Z3H7A_HUMAN
ID Z3H7A_HUMAN Reviewed; 971 AA.
AC Q8IWR0; D3DUG5; Q9NPE9;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Zinc finger CCCH domain-containing protein 7A;
GN Name=ZC3H7A; Synonyms=ZC3H7, ZC3HDC7; ORFNames=HSPC055;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RA Chen L., Guo J.H.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Skeletal muscle, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [11]
RP FUNCTION, AND MIRNA-BINDING.
RX PubMed=28431233; DOI=10.1016/j.molcel.2017.03.014;
RA Treiber T., Treiber N., Plessmann U., Harlander S., Daiss J.L., Eichner N.,
RA Lehmann G., Schall K., Urlaub H., Meister G.;
RT "A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.";
RL Mol. Cell 66:270-284(2017).
RN [12]
RP STRUCTURE BY NMR OF 892-947.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of CCCH type zinc-finger domain 3 in zinc finger CCCH-
RT type domain containing 7a.";
RL Submitted (JUN-2006) to the PDB data bank.
CC -!- FUNCTION: May be a specific regulator of miRNA biogenesis. Binds to
CC microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-
CC ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.
CC -!- INTERACTION:
CC Q8IWR0-2; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-12242934, EBI-10288852;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IWR0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IWR0-2; Sequence=VSP_014383;
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DR EMBL; AY163807; AAO06906.1; -; mRNA.
DR EMBL; AF161540; AAF29027.1; -; mRNA.
DR EMBL; AK000889; BAA91408.1; -; mRNA.
DR EMBL; AK001869; BAA91952.1; -; mRNA.
DR EMBL; CH471112; EAW85138.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85139.1; -; Genomic_DNA.
DR EMBL; BC012575; AAH12575.1; -; mRNA.
DR EMBL; BC046363; AAH46363.1; -; mRNA.
DR CCDS; CCDS10550.1; -. [Q8IWR0-1]
DR RefSeq; NP_054872.2; NM_014153.3. [Q8IWR0-1]
DR RefSeq; XP_006720940.1; XM_006720877.2. [Q8IWR0-1]
DR RefSeq; XP_011520765.1; XM_011522463.1. [Q8IWR0-1]
DR PDB; 2D9M; NMR; -; A=892-947.
DR PDBsum; 2D9M; -.
DR AlphaFoldDB; Q8IWR0; -.
DR SMR; Q8IWR0; -.
DR BioGRID; 118841; 212.
DR IntAct; Q8IWR0; 12.
DR MINT; Q8IWR0; -.
DR STRING; 9606.ENSP00000379773; -.
DR iPTMnet; Q8IWR0; -.
DR PhosphoSitePlus; Q8IWR0; -.
DR BioMuta; ZC3H7A; -.
DR DMDM; 68566208; -.
DR EPD; Q8IWR0; -.
DR jPOST; Q8IWR0; -.
DR MassIVE; Q8IWR0; -.
DR MaxQB; Q8IWR0; -.
DR PaxDb; Q8IWR0; -.
DR PeptideAtlas; Q8IWR0; -.
DR PRIDE; Q8IWR0; -.
DR ProteomicsDB; 70882; -. [Q8IWR0-1]
DR ProteomicsDB; 70883; -. [Q8IWR0-2]
DR Antibodypedia; 24731; 136 antibodies from 22 providers.
DR DNASU; 29066; -.
DR Ensembl; ENST00000355758.9; ENSP00000347999.4; ENSG00000122299.12. [Q8IWR0-1]
DR Ensembl; ENST00000396516.6; ENSP00000379773.2; ENSG00000122299.12. [Q8IWR0-1]
DR Ensembl; ENST00000575984.1; ENSP00000459477.1; ENSG00000122299.12. [Q8IWR0-2]
DR GeneID; 29066; -.
DR KEGG; hsa:29066; -.
DR MANE-Select; ENST00000355758.9; ENSP00000347999.4; NM_014153.4; NP_054872.2.
DR UCSC; uc002dbl.4; human. [Q8IWR0-1]
DR CTD; 29066; -.
DR DisGeNET; 29066; -.
DR GeneCards; ZC3H7A; -.
DR HGNC; HGNC:30959; ZC3H7A.
DR HPA; ENSG00000122299; Low tissue specificity.
DR MIM; 619819; gene.
DR neXtProt; NX_Q8IWR0; -.
DR OpenTargets; ENSG00000122299; -.
DR PharmGKB; PA128394652; -.
DR VEuPathDB; HostDB:ENSG00000122299; -.
DR eggNOG; ENOG502QSHP; Eukaryota.
DR GeneTree; ENSGT00390000018542; -.
DR HOGENOM; CLU_135703_0_0_1; -.
DR InParanoid; Q8IWR0; -.
DR OMA; ESKQYWQ; -.
DR OrthoDB; 369231at2759; -.
DR PhylomeDB; Q8IWR0; -.
DR TreeFam; TF329017; -.
DR PathwayCommons; Q8IWR0; -.
DR SignaLink; Q8IWR0; -.
DR BioGRID-ORCS; 29066; 24 hits in 1092 CRISPR screens.
DR ChiTaRS; ZC3H7A; human.
DR EvolutionaryTrace; Q8IWR0; -.
DR GenomeRNAi; 29066; -.
DR Pharos; Q8IWR0; Tbio.
DR PRO; PR:Q8IWR0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8IWR0; protein.
DR Bgee; ENSG00000122299; Expressed in calcaneal tendon and 198 other tissues.
DR ExpressionAtlas; Q8IWR0; baseline and differential.
DR Genevisible; Q8IWR0; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035198; F:miRNA binding; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0035196; P:miRNA processing; IMP:UniProtKB.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IMP:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR039691; ZC3H7A/B.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR14928; PTHR14928; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR SUPFAM; SSF90229; SSF90229; 2.
DR PROSITE; PS50103; ZF_C3H1; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; RNA-binding; TPR repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..971
FT /note="Zinc finger CCCH domain-containing protein 7A"
FT /id="PRO_0000106321"
FT REPEAT 43..76
FT /note="TPR 1"
FT REPEAT 89..122
FT /note="TPR 2"
FT REPEAT 124..156
FT /note="TPR 3"
FT ZN_FING 634..656
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 769..797
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 857..881
FT /note="C2H2-type"
FT ZN_FING 906..928
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT COILED 924..952
FT /evidence="ECO:0000255"
FT MOD_RES 210
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT VAR_SEQ 1..804
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11042152,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_014383"
FT VARIANT 3
FT /note="N -> S (in dbSNP:rs1429077)"
FT /id="VAR_052632"
FT VARIANT 57
FT /note="H -> R (in dbSNP:rs16958654)"
FT /id="VAR_052633"
FT HELIX 908..912
FT /evidence="ECO:0007829|PDB:2D9M"
FT STRAND 922..926
FT /evidence="ECO:0007829|PDB:2D9M"
FT HELIX 927..940
FT /evidence="ECO:0007829|PDB:2D9M"
FT TURN 941..943
FT /evidence="ECO:0007829|PDB:2D9M"
SQ SEQUENCE 971 AA; 110538 MW; A62D4EF6BC639181 CRC64;
MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG NDVYREHDWN
NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS NMGFHDKVLE DCNIVLSLNA
SNCKALYRKS KALSDLGRYK KAYDAVAKCS LAVPQDEHVI KLTQELAQKL GFKIRKAYVR
AELSLKSVPG DGATKALNHS VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM
PLTSILPLQV EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV
MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS SLEDFCSSLN
SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA SENFLGISSQ PRNDFGNFFG
SAVTKPSSSV TPRHPLEGTH ELRQACQICF VKSGPKLMDF TYHANIDHKC KKDILIGRIK
NVEDKSWKKI RPRPTKTNYE GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA
FSREAFFGGN GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK
HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF YAHSLVELKV
WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM PGFLNMKIKF VCAQCLRNGQ
VIEPDKNRKY CSAKARHSWT KDRRAMRVMS IERKKWMNIR PLPTKKQMPL QFDLCNHIAS
GKKCQYVGNC SFAHSPEERE VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN
GKQIHMPTDY AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP
TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD HLIGPNDNDF
GKYSFLFKDL N
