CC124_MOUSE
ID CC124_MOUSE Reviewed; 217 AA.
AC Q9D8X2; Q8C2T0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Coiled-coil domain-containing protein 124;
GN Name=Ccdc124;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Pancreas, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for proper progression of late cytokinetic stages.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RASGEF1B. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Midbody {ECO:0000250}.
CC Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase,
CC and anaphase. Relocates from centrosome to midbody at telophase (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCDC124 family. {ECO:0000305}.
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DR EMBL; AK007589; BAB25123.1; -; mRNA.
DR EMBL; AK088037; BAC40110.1; -; mRNA.
DR EMBL; BC049678; AAH49678.1; -; mRNA.
DR EMBL; BC050938; AAH50938.1; -; mRNA.
DR CCDS; CCDS22384.1; -.
DR RefSeq; NP_081240.1; NM_026964.3.
DR RefSeq; XP_006509718.1; XM_006509655.3.
DR AlphaFoldDB; Q9D8X2; -.
DR SMR; Q9D8X2; -.
DR BioGRID; 231525; 3.
DR IntAct; Q9D8X2; 2.
DR MINT; Q9D8X2; -.
DR STRING; 10090.ENSMUSP00000007865; -.
DR iPTMnet; Q9D8X2; -.
DR PhosphoSitePlus; Q9D8X2; -.
DR EPD; Q9D8X2; -.
DR jPOST; Q9D8X2; -.
DR MaxQB; Q9D8X2; -.
DR PaxDb; Q9D8X2; -.
DR PeptideAtlas; Q9D8X2; -.
DR PRIDE; Q9D8X2; -.
DR ProteomicsDB; 265284; -.
DR Antibodypedia; 27882; 86 antibodies from 16 providers.
DR DNASU; 234388; -.
DR Ensembl; ENSMUST00000007865; ENSMUSP00000007865; ENSMUSG00000007721.
DR GeneID; 234388; -.
DR KEGG; mmu:234388; -.
DR UCSC; uc009mby.1; mouse.
DR CTD; 115098; -.
DR MGI; MGI:1916403; Ccdc124.
DR VEuPathDB; HostDB:ENSMUSG00000007721; -.
DR eggNOG; KOG3223; Eukaryota.
DR GeneTree; ENSGT00390000012482; -.
DR HOGENOM; CLU_069723_0_1_1; -.
DR InParanoid; Q9D8X2; -.
DR OMA; RHPEKRM; -.
DR OrthoDB; 1585903at2759; -.
DR PhylomeDB; Q9D8X2; -.
DR TreeFam; TF105913; -.
DR BioGRID-ORCS; 234388; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc124; mouse.
DR PRO; PR:Q9D8X2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D8X2; protein.
DR Bgee; ENSMUSG00000007721; Expressed in ear vesicle and 228 other tissues.
DR ExpressionAtlas; Q9D8X2; baseline and differential.
DR Genevisible; Q9D8X2; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR010422; Ccdc124/Oxs1.
DR PANTHER; PTHR21680; PTHR21680; 1.
DR Pfam; PF06244; Ccdc124; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..217
FT /note="Coiled-coil domain-containing protein 124"
FT /id="PRO_0000263736"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..82
FT /evidence="ECO:0000255"
FT COMPBIAS 14..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96CT7"
FT MOD_RES 188
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96CT7"
FT CONFLICT 23
FT /note="K -> Q (in Ref. 1; BAC40110)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="K -> E (in Ref. 1; BAC40110)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 25346 MW; 3050D1DFD815E769 CRC64;
MPKKFQGENS KSAAARARRA EAKAAADAKK QKELEDAYWK DEDKHVMRKE QRKEEKEKRR
LEQLERKKET QRLLEEEDSR LKGGKAPRVA PAKVTRAQIE DSLRREQRAE PVEKAKSHLE
LPLEENLNRR LQEEGSVEAR TVEDAIAVLS VAEEADRHPE RRMRAAFTAF EEVQLPRLKQ
ENPNMRLSQL KQLLKKEWLR SPDNPMNQRA LPFNAPK
