLink; Q9H6B1; -.
DR BioGRID-ORCS; 79750; 8 hits in 1072 CRISPR screens.
DR ChiTaRS; ZNF385D; human.
DR GenomeRNAi; 79750; -.
DR Pharos; Q9H6B1; Tdark.
DR PRO; PR:Q9H6B1; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9H6B1; protein.
DR Bgee; ENSG00000151789; Expressed in descending thoracic aorta and 142 other tissues.
DR ExpressionAtlas; Q9H6B1; baseline and differential.
DR Genevisible; Q9H6B1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR SUPFAM; SSF57667; SSF57667; 3.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..395
FT /note="Zinc finger protein 385D"
FT /id="PRO_0000191819"
FT ZN_FING 80..110
FT /note="Matrin-type 1"
FT ZN_FING 204..234
FT /note="Matrin-type 2"
FT ZN_FING 267..297
FT /note="Matrin-type 3"
FT REGION 169..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 386
FT /note="A -> T (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs757067821)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036058"
FT VARIANT 387
FT /note="H -> Q (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036059"
SQ SEQUENCE 395 AA; 42296 MW; D16D251A935776AA CRC64;
MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF PNFNAMDPIQ
KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK GTKHAKKLKA LEAMKNKQKS
VTAKDSAKTT FTSITTNTIN TSSDKTDGTA GTPAISTTTT VEIRKSSVMT TEITSKVEKS
PTTATGNSSC PSTETEEEKA KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT
IKAFPRAGVK GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP
KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA VSSPFSLRTA
PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY
